Results 11 to 20 of about 72,003 (345)
YY1 Is Required for Germinal Center B Cell Development. [PDF]
PLoS ONE, 2016 YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including
Anupam Banerjee +6 more
doaj +3 more sources
Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses
Frontiers in Immunology, 2019 The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Theinmozhi Arulraj +6 more
doaj +2 more sources
Germinal Center Optimization Algorithm [PDF]
International Journal of Computational Intelligence Systems, 2018 Artificial immune systems are metaheuristic algorithms that mimic the adaptive capabilities of the immune system of vertebrates. Since the 1990s, they have become one of the main branches of computer intelligence.
Carlos Villaseñor +4 more
doaj +2 more sources
Regulation of the Germinal Center Response [PDF]
Frontiers in Immunology, 2018 The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
Marisa Stebegg +8 more
doaj +3 more sources
Cytokines in the Germinal Center Niche [PDF]
Antibodies, 2016 Cytokines are small, secreted, glycoproteins that specifically affect the interactions and communications between cells. Cytokines are produced transiently and locally, acting in a paracrine or autocrine manner, and they are extremely potent, ligating ...
Christoph Jandl, Cecile King
doaj +4 more sources
B cell-intrinsic IRF-1 and conserved gammaherpesvirus protein kinase cooperate to promote murine gammaherpesvirus-driven germinal center response and splenic latent reservoir [PDF]
Journal of VirologyGammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells ...
Cade R. Rahlf +3 more
doaj +2 more sources
Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host [PDF]
Journal of VirologyLipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral infection has been less explored.
Damon L. Schmalzriedt +6 more
doaj +2 more sources
SnapShot: The Germinal Center Reaction
Cell, 2014 To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
Victora, Gabriel D.
openaire +3 more sources
Cells, 2021 Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells.
Theinmozhi Arulraj +2 more
doaj +1 more source
Germinal centers and autoantibodies [PDF]
Immunology & Cell Biology, 2020 AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive ...
Clara, Young, Robert, Brink
openaire +2 more sources