Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection [PDF]
PLoS Pathogens, 2018 Gammaherpesvirus (GHV) pathogenesis is a complex process that involves productive viral replication, dissemination to tissues that harbor lifelong latent infection, and reactivation from latency back into a productive replication cycle.
Arundhati Gupta +2 more
exaly +3 more sources
PLoS Pathogens, 2019 The hypoxia-inducible factor 1 alpha (HIF1α) protein and the hypoxic microenvironment are critical for infection and pathogenesis by the oncogenic gammaherpesviruses (γHV), Kaposi sarcoma herpes virus (KSHV) and Epstein-Barr virus (EBV).
Darlah M Lopez-Rodriguez +2 more
exaly +4 more sources
Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs [PDF]
mBioTransfer RNAs (tRNAs) are fundamental for both cellular and viral gene expression during viral infection. In addition, mounting evidence supports the biological function for tRNA cleavage products, including the control of gene expression during ...
Aidan C. Manning +10 more
doaj +2 more sources
Tick-Borne Transmission of Murine Gammaherpesvirus 68
Frontiers in Cellular and Infection Microbiology, 2017 Herpesviruses are a large group of DNA viruses infecting mainly vertebrates. Murine gammaherpesvirus 68 (MHV68) is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as Epstein-Barr virus and Kaposi'
Marcela Kudelova +2 more
exaly +3 more sources
Animal models of human herpesvirus infection. [PDF]
Animal Model Exp MedHuman herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Jia Z, Zhang D, Zhu L, Xue J.
europepmc +2 more sources
Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection [PDF]
VirusesGammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein–Barr virus or Kaposi sarcoma herpesvirus.
Dipanwita Mitra +3 more
doaj +2 more sources
Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues [PDF]
mSphere, 2023 Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair.
Kyle R. Smith +7 more
doaj +2 more sources
Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus. [PDF]
Protein SciAbstract Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects a majority of the world population. It may cause severe disease in immunocompromised people and lead to pregnancy loss or grave disabilities of the fetus upon congenital infection.
Eberhage J +9 more
europepmc +2 more sources
A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment [PDF]
npj VaccinesGammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved ...
Wesley A. Bland +11 more
doaj +2 more sources
PLoS Pathogens, 2012 The Latency-Associated Nuclear Antigen (LANA), encoded by ORF73, is a conserved gene among the γ2-herpesviruses (rhadinoviruses). The Kaposi's Sarcoma-Associated Herpesvirus (KSHV) LANA is consistently expressed in KSHV-associated malignancies.
J Craig Forrest +2 more
exaly +3 more sources