Results 61 to 70 of about 72,003 (345)

Studies on Germinal Center Biology [PDF]

, 2017
The germinal center reaction is at the heart of the humoral immune response; it comprises one major arm of the immune system, with the other arm being the cellular response. It is the site where B cells undergo somatic hyper-mutation, class switching,
Sarmiento, Selina
core  

Impact of dose-dense immunochemotherapy on prognosis of germinal center and non germinal center origin of diffuse large B cell lymphoma.

, 2011
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. Gene-expression profiling in DLCBL has brought insight into the biological heterogeneity of the disease. Two major subgroups have been identified: germinal center B (
B. Puccini, A. Bosi, S. Di Lollo, M. Doria, MARTELLI, Maurizio, L. Iovino, L. Rigacci, Erica Finolezzi   +7 more
core   +2 more sources

B and T Cell Interplay, Germinal Center Dynamics and Role of Regulatory T Cells (Tregs) in B Cell Modulation and Immune Tolerance: A Narrative Review

Immuno
T cells and B cells are central components of the adaptive immune system, orchestrating immune responses through a complex network of interactions.
Mohammad Shahid Iqbal, Ahmad F. Arbaeen, M. A. Bendary, Hasan H. Qadi, Aisha Tabassum, Othman M. Fallatah, Sami Melebari, Nadeem Ikram, Mohammed Parvez, Kamal H. Alzabeedi   +9 more
doaj   +1 more source

A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells. [PDF]

PLoS ONE, 2018
A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented.
Vinod Krishna, Kurtis E Bachman
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection

mBio
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with the development of cancer and multiple sclerosis.
Erika R. Johansen, Xander G. Bradeen, Emily V. Xie, Bonnie N. Dittel, Elizabeth A. Leadbetter, Vera L. Tarakanova   +5 more
doaj   +1 more source

Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas

Diagnostic Pathology, 2011
Background Recently, human germinal center-associated lymphoma (HGAL) gene protein has been proposed as an adjunctive follicular marker to CD10 and BCL6. Methods Our aim was to evaluate immunoreactivity for HGAL in 82 cases of follicular lymphomas (FLs) -
Rubini Corrado, Stramazzotti Daniela, Giantomassi Federica, Costagliola Antonello, Zizzi Antonio, Lucarini Guendalina, Goteri Gaia, Leoni Pietro   +7 more
doaj   +1 more source

Smad1 Expression in Follicular Lymphoma [PDF]

Journal of Pathology and Translational Medicine, 2015
Background: Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center ...
Jai Hyang Go
doaj   +1 more source

Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification

Cell Reports, 2022
Summary: A main feature of Wiskott-Aldrich syndrome (WAS) is increased susceptibility to autoimmunity. A key contribution of B cells to development of these complications has been demonstrated through studies of samples from affected individuals and ...
Marc Descatoire, Remi Fritzen, Samuel Rotman, Genevieve Kuntzelman, Xavier Charles Leber, Stephanie Droz-Georget, Adrian J. Thrasher, Elisabetta Traggiai, Fabio Candotti   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source