Results 21 to 30 of about 1,517 (162)

Evaluation of immune sensor responses to a viral small noncoding RNA [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionGammaherpesviruses are widespread pathogens causing persistent infections linked to the development of numerous types of lymphomas in humans.
Mehmet Kara, Mehmet Kara, Scott A. Tibbetts   +2 more
doaj   +2 more sources

Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models [PDF]

mBio
Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription factor signal transducer and activator of transcription 3 (STAT3).
Chad H. Hogan, Shana M. Owens, Glennys V. Reynoso, Yifei Liao, Thomas J. Meyer, Monika A. Zelazowska, Bin Liu, Xiaofan Li, Anna K. Grosskopf, Camille Khairallah, Varvara Kirillov, Nancy C. Reich, Brian S. Sheridan, Kevin M. McBride, Benjamin E. Gewurz, Heather D. Hickman, J. Craig Forrest, Laurie T. Krug   +17 more
doaj   +2 more sources

Regulation of ribonucleoprotein condensates by RNase L during viral infection

WIREs RNA, Volume 14, Issue 4, July/August 2023., 2023
RNase L‐mediated mRNA decay inhibits stress granule assembly and promotes the assembly of RNase L‐dependent bodies. Abstract In response to viral infection, mammalian cells activate several innate immune pathways to antagonize viral gene expression. Upon recognition of viral double‐stranded RNA, protein kinase R (PKR) phosphorylates the alpha subunit ...
James M. Burke
wiley   +1 more source

Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen. [PDF]

PLoS Pathogens, 2011
Human gammaherpesviruses are associated with the development of lymphoproliferative diseases and B cell lymphomas, particularly in immunosuppressed hosts.
Xiaozhen Liang, Clinton R Paden, Francine M Morales, Ryan P Powers, Joshy Jacob, Samuel H Speck   +5 more
doaj   +1 more source

25‐hydroxycholesterol inhibits human papillomavirus infection in cervical epithelial cells by perturbing cytoskeletal remodeling

Journal of Medical Virology, Volume 95, Issue 6, June 2023., 2023
Abstract Persistent high‐risk human papilloma virus (HR‐HPV) infection is the main risk factor for cervical cancer, threatening women's health. Despite growing prophylactic vaccination, annual cervical cancer cases are still increasing and show a trend of younger onset age. However, therapeutic approaches towards HPV infection are still limited.
Boning Li, Chen Hua, Pu Tian, Yiou Sha, Lu Zhang, Qian Wang, Lu Lu, Shibo Jiang, Long Sui   +8 more
wiley   +1 more source

Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation.

PLoS Pathogens, 2020
Gammaherpesviruses have evolved various strategies to take advantage of host cellular factors or signaling pathways to establish a lifelong latent infection.
Shuai Liu, Zhangmengxue Lei, Jie Li, Liu Wang, Ran Jia, Zhongshun Liu, Congwei Jiang, Ying Gao, Mu Liu, Linlin Kuang, Zhikang Qian, Dongming Zhou, Samuel H Speck, Xiaozhen Liang   +13 more
doaj   +1 more source

Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases

Journal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
In recent years, there has been ample evidence illustrating the effect of microbiota on gut immunity, homeostasis, and disease. Most of these studies have engaged more efforts in understanding the role of the bacteriome in gut mucosal immunity and disease.
Njinju Asaba Clinton, Sodiq Ayobami Hameed, Eugene Kusi Agyei, Joy Chinwendu Jacob, Victor Oyewale Oyebanji, Cyril Ekabe Jabea, Payam Behzadi   +6 more
wiley   +1 more source

Increased MHV68 infection during HP coinfection requires GATA6-mediated LPM expansion during acute MHV68 infection.

, 2023
(A-E) Tamoxifen treated Gata6flox/flox and Gata6Δ Mac mice were infected with the MHV68.ORF73β-lactamase reporter virus, as in Fig 3. PECs were collected at day 2 of MHV68 infection for flow analysis. (A) Representative flow plots of macrophage gating at
Mihir Pendse (17181225), Phillip Dryden (17181228), Jaime Coronado (16770120), Lora V. Hooper (9645168), Chaitanya Dende (186970), Tiffany A. Reese (17181231), Christina M. Zarek (17181222)   +6 more
core   +1 more source

DESIGN AND GENERATION OF A RECOMBINANT GAMMAHERPESVIRUS ENCODING shRNA FROM A NATIVE VIRAL tRNA PROMOTER

Trakya University Journal of Natural Sciences, 2023
Gammaherpesviruses are associated with multiple types of tumor development and understanding the pathogenesis of these viruses has been the subject of various studies.
Scott Tibbetts, Mehmet Kara
doaj   +1 more source

Modified Cross‐Linking, Ligation, and Sequencing of Hybrids (qCLASH) to Identify MicroRNA Targets

Current Protocols, Volume 1, Issue 10, October 2021., 2021
Abstract This protocol was designed to identify microRNA (miRNA) targetomes from smaller‐input samples by performing a simplified workflow of the Cross‐Linking and Sequencing of Hybrids (CLASH) technique developed in the Tollervey group. In this ribonomics‐based technique, Cross‐Linking and Immunoprecipitation (CLIP) of Argonaute (Ago) is combined with
Lauren A. Gay, Peter C. Turner, Rolf Renne   +2 more
wiley   +1 more source