Results 51 to 60 of about 4,224,412 (338)
Impact of dose-dense immunochemotherapy on prognosis of germinal center and non germinal center origin of diffuse large B cell lymphoma. [PDF]
, 2011 Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. Gene-expression profiling in DLCBL has brought insight into the biological heterogeneity of the disease. Two major subgroups have been identified: germinal center B (
B. Puccini +7 more
core +3 more sources
Jurnal Berita Ilmu Keperawatan, 2008 Stress is a non specific respone of body if the deman of body increase cause a stressor. Stress will increase sympathetic activity with releasing apinephrine and cortisol.
Siti Arifah, Okti Sri Purwanti
doaj +1 more source
The Biology of the Germinal Center [PDF]
Hematology, 2007 The immune system requires the production of high affinity antibodies of different subclasses to accomplish its many effector functions. Specific steps in B-cell ontogeny that occur within germinal centers of secondary lymphoid organs create much of the diversity in the immune system.
openaire +2 more sources
Reduced germinal center response in IL-21R-/- mice. [PDF]
, 2015 Mice were infected intranasally with 1,000 pfu of MHV68-H2bYFP and splenocytes were harvested at the indicated time points. (A) Representative flow plots showing reduced germinal center B cells in IL-21R-/- mice. Flow plots were gated on CD3-, CD4-, CD8-,
Samuel H. Speck (70359) +1 more
core +1 more source
Journal of Clinical Oncology, 2019 PURPOSE High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2)
Daisuke Ennishi +29 more
semanticscholar +1 more source
T follicular helper cells in germinal center B cell selection and lymphomagenesis
Immunological Reviews, 2020 Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long‐lived plasma cells.
M. Mintz, J. Cyster
semanticscholar +1 more source
An analysis of B cell selection mechanisms in germinal centres [PDF]
, 2005 Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell receptors with improved binding characteristics for the antigen ...
Meyer-Hermann, ME +6 more
core +2 more sources
A Theory of Germinal Center B Cell Selection, Division, and Exit
Cell Reports, 2012 High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments.
Michael Meyer-Hermann +5 more
doaj +1 more source
Haematologica, 2021 Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNA (eRNA) that can regulate transcription of target genes by means of in cis as ...
Sara Napoli +17 more
doaj +1 more source
VMP001-NP immunization triggers germinal center formation. [PDF]
, 2013 (A) C57Bl/6 mice were vaccinated with 0.1 µg VMP001 and 5 µg MPLA in either soluble or VMP001-NP formulations, and on day 21, inguinal dLNs were isolated and analyzed for germinal center formation.
Darrell J. Irvine (333609) +5 more
core +1 more source