Results 61 to 70 of about 4,224,412 (338)

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

Journal of Experimental Medicine, 2020
Inoue et al. show that a small population of germinal center–derived CD38intBcl6hi/intEfnb1+ cells with lower mTORC1 activity favors a memory B cell fate.
Takeshi Inoue, Ryo Shinnakasu, Chie Kawai, W. Ise, Eiryo Kawakami, N. Sax, T. Oki, T. Kitamura, Kazuo Yamashita, H. Fukuyama, T. Kurosaki   +10 more
semanticscholar   +1 more source

A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype

Haematologica, 2012
Background A phase II trial of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA-EPOCH-R) from the National Cancer Institute showed promising activity in untreated diffuse large B-cell lymphoma.
Wyndham H. Wilson, Sin-Ho Jung, Pierluigi Porcu, David Hurd, Jeffrey Johnson, S. Eric Martin, Myron Czuczman, Raymond Lai, Jonathan Said, Amy Chadburn, Dan Jones, Kieron Dunleavy, George Canellos, Andrew D. Zelenetz, Bruce D. Cheson, Eric D. Hsi   +15 more
doaj   +1 more source

microRNA Fine-Tuning of the Germinal Center Response

Frontiers in Immunology, 2021
Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma ...
Teresa Fuertes, Irene Salgado, Virginia G. de Yébenes, Virginia G. de Yébenes   +3 more
doaj   +1 more source

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

JCI Insight, 2020
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mechanisms underpinning this effect remain poorly defined.
Hannah G. Kelly, Hyon-Xhi Tan, J. Juno, R. Esterbauer, Yi Ju, Wenbo Jiang, Verena C. Wimmer, Brigette C. Duckworth, J. Groom, F. Caruso, M. Kanekiyo, S. Kent, A. Wheatley   +12 more
semanticscholar   +1 more source

A mathematical model for germinal centre kinetics and affinity maturation [PDF]

, 2002
We present a mathematical model which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immune response and on affinity maturation observed during the reaction.
DAGMAR IBER, PHILIP K. MAINI, Maini, P. K., Iber, D., Maini, Philip, Maini, PK, Iber, D   +6 more
core   +2 more sources

Selenium saves ferroptotic TFH cells to fortify the germinal center [PDF]

, 2021
Inhibition of ferroptosis via selenium supplementation promotes the survival of follicular helper T cells, boosting the germinal center and antibody response following vaccination in mice and ...
Denton, Alice E, Linterman, Michelle A
core   +1 more source

Investigating the Mechanism of Germinal Center Shutdown

Frontiers in Immunology, 2022
Germinal centers (GCs) are transient structures where affinity maturation of B cells gives rise to high affinity plasma and memory cells. The mechanism of GC shutdown is unclear, despite being an important phenomenon maintaining immune homeostasis.
Theinmozhi Arulraj, Sebastian C. Binder, Michael Meyer-Hermann, Michael Meyer-Hermann   +3 more
doaj   +1 more source

Novel specialized cell state and spatial compartments within the germinal center

Nature Immunology, 2020
Within germinal centers (GCs), complex and highly orchestrated molecular programs must balance proliferation, somatic hypermutation and selection to both provide effective humoral immunity and to protect against genomic instability and neoplastic ...
Domenick E. Kennedy, Michael K. Okoreeh, M. Maienschein-Cline, Junting Ai, M. Veselits, Kaitlin C. McLean, Yogesh Dhungana, Hong Wang, Junmin Peng, Hongbo Chi, M. Mandal, M. Clark   +11 more
semanticscholar   +1 more source

Type I interferon induces CXCL13 to support ectopic germinal center formation

Journal of Experimental Medicine, 2019
Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection, this response can be beneficial for the host: influenza A virus infection–induced pulmonary ...
A. Denton, S. Innocentin, E. J. Carr, Barry M. Bradford, Fanny Lafouresse, N. Mabbott, U. Mörbe, B. Ludewig, J. Groom, K. Good-Jacobson, M. Linterman   +10 more
semanticscholar   +1 more source

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients

Current Medical Science, 2020
The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease.
Y. Duan, M. Xia, L. Ren, Yan-fang Zhang, Q. Ao, San-peng Xu, D. Kuang, Qian Liu, Bing Yan, Yi-wu Zhou, Q. Chu, Liang Liu, Xiang-Ping Yang, Guo-ping Wang   +13 more
semanticscholar   +1 more source