Results 21 to 30 of about 26,681 (151)
Synaptic Interactions in Germinal Centers
Frontiers in Immunology, 2018 The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells.
Ilenia Papa, Carola G. Vinuesa
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Investigating the Mechanism of Germinal Center Shutdown
Frontiers in Immunology, 2022 Germinal centers (GCs) are transient structures where affinity maturation of B cells gives rise to high affinity plasma and memory cells. The mechanism of GC shutdown is unclear, despite being an important phenomenon maintaining immune homeostasis.
Theinmozhi Arulraj +3 more
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Positive Selection in the Light Zone of Germinal Centers
Frontiers in Immunology, 2021 Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination.
Rinako Nakagawa +2 more
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Textbook Germinal Centers? [PDF]
The Journal of Immunology, 2004 Abstract Models for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny. Indeed, recent studies have called several of
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mBio, 2020 Enhancing the generation of broadly reactive antibodies against influenza A virus (IAV) is a pertinent goal toward developing a universal IAV vaccine. While antibodies that bind conserved IAV epitopes have been identified in humans, antibodies specific ...
Rachael Keating +5 more
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Prediction of improvement after extended thymectomy in non-thymomatous myasthenia gravis patients.
PLoS ONE, 2020 BackgroundIt is popularly believed that myasthenia gravis (MG) patients show acetylcholine receptor antibody (AChRAb) production associated with the thymus (germinal centers, approximately 80%).
Mitsuteru Yoshida +7 more
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A Theory of Germinal Center B Cell Selection, Division, and Exit
Cell Reports, 2012 High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments.
Michael Meyer-Hermann +5 more
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Altered Germinal-Center Metabolism in B Cells in Autoimmunity
Metabolites, 2022 B lymphocytes play an important role in the pathophysiology of many autoimmune disorders by producing autoantibodies, secreting cytokines, and presenting antigens. B cells undergo extreme physiological changes as they develop and differentiate.
Ashton K. Shiraz +2 more
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A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells. [PDF]
PLoS ONE, 2018 A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented.
Vinod Krishna, Kurtis E Bachman
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Journal of Immunology Research, 2015 Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicular lymphomas B cells escape apoptosis while FDC develop
Hajnalka Rajnai +9 more
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