Results 151 to 160 of about 72,003 (345)

Distinct metabolic requirements regulate B cell activation and germinal center responses [PDF]

, 2023
Rahul Sharma, Ryan Smolkin, Priyanka Chowdhury, Keith Conrad Fernandez, Youngjun Kim, Montserrat Cols, William Alread, Wei-Feng Yen, Wei Hu, Zhong-Min Wang, Sara Violante, Ronan Chaligné, Ming O. Li, Justin R. Cross, Jayanta Chaudhuri   +14 more
openalex   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The role of CCRL2 in the regulation of germinal centre B-cell migration and a new regulatory step in T-cell migration into tissue during inflammation; separating the wanted from the unwanted

, 2011
CC-Chemokine receptor like 2 (CCRL2) is the newest member of the atypical chemokine receptor family, a set of proteins which tend to act as “decoy receptors”, causing a chemoattractant gradient of their ligands.
Cook, Sarah Louise
core  

IgM from BALB/c mice enhances germinal center responses.

, 2013
On day 0, BALB/c mice were immunized i.v. with WT or Cµ13 IgM specific for KLH (50 µg/mouse) or SRBC (0.2 ml of a solution with HA titer 1:32) 30 min before 10 µg KLH (A), 5×105 (B) or 5×106 SRBC (C) were administered via the same route; controls ...
Birgitta Heyman (314431), Zhoujie Ding (348777), Rika Ouchida (481594), Hiroshi Ohno (266170), Anna Bergman (314427), Ji-Yang Wang (481595), Christian Rutemark (314426)   +6 more
core   +1 more source

Additional file 1: of Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response

, 2016
Elizabeth Ernestina Godoy-Lozano, Juan Mauricio Téllez-Sosa, Gilberto Sánchez-González, Hugo Sámano-Sánchez, Andrés Aguilar-Salgado, Aarón Salinas-Rodríguez, Bernardo Cortina-Ceballos, Héctor Vivanco-Cid, Karina Guadalupe Hernández-Flores, Jennifer M. Pfaff, Kristen M. Kahle, Benjamin Doranz, Rosa Elena Gómez-Barreto, Humberto Valdovinos-Torres, Irma Elena López-Martínez, Mario Rodriguez, Jesús Martínez-Barnetche   +16 more
openalex   +1 more source

Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction [PDF]

, 2018
Xin Li, Adeline Gadzinsky, Liying Gong, Haijun Tong, Virginie Calderon, Yue Li, Daisuke Kitamura, Ulf Klein, Wallace Y. Langdon, Fajian Hou, Yong-Rui Zou, Hua Gu   +11 more
openalex   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis [PDF]

, 2017
Elisa Ferretti, Emma Di Carlo, Emanuela Ognio, Giulio Fraternali Orcioni, Anna Corcione, Beatrice Belmonte, Jean Louis Ravetti, Claudio Tripodo, Doménico Ribatti, Vito Pistoia   +9 more
openalex   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source