Results 141 to 150 of about 4,224,412 (338)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation [PDF]
, 2019 Summary: B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion
Buckley, Christopher +63 more
core +1 more source
Defects in germinal center selection in SLE
Frontiers in Immunology, 2015 Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occurs. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and ...
Megan eWoods +2 more
doaj +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Haematologica, 2009 Background Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data.
Heinz-Wolfram Bernd +19 more
doaj +1 more source
The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center
Science, 2017 Light- and dark-zone death dynamics Germinal centers (GCs) are areas within lymphoid organs where mature B cells expand and differentiate during normal immune responses.
C. Mayer +12 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Role of acetyl-CoA metabolism in B cell germinal center reaction [PDF]
, 2023 reservedB cell development is characterized by both metabolic and epigenetic reprogramming. Notably, metabolic inputs can be integrated into the epigenome to inform cell fate decisions in physiological and pathological contexts. Nevertheless, it is still
BALASSO, VALENTINA
core
Science immunology, 2017 A distinct population of B cells that respond to vaccination serve as potential plasma cell precursors. Plasma cell precursors Memory B cells are critical players in the rapid secondary immune response to pathogens; however, little is known about B cell ...
D. Lau +12 more
semanticscholar +1 more source