Results 41 to 50 of about 4,224,412 (338)

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]

, 2000
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ, Rajko Reljic (406091), Rajko Reljic, Reljic, R, Fearon, DT, Simon D. Wagner, Luke J. Peakman, Luke J. Peakman (7768292), Fearon, D T, Douglas T. Fearon, Wagner, S D, Wagner, SD, Simon D. Wagner (7633943), Douglas T. Fearon (7768295), Peakman, L J   +14 more
core   +1 more source

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome

Journal of Experimental Medicine, 2020
Single-cell transcriptomic analysis of germinal center B cells identifies multiple linked populations, most of which represent cell of origin of lymphomas.
A. Holmes, C. Corinaldesi, Qiong Shen, Rahul Kumar, Nicolò Compagno, Zhong Wang, M. Nitzan, E. Grunstein, L. Pasqualucci, R. Dalla-Favera, K. Basso   +10 more
semanticscholar   +1 more source

Chemokine microenvironment in primary central nervous system lymphoma [PDF]

, 2010
Primary central nervous system lymphomas (PCNSL) are aggressive extranodal malignancies confined to the central nervous system (CNS), mostly of diffuse large B cell histotype.
Venetz, Daniel
core   +1 more source

Correlation between Germinal Center Differentiation and Double/Triple Hit Score in the Classification of Diffuse Large B Cell Non-Hodgkin Lymphoma: A Clinicopathological Approach

Asian Pacific Journal of Cancer Care, 2023
Background: Diffuse large B cell lymphoma (DLBCL) is considered the most common type of non-Hodgkin lymphoma. The global incidence of DLBCL has been doubled in the past decades, highlighting the need for more effective treatment regimens.
Israa Sobhy Abdel Razek Okap, Hanan Yehia Ahmed Tayel, Amany Abd El-Bary Abd El-Latif, Dalia Ahmed Mohamed Nafea, Nagwa Abdel Razek Mashali   +4 more
doaj   +1 more source

Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma.

Journal of Clinical Oncology, 2019
PURPOSE Ibrutinib has shown activity in non-germinal center B-cell diffuse large B-cell lymphoma (DLBCL). This double-blind phase III study evaluated ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in ...
A. Younes, L. Sehn, P. Johnson, P. Zinzani, X. Hong, Jun Zhu, C. Patti, D. Belada, O. Samoilova, C. Suh, S. Leppä, S. Rai, M. Turgut, W. Jurczak, Matthew Cheung, R. Gurion, S. Yeh, A. López‐Hernandez, U. Dührsen, C. Thieblemont, C. Chiattone, S. Balasubramanian, J. Carey, Grace Liu, S. Shreeve, Steven Sun, S. Zhuang, J. Vermeulen, L. Staudt, W. Wilson   +29 more
semanticscholar   +1 more source

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

Nature Immunology, 2020
Efficient generation of germinal center (GC) responses requires directed movement of B cells between distinct microenvironments underpinned by specialized B cell–interacting reticular cells (BRCs).
N. Pikor, U. Mörbe, M. Lütge, C. Gil-Cruz, C. Perez-Shibayama, M. Novkovic, Hung-Wei Cheng, C. Nombela-Arrieta, T. Nagasawa, M. Linterman, L. Onder, B. Ludewig   +11 more
semanticscholar   +1 more source

Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome [PDF]

, 1998
Structures resembling germinal centers are seen in the salivary glands of patients with Sjögren's syndrome, but it is not known whether the microenvironment of these cell clusters is sufficient for the induction of a germinal center response.
G Steinhauser, M Hummel, D I Stott, C Berek, Hiepe, F., Berek, C., F Hiepe, Hummel, M., Steinhauser, G., Stott, D.I.   +9 more
core   +1 more source

Data_Sheet_1_Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses.pdf [PDF]

, 2019
The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Sebastian C. Binder (5733092), Michael Meyer-Hermann (124166), Theinmozhi Arulraj (5369465), Philippe A. Robert (7350209)   +3 more
core   +1 more source

Antibody affinity shapes the choice between memory and germinal center B cell fates

Cell, 2020
Summary Immunological memory is required for protection against repeated infections and is the basis of all effective vaccines. Antibodies produced by memory B cells play an essential role in many of these responses. We have combined lineage tracing with
Charlotte Viant, G. Weymar, A. Escolano, Spencer T Chen, Harald Hartweger, M. Cipolla, Anna Gazumayan, M. Nussenzweig   +7 more
semanticscholar   +1 more source