Molecular pathogenesis of germinal center‐derived B cell lymphomas
Immunological Reviews, 2019 B cell lymphomas comprise a heterogeneous group of genetically, biologically, and clinically distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the germinal center (GC). In recent years, the advent of novel genomics
L. Pasqualucci
semanticscholar +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Caracterización biológica y pronóstica del linfoma difuso de células grandes en la era de la inmunoquimioterapia [PDF]
, 2011 El linfoma difuso de células grandes (LDCGB) es la neoplasia linfoide agresiva más frecuente en el mundo occidental. Sin embargo, es una entidad nosológica heterogénea de difícil caracterización por técnicas convencionales.
Gutiérrez García, Gonzalo
core
Germinal centers and the B-cell system: VI. Migration pattern of germinal-center cells of the rabbit appendix [PDF]
, 1981 The migration pattern of germinal center cells of the rabbit appendix was studied and compared with that of appendix dome cells, spleen cells, thymus cells and thoracic duct lymphocytes.
Nieuwenhuis, Paul +9 more
core +1 more source
Induced Germinal Center B Cell Culture System
Bio-Protocol, 2019 The germinal center (GC) is the site where B cells undergo clonal expansion, affinity-based selection, and differentiation into memory B cells or plasma cells.
Kei Haniuda, Daisuke Kitamura
doaj +1 more source
Linking Signaling and Selection in the Germinal Center
Immunological Reviews, 2019 Germinal centers (GC) are sites of rapid B‐cell proliferation in response to certain types of immunization. They arise in about 1 week and can persist for several months. In GCs, B cells differentiate in a unique way and begin to undergo somatic mutation
M. Shlomchik, W. Luo, Florian J. Weisel
semanticscholar +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Latent Epstein-Barr virus infection and the germinal center reaction [PDF]
, 2007 Epstein-Barr virus (EBV) is a γ-herpes virus which preferentially infects human B lymphocytes. It is highly adapted to persist in B cells since it encodes for proteins which mimic several cellular proteins playing an important role in B cell ...
Rastelli, Julia, Rastelli, J.
core
HGAL Protein Expression Persists in Disorders of Germinal Center Dissolution [PDF]
, 2011 Human Germinal Center-associated Lymphoma (HGAL) is a germinal center (GC) B-cell marker associated with a favorable outcome in diffuse large B-cell and classic Hodgkin lymphomas (CHL).
Shuchun Zhao +7 more
core +1 more source
Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways [PDF]
, 2011 Multiple distinct memory B-cell subsets have been identified in humans, but it remains unclear how their phenotypic diversity corresponds to the type of responses from which they originate.
Bikos, V. (Vasilis) +11 more
core +3 more sources