Results 21 to 30 of about 7,401 (195)

Alteration of the Premature tRNA Landscape by Gammaherpesvirus Infection [PDF]

mBio, 2020
Transfer RNAs (tRNAs) are transcribed by RNA polymerase III (RNAPIII) and play a central role in decoding our genome, yet their expression and noncanonical function remain understudied.
Jessica M. Tucker, Aaron M. Schaller, Ian Willis, Britt A. Glaunsinger   +3 more
doaj   +3 more sources

Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection. [PDF]

PLoS ONE, 2012
Herpesviruses are characterized by their ability to establish lifelong latent infection. The gammaherpesvirus subfamily is distinguished by lymphotropism, establishing and maintaining latent infection predominantly in B lymphocytes.
Kathleen S Gray, Christopher M Collins, Samuel H Speck   +2 more
doaj   +2 more sources

Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection

mBio
Gammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong infection in their hosts and are associated with cancers, including B cell lymphomas. Type I and II interferons (IFNs) are critical for the control of acute and chronic
Erika R. Johansen, Damon L. Schmalzriedt, Danilela Avila, Paul A. Sylvester, Cade R. Rahlf, Jordan M. Bobek, Daisy Sahoo, Bonnie N. Dittel, Vera L. Tarakanova   +8 more
doaj   +2 more sources

Characterization of Murine Gammaherpesvirus 68 Glycoprotein B [PDF]

Journal of Virology, 2004
ABSTRACT Murine gammaherpesvirus 68 (MHV-68) glycoprotein B (gB) was identified in purified virions by immunoblotting, immunoprecipitation, and immunoelectron microscopy. It was synthesized as a 120-kDa precursor in infected cells and cleaved into 65-kDa and 55-kDa disulfide-linked subunits close to the time of virion release.
Lopes, Filipa B., Colaco, Susanna, May, Janet S., Stevenson, Philip G.   +3 more
openaire   +7 more sources

Model Systems of Gammaherpesvirus Infection, Immunity, and Disease. [PDF]

J Med Virol
ABSTRACT Epstein‐Barr virus (EBV) and Kaposi's sarcoma‐associated herpesvirus (KSHV) are oncogenic human gammaherpesviruses (GHVs) associated with a broad spectrum of malignancies and chronic diseases. However, direct studies of these viruses in humans are limited by ethical constraints, technical challenges, and their strict species specificity.
Gupta A, Li R, Shair K, Gao SJ.
europepmc   +2 more sources

Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes. [PDF]

PLoS Pathogens, 2009
Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as several other types of cancer.
Xiaozhen Liang, Christopher M Collins, Justin B Mendel, Neal N Iwakoshi, Samuel H Speck   +4 more
doaj   +2 more sources

Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment

Nature Communications
Gammaherpesviruses are DNA tumor viruses that establish lifelong latent infections in lymphocytes. For viruses such as Epstein-Barr virus and murine gammaherpesvirus 68, this is accomplished through a viral gene-expression program that promotes cellular ...
Shana M. Owens, Jeffrey M. Sifford, Gang Li, Steven J. Murdock, Eduardo Salinas, Darby Oldenburg, Debopam Ghosh, Jason S. Stumhofer, Intawat Nookaew, Mark Manzano, J. Craig Forrest   +10 more
doaj   +2 more sources

A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment

npj Vaccines
Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved ...
Wesley A. Bland, Dipanwita Mitra, Shana Owens, Kyle McEvoy, Chad H. Hogan, Luciarita Boccuzzi, Varvara Kirillov, Thomas J. Meyer, Camille Khairallah, Brian S. Sheridan, J. Craig Forrest, Laurie T. Krug   +11 more
doaj   +2 more sources

Gammaherpesvirus Infections in Cattle in Europe [PDF]

Viruses, 2021
The genus Macavirus, subfamily Gammaherpesvirinae, comprises ungulate viruses that infect domestic and wild ruminants and swine. They cause asymptomatic latent infections in reservoir hosts and malignant catarrhal fever in susceptible species. Lung, spleen, bronchial lymph node, and tongue were collected from 448 cattle (348 necropsied, 100 slaughtered)
Rosato, Giuliana, Ruiz Subira, Andres, Al-Saadi, Mohammed, Michalopoulou, Eleni, Verin, Ranieri, Dettwiler, Martina, Nordgren, Heli, Chiers, Koen, Groβmann, Ernst, Köhler, Kernt, Suntz, Michael, Stewart, James P, Kipar, Anja   +12 more
openaire   +6 more sources

A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection [PDF]

Journal of Virology, 2009
ABSTRACT Murine gammaherpesvirus 68 (MHV-68) contains a ubiquitin (Ub)-specific cysteine protease (USP) domain embedded within the large tegument protein ORF64, as do all other herpesviruses. The biological role of this protease is still unclear, but for the alphaherpesvirus Marek's disease virus, its USP is involved in T-cell lymphoma ...
Sara, Gredmark-Russ, Marisa K, Isaacson, Lisa, Kattenhorn, Evelyn J, Cheung, Nicki, Watson, Hidde L, Ploegh   +5 more
openaire   +2 more sources