Results 81 to 90 of about 4,224,412 (338)

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Germinal Center Quality Control: Death by Fas [PDF]

, 2015
Fas is a cell surface death receptor critical for immune regulation. In this issue of Immunity, Butt et al. (2015) show that Fas eliminates B cells that have become uncoupled from positive and negative selection in the germinal ...
Allen, Christopher D.C.
core   +1 more source

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

Cell Reports, 2020
Summary: The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr)
Ine Vanderleyden, Sigrid C. Fra-Bido, Silvia Innocentin, Marisa Stebegg, Hanneke Okkenhaug, Nicola Evans-Bailey, Wim Pierson, Alice E. Denton, Michelle A. Linterman   +8 more
doaj   +1 more source

Immune metabolism regulation of the germinal center response

Experimental and Molecular Medicine, 2020
The humoral immune response requires germinal centers to produce high-affinity antigen-specific antibodies that counter pathogens. Numerous studies have provided a better understanding of how metabolic pathways regulate the development, activation and ...
Seung-Chul Choi, L. Morel
semanticscholar   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Germinal-Center B Cells in the Zone [PDF]

, 2007
Visualization of lymphocyte dynamics in vivo has only recently become feasible. In this issue of Immunity, Hauser et al.
Brink, Robert
core   +1 more source

B and T Cell Interplay, Germinal Center Dynamics and Role of Regulatory T Cells (Tregs) in B Cell Modulation and Immune Tolerance: A Narrative Review

Immuno
T cells and B cells are central components of the adaptive immune system, orchestrating immune responses through a complex network of interactions.
Mohammad Shahid Iqbal, Ahmad F. Arbaeen, M. A. Bendary, Hasan H. Qadi, Aisha Tabassum, Othman M. Fallatah, Sami Melebari, Nadeem Ikram, Mohammed Parvez, Kamal H. Alzabeedi   +9 more
doaj   +1 more source

Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors

Journal of Immunology Research, 2020
An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs).
Lei Huang, Jianning Deng, Ren Lang, Guoyang Liao, Wei Jiang   +4 more
doaj   +1 more source

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]

PLoS ONE, 2012
Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich, Tara Reisbig, David G Schatz   +2 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source