Results 21 to 30 of about 49,637 (286)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Arterial/aortic tertiary lymphoid organs (ATLOs), characterized by germinal centers, control local arterial immune responses. T follicular helper cells (Tfh), resident in germinal centers, regulate immunoglobulin production and germinal center
Satomi Kasashima +8 more
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Investigating the Mechanism of Germinal Center Shutdown
Frontiers in Immunology, 2022 Germinal centers (GCs) are transient structures where affinity maturation of B cells gives rise to high affinity plasma and memory cells. The mechanism of GC shutdown is unclear, despite being an important phenomenon maintaining immune homeostasis.
Theinmozhi Arulraj +3 more
doaj +1 more source
Expression of thyroglobulin on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma [PDF]
, 2009 Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma.
Akagi, Tadaatsu +8 more
core +1 more source
Positive Selection in the Light Zone of Germinal Centers
Frontiers in Immunology, 2021 Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination.
Rinako Nakagawa +2 more
doaj +1 more source
Germinal centers and autoantibodies [PDF]
Immunology & Cell Biology, 2020 AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive ...
Clara, Young, Robert, Brink
openaire +2 more sources
mBio, 2020 Enhancing the generation of broadly reactive antibodies against influenza A virus (IAV) is a pertinent goal toward developing a universal IAV vaccine. While antibodies that bind conserved IAV epitopes have been identified in humans, antibodies specific ...
Rachael Keating +5 more
doaj +1 more source
Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae) [PDF]
, 2018 Teleostei present great plasticity regarding sex change. During sex reversal, the whole gonadincluding the germinal epithelium undergoes significant changes, remodeling, and neoformation.However, there is no information on the changes that occur within ...
Antoneli, Fernanda +3 more
core +2 more sources
Textbook Germinal Centers? [PDF]
The Journal of Immunology, 2004 AbstractModels for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny.
openaire +2 more sources
Prediction of improvement after extended thymectomy in non-thymomatous myasthenia gravis patients.
PLoS ONE, 2020 BackgroundIt is popularly believed that myasthenia gravis (MG) patients show acetylcholine receptor antibody (AChRAb) production associated with the thymus (germinal centers, approximately 80%).
Mitsuteru Yoshida +7 more
doaj +1 more source
The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help [PDF]
, 2017 Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial.
Allen +52 more
core +2 more sources