Results 11 to 20 of about 4,224,412 (338)
YY1 Is Required for Germinal Center B Cell Development. [PDF]
PLoS ONE, 2016 YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including
Anupam Banerjee +6 more
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Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses [PDF]
Frontiers in Immunology, 2019 The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Theinmozhi Arulraj +6 more
doaj +2 more sources
SnapShot: The Germinal Center Reaction [PDF]
Cell, 2014 To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
Victora, Gabriel D.
openaire +3 more sources
Germinal centers and autoantibodies [PDF]
Immunology & Cell Biology, 2020 AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive ...
Clara, Young, Robert, Brink
openaire +2 more sources
Cells, 2021 Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells.
Theinmozhi Arulraj +2 more
doaj +1 more source
Cell, 2022 During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or
K. Röltgen +42 more
semanticscholar +1 more source
bioRxiv, 2023 Clarke and colleagues show that germinal center B cells have highly dynamic mitochondria, which are regulated by the transcription factor TFAM. TFAM activity is required to promote spatial entry into the germinal center reaction by modulating cellular ...
Yavuz F. Yazicioglu +7 more
semanticscholar +1 more source
Distinct metabolic requirements regulate B cell activation and germinal center responses
Nature Immunology, 2023 Sharma et al. identify an early metabolic checkpoint dependent upon lactate dehydrogenase for newly activated B cells to enter germinal centers. Following infection or vaccination, activated B cells at extrafollicular sites or within germinal centers ...
Rahul Sharma +14 more
semanticscholar +1 more source
The unique biology of germinal center B cells.
Immunity, 2021 Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies required for protective immunity. The unique biology of GC B cells involves iterative rounds of antibody gene somatic hypermutation coupled to multiple selection ...
Clara Young, R. Brink
semanticscholar +1 more source