Results 21 to 30 of about 1,598 (170)

The infection of murine gammaherpesvirus-68 delays the early embryonic development of zebrafish

Reproduction and Breeding, 2023
Zebrafish is a model animal for aquaculture as well as bio-medicine. Murine gamma-herpesvirus 68 (MHV68) is widely regarded as a model for the study of human gamma herpesviruses such as Kaposi's sarcoma-associated herpesvirus (KSHV).
Jun Yan, Mengdie Chi, Jun Xiao, Meiling Liu, Hao Feng   +4 more
exaly   +3 more sources

Eph receptor tyrosine kinases are functional entry receptors for murine gammaherpesvirus 68. [PDF]

PLoS Pathogens
Interactions between viral glycoproteins and cellular receptors determine virus tropism and represent promising targets for vaccines. Eph receptor tyrosine kinases are conserved receptors for the human oncogenic gammaherpesviruses, Kaposi sarcoma ...
Anna K Großkopf, Victor Tobiasson, Laurie T Krug   +2 more
doaj   +2 more sources

CD95-CD95L interaction mediates the growth control of MHV68 immortalized B cells by cytotoxic T cells [PDF]

Virologica Sinica, 2017
In conclusion, our current data demonstrate that MHV68-immortalized SL-1 cells can be recognized and controlled by specific cytotoxic T cells through CD95/CD95L-mediated apoptosis. This is in agreement with that CD4 T cells control the growth of EBV-infected cells through CD95/CD95L-mediated apoptosis, which suggests that the growth control of ...
Xiaozhen Liang, Guifang Chen
exaly   +3 more sources

Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease [PDF]

Journal of Neuroinflammation
Background Growing evidence indicates that Epstein-Barr virus (EBV), a gammaherpesvirus, plays a central role in the pathogenesis of multiple sclerosis (MS).
Alexander Muselman, Sameera Kongara, Nathan Hsu, Asha Aggarwal, Joanna Yu, Jayakumar Rajadas, Edgar G. Engleman   +6 more
doaj   +2 more sources

CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

Cell Reports, 2012
To study the CD8(+) T cell response against a mouse γ-herpes virus, we generated K(b)-MHV-68-ORF8(604-612)RAG(-/-) CD8(+) T cell receptor transnuclear (TN) mice as a source of virus-specific CD8(+) T cells. K(b)-ORF8-Tet(+) CD8(+) T cells, expanded in the course of a resolving MHV-68 infection, served as a source of nucleus donors.
Sharvan Sehrawat, Paul-Albert Koenig, J Pedro Simas   +2 more
exaly   +7 more sources

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs [PDF]

mBio
Transfer RNAs (tRNAs) are fundamental for both cellular and viral gene expression during viral infection. In addition, mounting evidence supports the biological function for tRNA cleavage products, including the control of gene expression during ...
Aidan C. Manning, Mahmoud M. Bashir, Kyle Rapchak, Calyssa J. Huff, Ariana R. Jimenez, Sheila Gonzalez, Courtney L. Woodruff, Heather E. Upton, Kathleen Collins, Todd M. Lowe, Jessica M. Tucker   +10 more
doaj   +2 more sources

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection [PDF]

Viruses
Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein–Barr virus or Kaposi sarcoma herpesvirus.
Dipanwita Mitra, Darby G. Oldenburg, J. Craig Forrest, Laurie T. Krug   +3 more
doaj   +2 more sources

A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment [PDF]

npj Vaccines
Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved ...
Wesley A. Bland, Dipanwita Mitra, Shana Owens, Kyle McEvoy, Chad H. Hogan, Luciarita Boccuzzi, Varvara Kirillov, Thomas J. Meyer, Camille Khairallah, Brian S. Sheridan, J. Craig Forrest, Laurie T. Krug   +11 more
doaj   +2 more sources

Evaluation of immune sensor responses to a viral small noncoding RNA [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionGammaherpesviruses are widespread pathogens causing persistent infections linked to the development of numerous types of lymphomas in humans.
Mehmet Kara, Mehmet Kara, Scott A. Tibbetts   +2 more
doaj   +2 more sources

Preexisting helminth challenge exacerbates infection and reactivation of gammaherpesvirus in tissue resident macrophages.

PLoS Pathogens, 2023
Even though gammaherpesvirus and parasitic infections are endemic in parts of the world, there is a lack of understanding about the outcome of coinfection. In humans, coinfections usually occur sequentially, with fluctuating order and timing in different
Christina M Zarek, Chaitanya Dende, Jaime Coronado, Mihir Pendse, Phillip Dryden, Lora V Hooper, Tiffany A Reese   +6 more
doaj   +1 more source