Results 71 to 80 of about 4,224,412 (338)

B cell-intrinsic interleukin 17 receptor A signaling supports the establishment of chronic murine gammaherpesvirus 68 infection

Journal of Virology
The human-specific gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus infect >95% of all adults, establish lifelong infections, and are associated with multiple different cancers, including B-cell lymphomas.
Sheikh Tahir Majeed, Nicholas P. Huss, Samantha M. Bradford, Christopher N. Jondle   +3 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Journal of Experimental Medicine, 2018
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory.
N. Pardi, Michael J. Hogan, Martin S Naradikian, Kaela Parkhouse, D. Cain, Letitia Jones, M. A. Moody, H. Verkerke, A. Myles, Elinor Willis, C. Labranche, D. Montefiori, Jenna L. Lobby, K. Saunders, H. Liao, B. Korber, Laura L. Sutherland, R. Scearce, P. Hraber, I. Tombácz, Hiromi Muramatsu, Houping Ni, D. A. Balikov, Charles Li, B. Mui, Ying K. Tam, F. Krammer, K. Karikó, P. Polacino, L. Eisenlohr, T. D. Madden, M. Hope, M. Lewis, Kelly K. Lee, Shiu-Lok Hu, S. Hensley, M. Cancro, B. Haynes, D. Weissman   +38 more
semanticscholar   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source

B cell-intrinsic IRF-1 and conserved gammaherpesvirus protein kinase cooperate to promote murine gammaherpesvirus-driven germinal center response and splenic latent reservoir

Journal of Virology
Gammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells ...
Cade R. Rahlf, Christopher N. Jondle, Erika R. Johansen, Vera L. Tarakanova   +3 more
doaj   +1 more source

Germinal center‐derived lymphomas: The darkest side of humoral immunity

Immunological Reviews, 2019
One of the unusual features of germinal center (GC) B cells is that they manifest many hallmarks of cancer cells. Accordingly, most B‐cell neoplasms originate from the GC reaction, and characteristically display abundant point mutations, structural ...
Coraline Mlynarczyk, L. Fontán, A. Melnick   +2 more
semanticscholar   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

Expression of H2bYFP does not alter germinal center dynamics of MHV68-H2bYFP. [PDF]

, 2013
Mice were infected with 1,000 pfu of the indicated virus and spleens were harvested at the indicated day post-infection. A) Total germinal center B cell analysis.
Samuel H. Speck (70359), Christopher M. Collins (309503)   +1 more
core   +1 more source

The germinal center antibody response in health and disease [version 1; referees: 2 approved]

F1000Research, 2016
The germinal center response is the delayed but sustained phase of the antibody response that is responsible for producing high-affinity antibodies of the IgG, IgA and/or IgE isotypes. B cells in the germinal center undergo re-iterative cycles of somatic
Anthony L. DeFranco
doaj   +1 more source

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

Cell, 2019
Summary Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses that are higher in magnitude and affinity than the primary response.
L. Mesin, Ariën Schiepers, Jonatan Ersching, Alexandru Barbulescu, Cecilia B. Cavazzoni, A. Angelini, T. Okada, T. Kurosaki, G. Victora   +8 more
semanticscholar   +1 more source