Results 31 to 40 of about 4,224,412 (338)

Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells

Viruses, 2022
Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo.
Shota Tsukimoto, Yoshiyuki Hakata, Sachiyo Tsuji-Kawahara, Takuji Enya, Tetsuo Tsukamoto, Seiya Mizuno, Satoru Takahashi, Shinichi Nakao, Masaaki Miyazawa   +8 more
doaj   +1 more source

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Nature Immunology, 2020
Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood.
Florian J. Weisel, S. Mullett, Rebecca A. Elsner, Ashley V Menk, Nikita H Trivedi, W. Luo, Daniel J. Wikenheiser, W. Hawse, M. Chikina, S. Smita, Laura Conter, Stephen M. Joachim, S. Wendell, M. Jurczak, T. Winkler, Greg M. Delgoffe, M. Shlomchik   +16 more
semanticscholar   +1 more source

Deriving a germinal center lymphocyte migration model from two-photon data [PDF]

, 2008
Recently, two-photon imaging has allowed intravital tracking of lymphocyte migration and cellular interactions during germinal center (GC) reactions. The implications of two-photon measurements obtained by several investigators are currently the subject ...
Michael Meyer-Hermann, Garin, A, Marie Kosco-Vilbois, Figge, MT, Figge, Marc Thilo, Marc Thilo Figge, Meyer-Hermann, M, Kosco-Vilbois, M, Kosco-Vilbois, Marie, Gunzer, Matthias, Garin, Alexandre, Kai-Michael Toellner, Meyer-Hermann, Michael (Prof. Dr.), Alexandre Garin, Gunzer, M, Matthias Gunzer, Toellner, Kai-Michael   +16 more
core   +1 more source

Th17 effector cells support B bell responses outside of germinal centres [PDF]

, 2012
Th17 cells are pro-inflammatory CD4+T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes.
David R Withers, Brewer James M., Benson, RA, David R. Withers, Paola Conigliaro, Agapitos Patakas (120270), Benson, R.A., Iain B McInnes, Patakas, A, David R. Withers (120281), Paul Garside, McInnes Iain B., Paul Garside (21184), Conigliaro, P, Withers, DR, Robert A. Benson, McInnes, I.B., CONIGLIARO, PAOLA, Patakas Agapitos, Benson Robert A., Patakas, A., Conigliaro, P., Withers David R., Agapitos Patakas, Brewer, J.M., Iain B. McInnes (120290), Robert A Benson, Paola Conigliaro (71046), Conigliaro Paola, Garside Paul, Robert A. Benson (120275), Garside, P, Mcinnes, LB, Garside, P., James M. Brewer, Iain B. McInnes, James M Brewer, Withers, D.R., Brewer, JM, James M. Brewer (120295)   +39 more
core   +1 more source

Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers. [PDF]

PLoS ONE, 2013
Lymphoid tissue immunopathology is a characteristic feature of chronic HIV/SIV infection in AIDS-susceptible species, but is absent in SIV-infected natural hosts.
Amanda J Martinot, Mareike Meythaler, Lu-Ann Pozzi, Karen Dalecki Boisvert, Heather Knight, Dennis Walsh, Susan Westmoreland, Daniel C Anderson, Amitinder Kaur, Shawn P O'Neil   +9 more
doaj   +1 more source

Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Haematologica, 2014
Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression ...
Xin Jiang, Honggang Guo, Jianguo Wu, Qiang He, Yiqiao Li, Miao Wang, Hongyang Pan, Wande Li, Jinjie Wang, Qingqing Wang, Jing Shen, Yuehai Ke, Ren Zhou   +12 more
doaj   +1 more source

Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis [PDF]

, 2008
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H ...
Tiacci, Enrico, Andreas Bräuninger, Ines Pfeil, Susan Eckerle, Ralf Küppers, Martin-Leo Hansmann, Doering, Claudia, Anja von Heydebreck, Küppers, Ralf, Brune, Verena, Bräuninger, Andreas, von Heydebreck, Anja, Enrico Tiacci, Hansmann, Martin-Leo, Verena Brune, van Noesel, Carel J. M., Klapper, Wolfram, Falini, Brunangelo, Heydebreck, Anja von, Braeuninger, Andreas, Pfeil, Ines, Brunangelo Falini, Wolfram Klapper, Claudia Döring, Metzler, Dirk, Eckerle, Susan, Döring, Claudia, Kueppers, Ralf, Carel J.M. van Noesel, Dirk Metzler   +29 more
core   +1 more source

Exosomes take (germinal) center stage [PDF]

, 2020
Efficient antibody production is a crucial step during immune responses leading to pathogen clearance and neutralization. Immune synapses, contact points between T and B lymphocytes in the presence of an antigen, are necessary to initiate the ...
Jennifer Pérez‐Boza, Pegtel, Dirk M., Dirk M Pegtel, Pérez-Boza, Jennifer   +3 more
core   +1 more source

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source

Textbook Germinal Centers? [PDF]

The Journal of Immunology, 2004
Abstract Models for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny. Indeed, recent studies have called several of
openaire   +2 more sources