Results 71 to 80 of about 1,517 (162)
PLoS Pathogens, 2017 Many pathogens, including Kaposi's sarcoma herpesvirus (KSHV), lack tractable small animal models. KSHV persists as a multi-copy, nuclear episome in latently infected cells. KSHV latency-associated nuclear antigen (kLANA) binds viral terminal repeat (kTR)
Aline C Habison +10 more
doaj +1 more source
Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. [PDF]
PLoS ONE, 2013 The mechanisms underlying latent-virus-mediated heterologous immunity, and subsequent transplant rejection, especially in the setting of T cell costimulation blockade, remain undetermined. To address this, we have utilized MHV68 to develop a rodent model
Jonathan M Beus +11 more
doaj +1 more source
cGAS–STING, an important signaling pathway in diseases and their therapy
MedComm, Volume 5, Issue 4, April 2024.cGAS–STING signaling pathway was discovered in 2013. With so many years of in‐depth research on cGAS–STING, people have realized that cGAS–STING plays a key role in human diseases, particularly DNA‐triggered inflammatory diseases and cancers. This review summarize the ancient origin, triggers, transduction, and regulating mechanisms of the cGAS–STING ...
Qijie Li +5 more
wiley +1 more source
MHV68 infection upregulates expression of HIF1 alpha.
, 2019 (A) 3T12 fibroblasts were infected with a wild type strain of MHV68 (WUMS) (5 MOI) at 21% O2 (cell culture incubator) and protein lysates were analyzed by western blot for the expression of HIF1α protein at different time-points.
Darlah M. López-Rodríguez (8098544) +4 more
core +1 more source
mSphere, 2016 Recent intense investigations have uncovered important functions for a diverse array of novel noncoding RNA (ncRNA) species, including microRNAs (miRNAs) and long noncoding RNAs.
Emily R. Feldman +9 more
doaj +1 more source
MHV68.vBcl2stop is attenuated in B cells undergoing negative selection.
, 2014 B6 mice were infected i.n. with 104 PFU wild-type MHV68 or MHV68.vBcl-2stop. Sixteen days post-inoculation bone marrow and spleens were harvested from five mice per sample group in each experiment.
Jennifer E. McGraw (584494) +10 more
core +1 more source
MHV68 infection induces SINE RNA expression with rapid kinetics.
, 2015 (A) NIH3T3 cells were infected with MHV68 at an MOI of 5, and 24 hpi total RNA was primer extended for B1, B2, and 7SK RNAs. (B) The RNA described in (A) was used to monitor the levels of tRNAVal, tRNALeu, 5S rRNA, and 7SL RNA by small RNA northern ...
Emma Abernathy (392118) +2 more
core +1 more source
Targets of MHV68 miRNAs are repressed in vivo.
, 2019 The relative expression of endogenous mRNAs in non-infected versus infected B cells sorted from in vivo samples during chronic infection. Wild-type B6 mice were infected i.n. with 104 PFU of MHV68-H2bYFP.
Yiping Wang (1484218) +10 more
core +1 more source
MHV68 causes systemic elevation of the chemoattractant chemokines CXCL9 and CXCL10.
, 2013 A) Quantification of CXCL9 in the plasma of MHV68-infected animals measured every 2 weeks for 10 weeks after infection. B) Quantification of CXCL10 in the plasma of MHV68-infected animals measured every 2 weeks for 10 weeks after infection.
Danxia Duan (441626) +11 more
core +1 more source
Latent infection with MHV68 results in abbreviated skin allograft survival.
, 2013 A) Kaplan-Meier survival curves showing skin graft survival for the following cohorts: Black solid line - Non-infected B6 recipients of BALB/C skin allografts, receiving CTLA-4-Ig+anti-CD154 CoB. N = 48, 8 independent experiments, MST 22 d.
Danxia Duan (441626) +11 more
core +1 more source