Results 21 to 30 of about 4,224,412 (338)
Continuous Germinal Center Invasion Contributes to the Diversity of the Immune Response
Cell, 2022 Summary Antibody responses are characterized by increasing affinity and diversity over time. Affinity maturation occurs in germinal centers by a mechanism that involves repeated cycles of somatic mutation and selection.
Thomas Hägglöf +13 more
semanticscholar +1 more source
Annual Review of Immunology, 2012 Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that this structure is the site of B cell clonal expansion, somatic hypermutation, and affinity-based selection, the combination of which results in the production of high-affinity ...
Gabriel D, Victora +1 more
openaire +4 more sources
Frontiers in Immunology, 2022 The development of a safe and effective vaccine against Yersinia pestis, the causative organism for plague disease, remains an important global health priority.
Darrell R. Galloway +8 more
doaj +1 more source
Antibody Mediated Intercommunication of Germinal Centers
Cells, 2022 Antibody diversification and selection of B cells occur in dynamic structures called germinal centers (GCs). Passively administered soluble antibodies regulate the GC response by masking the antigen displayed on follicular dendritic cells (FDCs).
Theinmozhi Arulraj +2 more
doaj +1 more source
Cell Reports Medicine, 2022 Summary Emergence from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been facilitated by the rollout of effective vaccines. Successful vaccines generate high-affinity plasma blasts and long-lived protective memory B cells.
W. Foster +16 more
semanticscholar +1 more source
Analysis of immunophenotypic features in hyaline vascular type Castleman disease
Diagnostic Pathology, 2023 Background Studies suggested that the immunophenotype of hyaline vascular type Castleman disease (HVCD) lacked characteristics, which was easy to be confused with other diseases. Methods From January 2010 to June 2022, 17 cases of HVCD were selected from
Yu Chang, Yu Ma, Chen Chang, Wensheng Li
doaj +1 more source
Oncoimmunology, 2021 Pancreatic ductal adenocarcinoma (PDAC) has traditionally been thought of as an immunologically quiescent tumor type presumably because of a relatively low tumor mutational burden (TMB) and poor responses to checkpoint blockade therapy.
Andrew J. Gunderson +19 more
semanticscholar +1 more source
Dynamic Regulation of Tfh Selection During the Germinal Center Reaction
Nature, 2021 The germinal centre is a dynamic microenvironment in which B cells that express high-affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting the numbers of T follicular helper cells1,2.
Julia Merkenschlager +12 more
semanticscholar +1 more source
Dynamic regulation of B cell Complement Signaling is Integral to Germinal Center Responses
Nature Immunology, 2021 Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and high-affinity B cell antigen receptors (BCRs) for pathogen clearance.
A. Čumpelik +10 more
semanticscholar +1 more source
Germinal Center and Extrafollicular B Cell Responses in vaccination, immunity and autoimmunity
Immunity, 2020 Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses. Canonical responses are composed of a short wave of unmutated plasma cells arising from EF sites, followed by GC producing somatically mutated memory B cells (
Rebecca A. Elsner, M. Shlomchik
semanticscholar +1 more source