Results 151 to 160 of about 4,224,412 (338)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Stochastic discrete event simulation of germinal center reactions [PDF]
, 2005 We introduce a generic reaction-diffusion model for germinal center reactions and perform numerical simulations within a stochastic discrete event approach.
Figge, MT, Marc Thilo Figge
core +1 more source
Cell Reports, 2017 Summary: Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate ...
Dana Piovesan +13 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Scientific ReportsGerminal center B cells play a pivotal role in the generation of long-lived plasma cells and high-affinity antibodies. Although RNA splicing and alternative splicing are known to regulate germinal center B cell responses, the upstream mechanisms ...
Silu Li +7 more
doaj +1 more source
GERMINAL CENTER B CELL DYNAMICS
Immunity, 2016 Germinal centers (GCs) are the site of antibody diversification and affinity maturation, and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that ...
L. Mesin, Jonatan Ersching, G. Victora
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of CCRL2 in the regulation of germinal centre B-cell migration and a new regulatory step in T-cell migration into tissue during inflammation; separating the wanted from the unwanted [PDF]
, 2011 CC-Chemokine receptor like 2 (CCRL2) is the newest member of the atypical chemokine receptor family, a set of proteins which tend to act as “decoy receptors”, causing a chemoattractant gradient of their ligands.
Cook, Sarah Louise
core
IgM from BALB/c mice enhances germinal center responses. [PDF]
, 2013 On day 0, BALB/c mice were immunized i.v. with WT or Cµ13 IgM specific for KLH (50 µg/mouse) or SRBC (0.2 ml of a solution with HA titer 1:32) 30 min before 10 µg KLH (A), 5×105 (B) or 5×106 SRBC (C) were administered via the same route; controls ...
Birgitta Heyman (314431) +6 more
core +1 more source
B cell responses to a peptide epitope. VII. Antigen-dependent modulation of the germinal center reaction [PDF]
, 1998 Germinal center responses to two analogous peptides, PS1CT3 and G32CT3, that differ in sequence only at one position within the B cell epitopic region were examined.
Agarwal, Anshu +2 more
core +2 more sources