Results 31 to 40 of about 49,637 (286)
A Theory of Germinal Center B Cell Selection, Division, and Exit
Cell Reports, 2012 High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments.
Michael Meyer-Hermann +5 more
doaj +1 more source
Altered Germinal-Center Metabolism in B Cells in Autoimmunity
Metabolites, 2022 B lymphocytes play an important role in the pathophysiology of many autoimmune disorders by producing autoantibodies, secreting cytokines, and presenting antigens. B cells undergo extreme physiological changes as they develop and differentiate.
Ashton K. Shiraz +2 more
doaj +1 more source
A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells. [PDF]
PLoS ONE, 2018 A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented.
Vinod Krishna, Kurtis E Bachman
doaj +1 more source
Antigen-presenting cells and antigen presentation in tertiary lymphoid organs [PDF]
, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Bedaj, Marija +3 more
core +1 more source
Journal of Immunology Research, 2015 Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicular lymphomas B cells escape apoptosis while FDC develop
Hajnalka Rajnai +9 more
doaj +1 more source
Affinity Selection in Germinal Centers: Cautionary Tales and New Opportunities
Cells, 2021 Our current quantitative knowledge of the kinetics of antibody-mediated immunity is partly based on idealized experiments throughout the last decades.
Jose Faro, Mario Castro
doaj +1 more source
MicroRNAs in B cell development and malignancy [PDF]
, 2012 MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and ...
Fernando, Thilini R. +2 more
core +4 more sources
γδ T cells affect IL-4 production and B-cell tolerance [PDF]
, 2014 γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun +22 more
core +1 more source
Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]
, 1998 Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Bosbach, R. +3 more
core +1 more source
Cell Reports, 2020 Summary: It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B cells influence the unfolding differentiation before germinal center (GC) formation.
Marcus James Robinson +6 more
doaj +1 more source