Results 121 to 130 of about 4,224,412 (338)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

PRMT5 is essential for B cell development and germinal center dynamics

Nature Communications, 2019
Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine protein ...
Ludivine C. Litzler, Astrid Zahn, Alexandre P. Meli, S. Hébert, A. Patenaude, Stephen P. Methot, Adrien Sprumont, Thérence Bois, D. Kitamura, S. Costantino, Irah L. King, C. Kleinman, S. Richard, J. D. Di Noia   +13 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The functions of transcription factors IRF8 and PU.1 in B cell activation and differentiation have been poorly understood due to redundancy between the family members.
Hongsheng Wang, Shweta Jain, Peng Li, Jian-Xin Lin, Jangsuk Oh, Chen-feng Qi, Yuanyuan Gao, Jiafang Sun, Tomomi Sakai, Z. Naghashfar, Sadia Abbasi, A. Kovalchuk, S. Bolland, S. Nutt, W. Leonard, H. Morse   +15 more
semanticscholar   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

KLHL6 Is Preferentially Expressed in Germinal Center–Derived B-Cell Lymphomas [PDF]

, 2017
KLHL6 is a recently described BTB-Kelch protein with selective expression in lymphoid tissues and is most strongly expressed in germinal center B cells.
Tibshirani, Robert John, Sabile, Jean M, Alizadeh, Ash A, Gualco, Gabriela, Ranjana H Advani, Gabriela Gualco, Lossos, Izidore S, Yasodha Natkunam, Roncador, Giovanna, Advani, Ranjana H, Christian A Kunder, Ash A Alizadeh, Carlos E Bacchi, Kunder, Christian A, Bacchi, Carlos E, Kexin Nie, Robert John Tibshirani, Natkunam, Yasodha, Giovanna Roncador, Michael R Green, Nie, Kexin, Jean M Sabile, Green, Michael R, Izidore S Lossos   +23 more
core   +1 more source

Tinigible Body Macrophages in Regulation of Germinal Center Reactions [PDF]

, 1998
Tingible body macrophages (TBM), long thought simply as scavengers of apoptotic lymphocytes, are located in the unique microenvironment of germinal centers in close proximity to antigen-retaining follicular dendritic cells (FDC).
NC DOCKS at East Carolina University
core   +6 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection.

PLoS Pathogens
Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity.
Linda M Sircy, Andrew G Ramstead, Lisa C Gibbs, Hemant Joshi, Andrew Baessler, Ignacio Mena, Adolfo García-Sastre, Lyska L Emerson, Keke C Fairfax, Matthew A Williams, J Scott Hale   +10 more
doaj   +1 more source

CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.

PLoS ONE, 2016
SAP (SH2D1A) is required intrinsically in CD4 T cells to generate germinal center responses and long-term humoral immunity. SAP binds to SLAM family receptors, including SLAM, CD84, and Ly108 to enhance cytokine secretion and sustained T cell:B cell ...
Joyce K Hu, Jordan C Crampton, Michela Locci, Shane Crotty   +3 more
doaj   +1 more source