The MHV68 M2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation [PDF]
PLoS Pathogens, 2008 Murine gammaherpesvirus 68 (MHV68) establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV). EBV encodes an interleukin-10 (IL-10) homolog and modulates cellular IL-10 expression; however, the role of
Samuel Speck
exaly +6 more sources
Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates [PDF]
MBioKaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 is an etiological agent of Kaposi’s Sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Considering the high seroprevalence reaching up to 80% in sub-Saharan Africa,
Jae Jung, Dokyun Kim, Chih-Jen Lai
exaly +6 more sources
Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection [PDF]
PLoS Pathogens, 2018 Gammaherpesvirus (GHV) pathogenesis is a complex process that involves productive viral replication, dissemination to tissues that harbor lifelong latent infection, and reactivation from latency back into a productive replication cycle.
Douglas W White +2 more
exaly +6 more sources
PLoS Pathogens, 2019 The hypoxia-inducible factor 1 alpha (HIF1α) protein and the hypoxic microenvironment are critical for infection and pathogenesis by the oncogenic gammaherpesviruses (γHV), Kaposi sarcoma herpes virus (KSHV) and Epstein-Barr virus (EBV).
Darlah Lopez-Rodriguez +2 more
exaly +6 more sources
Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection [PDF]
Frontiers in Microbiology, 2021 Investigating the dynamics of virus-host interactions in vivo remains an important challenge, often limited by the ability to directly identify virally infected cells.
Leslie J Berg +2 more
exaly +5 more sources
MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner [PDF]
Virology, 2010 Murine gammaherpesvirus-68 (MHV68) is genetically related to human Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus and provides a tractable model to study gammaherpesvirus-host interactions in vivo and in vitro. The MHV68-encoded v-RCA product inhibits murine complement activation and shares sequence homology with other virus and host ...
Herbert Virgin +2 more
exaly +4 more sources
A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection [PDF]
VaccinesBackground: It is still challenging to develop effective vaccines against tumorigenic human gammaherpesviruses such as Epstein–Barr virus (EBV). A major obstacle is the lack of a small animal model that reproduces the natural infection course of human ...
Zhong Huang +2 more
exaly +4 more sources
PLoS Pathogens, 2012 The Latency-Associated Nuclear Antigen (LANA), encoded by ORF73, is a conserved gene among the γ2-herpesviruses (rhadinoviruses). The Kaposi's Sarcoma-Associated Herpesvirus (KSHV) LANA is consistently expressed in KSHV-associated malignancies.
Scott Tibbetts +2 more
exaly +5 more sources
MHV68 Latency Modulates the Host Immune Response to Influenza A Virus [PDF]
Inflammation, 2013 Murine gammaherpesvirus 68 (MHV68) is a natural rodent pathogen that has been used as a model to study the pathogenesis of human gammaherpesviruses. Like other herpesviruses, MHV68 causes acute infection and establishes life-long latency in the host.
William F Carson +2 more
exaly +3 more sources
Repression of productive viral replication by KSHV LANA correlates with reduced adaptive immune activation: potential implications for KSHV immune evasion [PDF]
mBioAdaptive immune responses to primary Kaposi sarcoma-associated herpesvirus (KSHV) infection are poorly defined. To develop better small-animal models for understanding KSHV pathogenesis and immunity, we previously generated a chimeric virus in which the ...
Steven J. Murdock +3 more
doaj +2 more sources