Results 21 to 30 of about 7,920 (155)

Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host [PDF]

Journal of Virology
Lipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral infection has been less explored.
Damon L. Schmalzriedt, Erika R. Johansen, Carlie A. Aurubin, Cade R. Rahlf, Bradey Stuart, Daisy Sahoo, Vera L. Tarakanova   +6 more
doaj   +2 more sources

Genome-wide Transcript Structure Resolution Reveals Abundant Alternate Isoform Usage from Murine Gammaherpesvirus 68

Cell Reports, 2019
Summary: The gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, MuHV-4, γHV68), are etiologic agents of a wide range of lymphomas and non-hematological ...
Scott Tibbetts, Tina M O'Grady, Yiping Wang   +2 more
exaly   +3 more sources

Gammaherpesvirus RNAs Come Full Circle

mBio, 2019
After an adaptive immune response is mounted, gammaherpesviruses achieve persistence through the utilization of viral noncoding RNAs to craft a suitable host cell environment in an immunologically transparent manner. While gammaherpesvirus long noncoding
Nathan A. Ungerleider, Scott A. Tibbetts, Rolf Renne, Erik K. Flemington   +3 more
doaj   +2 more sources

Detection of Ursid Gammaherpesvirus 2 in Asiatic Black Bears (Ursus thibetanus) With Keratoconjunctivitis. [PDF]

Vet Ophthalmol
ABSTRACT Objective To investigate the potential contribution of herpesvirus infection in the development of ocular surface disease in Asiatic black bears (Ursus thibetanus). Animals Studied Eight captive Asiatic black bears housed at a wildlife sanctuary were examined during routine health assessments.
Thieme K, Gölkel M, Eule JC, Halter-Gölkel L, Kunec D, Göritz F, Feyer S, Bui BN, Trimpert J.   +8 more
europepmc   +2 more sources

Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages [PDF]

Journal of Virology
Gammaherpesviruses establish lifelong infections in over 90% of adults worldwide and contribute to the development of several cancers. Endogenous lipid synthesis pathways support lytic and latent life cycles of several gammaherpesviruses.
Damon L. Schmalzriedt, Carlie A. Aurubin, Cade R. Rahlf, Matthew A. Brown, Jordan M. Bobek, Philip T. Lange, Xander G. Bradeen, Daisy Sahoo, Vera L. Tarakanova   +8 more
doaj   +2 more sources

RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency

Pathogens, 2017
RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene expression upon de novo infection and reactivation from latency.
Qiwen Dong, Laraib Malik, Douglas W White   +2 more
exaly   +3 more sources

A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment [PDF]

npj Vaccines
Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved ...
Wesley A. Bland, Dipanwita Mitra, Shana Owens, Kyle McEvoy, Chad H. Hogan, Luciarita Boccuzzi, Varvara Kirillov, Thomas J. Meyer, Camille Khairallah, Brian S. Sheridan, J. Craig Forrest, Laurie T. Krug   +11 more
doaj   +2 more sources

Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment

Nature Communications
Gammaherpesviruses are DNA tumor viruses that establish lifelong latent infections in lymphocytes. For viruses such as Epstein-Barr virus and murine gammaherpesvirus 68, this is accomplished through a viral gene-expression program that promotes cellular ...
Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest   +10 more
doaj   +2 more sources

Packaging of viral microRNAs in gammaherpesvirus 68 [PDF]

, 2013
MicroRNAs are a characteristic of many herpesvirus genomes. These short, non-coding RNAs are capable of post-transcriptional regulation of target mRNAs. Recently, packaged miRNAs have been observed in purified virions of EBV and KSHV, gammaherpesviruses ...
Lutz, Jessica
core   +8 more sources

The innate and T-cell mediated immune response during acute and chronic gammaherpesvirus infection

Frontiers in Cellular and Infection Microbiology, 2023
Immediately after entry into host cells, viruses are sensed by the innate immune system, leading to the activation of innate antiviral effector mechanisms including the type I interferon (IFN) response and natural killer (NK) cells.
Viktoria Rex, Razieh Zargari, Markus Stempel, Markus Stempel, Stephan Halle, Stephan Halle, Melanie M. Brinkmann, Melanie M. Brinkmann   +7 more
doaj   +1 more source