Results 111 to 120 of about 72,003 (345)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Spontaneous germinal center responses in BXD2 mice.
, 2015 (A) Auto-reactive autoantibody levels against double-strand DNA and histone in the sera of WT and BXD2 mice at the age of 6 months or older were measured by ELISA.
Young Uk Kim (110783) +4 more
core +1 more source
CXCR5+ CD8 T Cells: Protective or Pathogenic?
Frontiers in Immunology, 2019 CD8 T cells are infrequently considered part of germinal center reactions. Yet, a distinct CXCR5+ CD8 T cell subset identified within the B cell follicle and germinal center in situations of chronic antigen has recently been defined.
Kristen M. Valentine, Katrina K. Hoyer
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Modelling the affinity maturation of B lymphocytes in the germinal centre
, 2010 This study involved the successful development of a computer model to simulate the affinity maturation of B lymphocytes in the germinal centre in 3-D because certain behavioural aspects cannot currently be examined experimentally.
Reynolds, Adam Thomas
core
Functional anatomy of germinal centers
, 1984 This year we celebrate the first centennial of the discovery of germinal centers by Flemming in 1884. The present paper reviews and adds new data to the functional anatomy of a germinal center.
Nieuwenhuis, P. +5 more
core +1 more source
Epigenetic suppression of SLFN11 in germinal center B cells in the process of the dynamic expression change during B-cell development [PDF]
, 2020 Fumiya Moribe +7 more
openalex +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
A novel allele for inducible Cre expression in germinal center B cells
, 2019 The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP-mediated conditional gene knock-out or knock-in can be used for the genetic manipulation of germinal center B cells in vivo.
Weber, T. +11 more
core +1 more source