Results 31 to 40 of about 4,714,009 (283)

Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis [PDF]

, 2008
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H ...
Tiacci, Enrico, Andreas Bräuninger, Ines Pfeil, Susan Eckerle, Ralf Küppers, Martin-Leo Hansmann, Doering, Claudia, Anja von Heydebreck, Küppers, Ralf, Brune, Verena, Bräuninger, Andreas, von Heydebreck, Anja, Enrico Tiacci, Hansmann, Martin-Leo, Verena Brune, van Noesel, Carel J. M., Klapper, Wolfram, Falini, Brunangelo, Heydebreck, Anja von, Braeuninger, Andreas, Pfeil, Ines, Brunangelo Falini, Wolfram Klapper, Claudia Döring, Metzler, Dirk, Eckerle, Susan, Döring, Claudia, Kueppers, Ralf, Carel J.M. van Noesel, Dirk Metzler   +29 more
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Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]

, 2000
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ, Rajko Reljic (406091), Rajko Reljic, Reljic, R, Fearon, DT, Simon D. Wagner, Luke J. Peakman, Luke J. Peakman (7768292), Fearon, D T, Douglas T. Fearon, Wagner, S D, Wagner, SD, Simon D. Wagner (7633943), Douglas T. Fearon (7768295), Peakman, L J   +14 more
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Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source

Textbook Germinal Centers? [PDF]

The Journal of Immunology, 2004
Abstract Models for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny. Indeed, recent studies have called several of
openaire   +2 more sources

Chemokine microenvironment in primary central nervous system lymphoma [PDF]

, 2010
Primary central nervous system lymphomas (PCNSL) are aggressive extranodal malignancies confined to the central nervous system (CNS), mostly of diffuse large B cell histotype.
Venetz, Daniel
core   +1 more source

Caracterización biológica y pronóstica del linfoma difuso de células grandes en la era de la inmunoquimioterapia [PDF]

, 2011
El linfoma difuso de células grandes (LDCGB) es la neoplasia linfoide agresiva más frecuente en el mundo occidental. Sin embargo, es una entidad nosológica heterogénea de difícil caracterización por técnicas convencionales.
Gutiérrez García, Gonzalo
core   +6 more sources

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

The Journal of Clinical Investigation, 2022
The synthesis of serine from glucose is a key metabolic pathway supporting cellular proliferation in healthy and malignant cells. Despite this, the role that this aspect of metabolism plays in germinal center biology and pathology is not known.
Annalisa D’Avola, Nathalie Legrave, Mylène Tajan, Probir Chakravarty, Ryan L. Shearer, Hamish W. King, Katarina Kluckova, Eric C. Cheung, Andrew J. Clear, Arief S. Gunawan, Lingling Zhang, Louisa K. James, James I. MacRae, John G. Gribben, Dinis P. Calado, Karen H. Vousden, John C. Riches   +16 more
doaj   +1 more source

Correlation between Germinal Center Differentiation and Double/Triple Hit Score in the Classification of Diffuse Large B Cell Non-Hodgkin Lymphoma: A Clinicopathological Approach

Asian Pacific Journal of Cancer Care, 2023
Background: Diffuse large B cell lymphoma (DLBCL) is considered the most common type of non-Hodgkin lymphoma. The global incidence of DLBCL has been doubled in the past decades, highlighting the need for more effective treatment regimens.
Israa Sobhy Abdel Razek Okap, Hanan Yehia Ahmed Tayel, Amany Abd El-Bary Abd El-Latif, Dalia Ahmed Mohamed Nafea, Nagwa Abdel Razek Mashali   +4 more
doaj   +1 more source

PENGARUH PEMBERIAN EPINEPRIN DAN HIDROKORTISON TERHADAP JUMLAH DAN DIAMETER GERMINAL CENTER KELENJAR GETAH BENING TIKUS PUTIH JANTAN WISTAR

Jurnal Berita Ilmu Keperawatan, 2008
Stress is a non specific respone of body if the deman of body increase cause a stressor. Stress will increase sympathetic activity with releasing apinephrine and cortisol.
Siti Arifah, Okti Sri Purwanti
doaj   +1 more source