Results 71 to 80 of about 8,076 (157)

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection

Viruses
Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein–Barr virus or Kaposi sarcoma herpesvirus.
Dipanwita Mitra, Darby G. Oldenburg, J. Craig Forrest, Laurie T. Krug   +3 more
doaj   +1 more source

Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis

Pathogens, 2020
Epstein−Barr virus (EBV) is involved in the pathogenesis of various lymphomas and carcinomas, whereas Kaposi’s sarcoma-associated herpesvirus (KSHV) participates in the pathogenesis of endothelial sarcoma and lymphomas.
Shigeyoshi Fujiwara, Hiroyuki Nakamura
doaj   +1 more source

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity

European Journal of Immunology, Volume 56, Issue 2, February 2026.
EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B‐cell repertoire and promotes the oligoclonal expansion and subsequent CNS infiltration of T‐bet+CXCR3+ B cells, resulting in a cascade of immune dysregulation, CNS inflammation,
Fabienne Läderach, Elena Bremer, Christian Münz   +2 more
wiley   +1 more source

Assessing Nanopore Targeted Sequencing for the Diagnosis of Pulmonary Infections: A Comparative Multidisease Approach

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Pulmonary infections remain a significant global health burden, particularly in immunocompromised individuals and patients with chronic respiratory or systemic diseases. Conventional microbiological tests (CMTs), though widely used, often have limited sensitivity and delayed results, especially in polymicrobial or atypical infections.
Ying Zhao, Guannan Ma, Tianxiao Ma, Yongshuai Miao, Heya Na, Yuhui Liu, Xiaohua Li, Arif Ansori   +7 more
wiley   +1 more source

Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract [PDF]

, 2015
This work was supported by a Royal Society (London) University Research Fellowship (to JPS), by Biotechnology and Biological Sciences Research Council (UK) grants BB/K009664/1 (to JPS, AK, and GHL) and BB/K009737/1 (CDB and LB), US Public Health Service ...
Leeming, G H, Moyo, NA, Bingle, Colin D, Bigley, A.L., Tripp, Ralph A, Bennett, E., Hughes, D J, Leeming, G.H., Moyo, N A, Bingle, L, Bigley, AL, Sample, JT, Bigley, Alison L, Bigley, A L, Tripp, R A, Sample, J T, Kipar, A, Moyo, Nathifa A, Stewart, JP, Stewart, J.P., Bennett, E, Tripp, R.A., Hughes, DJ, Kipar, A., Tripp, RA, Stewart, James P, Bingle, Lynne, Bennett, Elaine, Hughes, D.J., Leeming, Gail H, Sample, Jeffery T, Bingle, C D, Leeming, GH, Moyo, N.A., Sample, J.T., Hughes, David J, Kipar, Anja, Bingle, CD, Bingle, L., Bingle, C.D., Stewart, J P, Sample JT, Hughes DJ, Leeming GH, Kipar A, Bigley AL, Bingle L, Tripp RA, Bingle CD, Bennett E, Stewart JP, Moyo NA, Hughes, David J; id_orcid   +52 more
core   +1 more source

Towards Integrated Surveillance of Marine Brucellosis: Diagnostic and Phylogenetic Assessment of Brucella ceti in Stranded Dolphins of the Western Mediterranean Sea

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Reports of brucellosis in free‐ranging cetaceans are increasing worldwide, particularly in the Mediterranean Sea. To enhance diagnostic accuracy and epidemiological understanding of cetacean brucellosis in the Western Mediterranean Sea, we analyzed bacteriological, serological, and molecular data from 30 cetaceans belonging to three different species ...
Ignacio Vargas-Castro, Sara Andrés-Barranco, José Luis Crespo-Picazo, Laura Torre-Fuentes, Mª Ángeles Jiménez-Martínez, Marta Hernández, Manuel Arbelo, Julio Álvarez, Pilar María Muñoz, Vicente Marco-Cabedo, María Jesús de Miguel, Débora López, Marta Muñoz-Baquero, Daniel García-Párraga, José Ángel Barasona, Zongfu Wu   +15 more
wiley   +1 more source

Humanized Mouse Models of Epstein Barr Virus Infection

Current Protocols, Volume 5, Issue 11, November 2025.
Abstract The oncogenic Epstein Barr virus (EBV) is an exclusively human pathogen with related lymphocryptoviruses (γ1‐herpesviruses) only present in monkeys. Therefore, experimentation with EBV infection in a small animal model requires reconstitution or adoptive transfer of human lymphocyte populations, primarily EBV's main host cell, the human B cell.
Saskia Gertrud von Boxberg, Kristin Gehrmann, Svenja Luisa Nopper, Lucas Romann, Svenja Kösegi, Christian Münz   +5 more
wiley   +1 more source

Phylogenetic tree of Otarine gammaherpesvirus DNA polymerase gene.

Phylogenetic relationships of the DNA polymerase gene of Otarine gammaherpesvirus 1 (OtGHV1) and Otarine gammaherpesvirus 8 (OtGHV8) detected in South American fur seals (Arctocephalus australis) and South American sea lions (Otaria byronia ...
Matthew C. Allender (7871711), Alissa C. Deming (9753188), Karisa N. Tang (18114776), Susana Cárdenas-Alayza (4175575), Michael J. Adkesson (7042700), Galaxia Cortes-Hinojosa (18114782), Jennifer N. Langan (7042706), Kathleen Colegrove (18114785), James F. X. Wellehan (3192669), Laura Adamovicz (5067095), April Childress (18114779)   +10 more
core   +1 more source

Phylogenetic tree of Otarine gammaherpesvirus glycoprotein b gene.

Phylogenetic relationships of the glycoprotein b gene of Otarine gammaherpesvirus 1 (OtGHV1) and Otarine gammaherpesvirus 8 (OtGHV8) detected in South American fur seals (Arctocephalus australis) and South American sea lions (Otaria byronia ...
Matthew C. Allender (7871711), Alissa C. Deming (9753188), Karisa N. Tang (18114776), Susana Cárdenas-Alayza (4175575), Michael J. Adkesson (7042700), Galaxia Cortes-Hinojosa (18114782), Jennifer N. Langan (7042706), Kathleen Colegrove (18114785), James F. X. Wellehan (3192669), Laura Adamovicz (5067095), April Childress (18114779)   +10 more
core   +1 more source

Regulation of Host and Viral RNA Expression during Gammaherpesvirus Infection [PDF]

, 2015
Gammaherpesviruses are oncogenic viruses that establish latent infection and can periodically reactivate. Replication, reactivation from latency and gammaherpesvirus-mediated pathology are regulated by viral and host factors.
Canny, Susan Priscilla
core   +1 more source