Results 51 to 60 of about 8,076 (157)

The Developmental and Functional Implications of Age‐Associated B Cells (ABCs) Across Tissue Microenvironments

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a dynamic B cell subset whose identity, development, and function are fundamentally shaped by the tissue microenvironments in which they reside. Primarily defined by expression of CD11c and T‐bet, ABCs arise across diverse contexts, including aging, infection, autoimmunity, and cancer, yet exhibit striking ...
Rebecca L. Francis, Jason S. Weinstein
wiley   +1 more source

Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages

Journal of Virology
Gammaherpesviruses establish lifelong infections in over 90% of adults worldwide and contribute to the development of several cancers. Endogenous lipid synthesis pathways support lytic and latent life cycles of several gammaherpesviruses.
Damon L. Schmalzriedt, Carlie A. Aurubin, Cade R. Rahlf, Matthew A. Brown, Jordan M. Bobek, Philip T. Lange, Xander G. Bradeen, Daisy Sahoo, Vera L. Tarakanova   +8 more
doaj   +1 more source

Long Non-coding RNAs in Gammaherpesvirus Infections: Their Roles in Tumorigenic Mechanisms

Frontiers in Microbiology, 2021
Long non-coding RNAs (lncRNAs) regulate gene expression at the epigenetic, transcriptional, or posttranscriptional level by interacting with protein, DNA, and RNA.
Wen Liu, Yan Zhang, Yan Zhang, Bing Luo
doaj   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, Volume 13, Issue 31, 4 June 2026.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

First metagenomic detection and partial genomic characterization of Bossavirus delphinidgamma1 in captive common bottlenose dolphins in Southeast Asia [PDF]

Veterinary World
Background and Aim: Bossavirus delphinidgamma1 is a dolphin-associated gammaherpesvirus for which genomic information from tropical Asian marine mammal populations remains scarce.
Augustine Natasha, Annisa Wening Maharani Putri, Nunak Nafiqoh, Sara Puspareni Prayitno, Lila Gardenia, Hessy Novita, Tanjung Penataseputro, Agustin Indrawati, Desy Sugiani, Uni Purwaningsih, Tuti Sumiati, Dewi Syahidah, Rifky Rizkiantino, Ji Eun Park, Harimurti Nuradji, Angela Mariana Lusiastuti, Won-Keun Kim   +16 more
doaj   +1 more source

Alteration of the Premature tRNA Landscape by Gammaherpesvirus Infection

mBio, 2020
Transfer RNAs (tRNAs) are transcribed by RNA polymerase III (RNAPIII) and play a central role in decoding our genome, yet their expression and noncanonical function remain understudied.
Jessica M. Tucker, Aaron M. Schaller, Ian Willis, Britt A. Glaunsinger   +3 more
doaj   +1 more source

Case Report: Synchronous Manifestations of Kaposi Sarcoma Herpesvirus‐Associated Disorders

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Kaposi sarcoma herpes virus (KSHV) is associated with multiple clinical manifestations, including primary effusion lymphoma, an aggressive CD38+ B cell lymphoma with a plasmablastic phenotype. Case This case describes an antiretroviral therapy‐adherent person with HIV who presented with concurrent KSHV‐related disorders of Kaposi ...
Kandice Roberts, Paula Valiño Ramos, Saurabh Jindal, Vikas Prasad, Yi Shan Lee, Mariam Khanfar, Obi L. Griffith, Malachi Griffith, Jeanne Jiang, Ethel Cesarman, Daniel Rauch, Paul Simonson, Thomas Odeny, Lee Ratner   +13 more
wiley   +1 more source

DESIGN AND GENERATION OF A RECOMBINANT GAMMAHERPESVIRUS ENCODING shRNA FROM A NATIVE VIRAL tRNA PROMOTER

Trakya University Journal of Natural Sciences, 2023
Gammaherpesviruses are associated with multiple types of tumor development and understanding the pathogenesis of these viruses has been the subject of various studies.
Scott Tibbetts, Mehmet Kara
doaj   +1 more source

KSHV Genome in Saliva, Whole Blood and Kaposi's Sarcoma Biopsy Specimens in Republic of Congo: Phylogenetic Analysis and an APOBEC3B Mutational Signature

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) has been associated with a variety of diseases and is endemic in Sub‐Saharan Africa. We performed KSHV‐whole‐genome analysis and search for APOBEC‐editing to describe genetic diversity in samples issued from an endemic region.
Gervillien Arnold Malonga, Valentin Leducq, Antoine Fauchois, Dimitry Moudiongui Mboungou Malanda, Patrina Joseph Iloukou Mayakia, Juthèce Private Malanda‐Kiminou, Ferdinand Emaniel Brel Got, Fabien Gaël Mouamba, Vincent Calvez, Jean Felix Peko, Anne‑Geneviève Marcelin, Aude Jary   +11 more
wiley   +1 more source

Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo

mBio, 2016
A challenging property of gammaherpesviruses is their ability to establish lifelong persistence. The establishment of latency in B cells is thought to involve active virus engagement of host signaling pathways.
Sandeep Steven Reddy, Hui-Chen Chang Foreman, Thubten Ozula Sioux, Gee Ho Park, Valeria Poli, Nancy C. Reich, Laurie T. Krug   +6 more
doaj   +1 more source