Results 101 to 110 of about 72,003 (345)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Caracterización biológica y pronóstica del linfoma difuso de células grandes en la era de la inmunoquimioterapia [PDF]

, 2011
El linfoma difuso de células grandes (LDCGB) es la neoplasia linfoide agresiva más frecuente en el mundo occidental. Sin embargo, es una entidad nosológica heterogénea de difícil caracterización por técnicas convencionales.
Gutiérrez García, Gonzalo
core  

Germinal Center Quality Control: Death by Fas

, 2015
Fas is a cell surface death receptor critical for immune regulation. In this issue of Immunity, Butt et al. (2015) show that Fas eliminates B cells that have become uncoupled from positive and negative selection in the germinal ...
Allen, Christopher D.C.
core   +1 more source

CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.

PLoS ONE, 2016
SAP (SH2D1A) is required intrinsically in CD4 T cells to generate germinal center responses and long-term humoral immunity. SAP binds to SLAM family receptors, including SLAM, CD84, and Ly108 to enhance cytokine secretion and sustained T cell:B cell ...
Joyce K Hu, Jordan C Crampton, Michela Locci, Shane Crotty   +3 more
doaj   +1 more source

Latent Epstein-Barr virus infection and the germinal center reaction [PDF]

, 2007
Epstein-Barr virus (EBV) is a γ-herpes virus which preferentially infects human B lymphocytes. It is highly adapted to persist in B cells since it encodes for proteins which mimic several cellular proteins playing an important role in B cell ...
Rastelli, Julia, Rastelli, J.
core  

Germinal-Center B Cells in the Zone

, 2007
Visualization of lymphocyte dynamics in vivo has only recently become feasible. In this issue of Immunity, Hauser et al.
Brink, Robert
core   +1 more source

Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation [PDF]

, 2019
Summary: B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion
Buckley, Christopher, Aksoy, E., Anna Vossenkämper, Capasso, Melanie, Stopka-Farooqui, U., Urszula Stopka-Farooqui, John Gribben, Stopka-Farooqui, Urszula, Parsonage, Gregory, Parsonage, G., Oliver Haworth, Norris, S., Korbonits, Marta, Haworth, O, Haworth, O., Marshall, Jennifer; id_orcid, Gribben, J, Vossenkämper, A., Aksoy, E, Haworth, Oliver, Stopka-Farooqui, U, Parsonage, G, Buckley, CD, Vossenkamper, A, Gregory Parsonage, Clear, A., Capasso, M, Norris, S, Christopher D. Buckley, Xinyu Wan, Buckley, C., Andrew Clear, Gribben, J., Korbonits, M., Clear, Andrew, Gribben, John, Sherine Norris, Barry, Sayka, MacDonald, TT, Norris, Sherine, Jennifer L. Marshall, Thomas T. MacDonald, Marshall, J., Márta Korbonits, Wan, X, Sun, D, Sun, Dijue, Dijue Sun, Sun, D., MacDonald, T., Wan, X., Barry, S., Sayka Barry, Askoy, Ezra, MacDonald, Thomas T., Melania Capasso, Clear, A, Korbonits, M, Barry, S, Marshall, JL, Wan, Xinyu, Ezra Aksoy, Vossenkamper, Anna, Capasso, M.   +63 more
core   +1 more source

SIRs for non-germinal center neoplasms in autoimmune disease patients.

, 2016
SIRs for non-germinal center neoplasms in autoimmune disease patients.
Asta Försti (76997), Jianguang Ji (809356), Kari Hemminki (76996), Xiangdong Liu (79858)   +3 more
core   +1 more source

MYC-mediated transcriptional control of splicing factors promotes RNA splicing in activated B lymphocytes

Scientific Reports
Germinal center B cells play a pivotal role in the generation of long-lived plasma cells and high-affinity antibodies. Although RNA splicing and alternative splicing are known to regulate germinal center B cell responses, the upstream mechanisms ...
Silu Li, Chengyu Yang, Jiayuan Li, Zhenya Liu, Fenfang Gong, Xiaosu Ke, Gui-Xin Ruan, Hengjun Huang   +7 more
doaj   +1 more source

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

Cell Reports, 2017
Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate ...
Dana Piovesan, Jessica Tempany, Andrea Di Pietro, Inge Baas, Callisthenis Yiannis, Kristy O’Donnell, Yunshun Chen, Victor Peperzak, Gabrielle T. Belz, Charles R. Mackay, Gordon K. Smyth, Joanna R. Groom, David M. Tarlinton, Kim L. Good-Jacobson   +13 more
doaj   +1 more source