Results 41 to 50 of about 7,920 (155)

Validation and characterization of murine gammaherpesvirus 68 antisense transcripts by northern blot analysis and quantitative reverse transcription-PCR [PDF]

Archives of Biological Sciences, 2023
The transcription of mammalian genomes exhibits an intriguing complexity and numerous novel RNA molecules have been identified. Viruses with large DNA genomes, especially herpesviruses, generate many different RNA species, including long non-coding RNAs (
Kara Mehmet
doaj   +1 more source

Dangerous Liaisons: Gammaherpesvirus Subversion of the Immunoglobulin Repertoire

Viruses, 2020
A common biologic property of the gammaherpesviruses Epstein–Barr Virus and Kaposi sarcoma herpesvirus is their use of B lymphocytes as a reservoir of latency in healthy individuals that can undergo oncogenic transformation later in life ...
Monika A. Zelazowska, Kevin McBride, Laurie T. Krug   +2 more
doaj   +1 more source

Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection. [PDF]

PLoS ONE, 2012
Herpesviruses are characterized by their ability to establish lifelong latent infection. The gammaherpesvirus subfamily is distinguished by lymphotropism, establishing and maintaining latent infection predominantly in B lymphocytes.
Kathleen S Gray, Christopher M Collins, Samuel H Speck   +2 more
doaj   +1 more source

Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo [PDF]

, 2010
Many herpesvirus-encoded protein kinases facilitate viral lytic replication. Importantly, the role of viral kinases in herpesvirus latency is less clear. Mouse gammaherpesvirus-68 (MHV68)-encoded protein kinase orf36 facilitates lytic replication in part
Vera L. Tarakanova, Stephen B. Gauld, Bigley, Tarin M., Leonardo, Steven M., Tarin M. Bigley, Stanitsa, Eleni, Tarakanova, Vera L., Steven M. Leonardo, Gauld, Stephen B., Eleni Stanitsa   +9 more
core   +1 more source

OvHV-2 Glycoprotein B Delivered by a Recombinant BoHV-4 Is Immunogenic and Induces Partial Protection against Sheep-Associated Malignant Catarrhal Fever in a Rabbit Model

Vaccines, 2021
An efficacious vaccine for sheep-associated malignant catarrhal fever (SA-MCF) is important for the livestock industry. Research towards SA-MCF vaccine development is hindered by the absence of culture systems to propagate the causative agent, ovine ...
Smriti Shringi, Donal O’Toole, Emily Cole, Katherine N. Baker, Stephen N. White, Gaetano Donofrio, Hong Li, Cristina W. Cunha   +7 more
doaj   +1 more source

Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes. [PDF]

PLoS Pathogens, 2009
Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as several other types of cancer.
Xiaozhen Liang, Christopher M Collins, Justin B Mendel, Neal N Iwakoshi, Samuel H Speck   +4 more
doaj   +1 more source

Gammaherpesvirus Alters Alveolar Macrophages According to the Host Genetic Background and Promotes Beneficial Inflammatory Control over Pneumovirus Infection

Viruses, 2022
Human respiratory syncytial virus (hRSV) infection brings a wide spectrum of clinical outcomes, from a mild cold to severe bronchiolitis or even acute interstitial pneumonia. Among the known factors influencing this clinical diversity, genetic background
Gautier Gilliaux, Daniel Desmecht
doaj   +1 more source

Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection

mBio
Gammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong infection in their hosts and are associated with cancers, including B cell lymphomas. Type I and II interferons (IFNs) are critical for the control of acute and chronic
Erika R. Johansen, Damon L. Schmalzriedt, Danilela Avila, Paul A. Sylvester, Cade R. Rahlf, Jordan M. Bobek, Daisy Sahoo, Bonnie N. Dittel, Vera L. Tarakanova   +8 more
doaj   +1 more source

Gammaherpesvirus in Cervid Species from Norway: Characterization of a New Virus in Wild and Semi-Domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus)

Viruses, 2020
Gammaherpesvirus infections have been described in cervids worldwide, mainly the genera Macavirus or Rhadinovirus. However, little is known about the gammaherpesviruses species infecting cervids in Norway and Fennoscandia.
Carlos G. das Neves, Carlos Sacristán, Knut Madslien, Morten Tryland   +3 more
doaj   +1 more source

Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival

mBio, 2021
Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the de novo pyrimidine synthesis pathway enzyme cytidine 5′ triphosphate synthase 1 (CTPS1) suppress cell-
Jin Hua Liang, Chong Wang, Stephanie Pei Tung Yiu, Bo Zhao, Rui Guo, Benjamin E. Gewurz   +5 more
doaj   +1 more source