Results 51 to 60 of about 1,517 (162)
Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection. [PDF]
PLoS ONE, 2012 Herpesviruses are characterized by their ability to establish lifelong latent infection. The gammaherpesvirus subfamily is distinguished by lymphotropism, establishing and maintaining latent infection predominantly in B lymphocytes.
Kathleen S Gray +2 more
doaj +1 more source
Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help.
PLoS Pathogens, 2014 X linked lymphoproliferative disease (XLP) is an inherited immunodeficiency resulting from mutations in the gene encoding the slam associated protein (SAP).
Christopher M Collins, Samuel H Speck
doaj +1 more source
PLoS ONE, 2021 Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) are cancer-causing viruses that establish lifelong infections in humans. Gene editing using the Cas9-guideRNA (gRNA) CRISPR system has been applied to decrease the latent load of EBV in human
Hui-Chen Chang Foreman +7 more
doaj +1 more source
, 2013 A) An expression cassette that expresses a histone H2bYFP fusion protein was cloned into the intergenic region between ORFs 27 and 29b. The cassette was flanked by chromatin insulators (XL9CD) as previously described [4] B). Representative plaques formed
Samuel H. Speck (70359) +1 more
core +1 more source
Phosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replication. [PDF]
PLoS Pathogens, 2013 Lytic gammaherpesvirus (GHV) replication facilitates the establishment of lifelong latent infection, which places the infected host at risk for numerous cancers. As obligate intracellular parasites, GHVs must control and usurp cellular signaling pathways
James A Stahl +6 more
doaj +1 more source
Neurobiology of Disease, 2022 Background: Motor symptoms of Parkinson's disease (PD) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated.
Amanda R. Burmeister +10 more
doaj +1 more source
Abbreviated skin allograft survival in MHV68 is not due to MHV68-associated Vβ4+CD8+ expansion.
, 2013 A) Representative flow cytometric plots showing TCR Vβ4 staining versus CD8 staining in mice infected with wild-type MHV68 (left) and the mutant M1.STOP MHV68 (right).
Danxia Duan (441626) +11 more
core +1 more source
PLoS ONE, 2015 Idiopathic pulmonary fibrosis (IPF), one of the most severe interstitial lung diseases, is a progressive fibrotic disorder of unknown etiology. However, there is growing appreciation for the role of viral infection in disease induction and/or progression.
Brigid M O'Flaherty +7 more
doaj +1 more source
A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality. [PDF]
PLoS Pathogens, 2011 The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals.
Pratyusha Mandal +6 more
doaj +1 more source
, 2013 Mice were infected with a 100 pfu of either MHV68-YFP or M2.Stop-YFP viruses via intranasal inoculation. (A) The absence of MHV68 infected plasma cells in mice infected with the M2.Stop-YFP virus.
Neal N. Iwakoshi (369025) +4 more
core +1 more source