Results 151 to 160 of about 63,576 (258)

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Inference of germinal center evolutionary dynamics via simulation-based deep learning. [PDF]

Elife
Ralph DK, Bakis AG, Galloway JG, Vora AA, Araki T, Victora GD, Song YS, DeWitt WS, Matsen FA.   +8 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Germinal Center-Like Tertiary Lymphoid Structures Mark Immune Responsiveness and Enable Checkpoint Immunotherapy in Bladder Cancer. [PDF]

Oncol Res
Yin Z, Zhen X, Li H, Duan H, Hu X, Yu T, Shi Q, Liu Z, Li Y, Zhang P, Dai P, Zhao M, Wang Z, Li C, Wang D, Tong Z.   +15 more
europepmc   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Gap-Junction Communication Pathways in Germinal Center Reactions

Clinical and Developmental Immunology, 1998
Tibor Krenacs, Martin Rosendaal
doaj   +1 more source

CD9⁺ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression. [PDF]

Adv Sci (Weinh)
Liao W, Song L, Xu M, Liang T, Chen Y, Chen G, Lin Z, Du H, Feng G, Feng Z, Zhang Q, Pan F, Yang S, Zhang X, Peng W, Li T, Lin Z, Chen Y, Liu J, Peng B, Liu Y, Niu X, Li T, Huang C, Mo K, Xie J, Zou Y, Zhang X.   +27 more
europepmc   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

A tonsil organoid model reveals Epstein-Barr virus-infected germinal center B cell states during primary infection. [PDF]

Proc Natl Acad Sci U S A
Mitul MT, Sun Y, Yates TB, Sureshchandra S, Kastenschmidt JM, Sorn AM, Wagoner ZW, Joloya EM, Nair AK, Daugherty A, Saligrama N, Ahuja G, Zhong Q, Trask D, Forney C, Guo R, Weirauch MT, Kottyan LC, Gewurz BE, Wagar LE.   +19 more
europepmc   +1 more source