Results 51 to 60 of about 26,681 (151)

Next generation sequencing of the clonal IGH rearrangement detects ongoing mutations and interfollicular trafficking in in situ follicular neoplasia.

PLoS ONE, 2017
Follicular lymphoma (FL) is characterized genetically by a significant intraclonal diversity of rearranged immunoglobulin heavy chain (IGH) genes and a substantial cell migration activity (follicular trafficking).
Perikles Kosmidis, Irina Bonzheim, Claudia Dufke, Sema Colak, Thomas Hentrich, Christopher Schroeder, Peter Bauer, Patrick Adam, Falko Fend   +8 more
doaj   +1 more source

Castleman's disease in the head of the pancreas: report of a rare clinical entity and current perspective on diagnosis, treatment, and outcome

World Journal of Surgical Oncology, 2007
Background Castleman's disease of the pancreas is a very rare condition that may resemble more common disease entities as well as pancreatic cancer. Case presentation Here we report the case of a 58-year-old African American male with an incidentally ...
Ghosh Bimal C, Desoto-Lapaix Fidelina, Zenilman Michael E, Wieczorek Rosemary L, Wang Hongbei, Bowne Wilbur B   +5 more
doaj   +1 more source

Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome

Arthritis Research & Therapy, 2017
Background This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates the possible correlation of ...
Jing Wang, Yubing Wen, Mengyu Zhou, Xiaoxiao Shi, Lanping Jiang, Mingxi Li, Yang Yu, Xuemei Li, Xuewang Li, Wen Zhang, Andrew L. Lundquist, Limeng Chen   +11 more
doaj   +1 more source

Germinal Center B-cells

Autoimmunity, 2012
Within the B-cell follicle of secondary lymphoid organs, germinal center (GC) reactions produce high affinity antibody-secreting plasma cells (PCs) and memory B-cells necessary for the host's defense against invading pathogens. This process of GC formation is reliant on the activation of antigen-specific B-cells by T-cells capable of recognizing ...
Keith M, Hamel, Vladimir M, Liarski, Marcus R, Clark   +2 more
openaire   +2 more sources

Accelerated involution of germinal center in palatine tonsils in IgA nephropathy.

PLoS ONE
BackgroundAltered immunological responses in the palatine tonsils may be involved in the pathogenesis of IgA nephropathy (IgAN). The germinal center serves as the site for antigen-specific humoral immune responses in the palatine tonsils. Germinal center
Hiroyuki Ueda, Kensuke Joh, Yoshimi Ueda, Hirokazu Marumoto, Masahiro Okabe, Nao Isaka, Nobuo Tsuboi, Hiromi Kojima, Yoichi Miyazaki, Takashi Yokoo   +9 more
doaj   +1 more source

THYMOMA AND THYMIC GERMINAL CENTER

The Keio Journal of Medicine, 1971
1. Ten cases in which the attached thymic tissues were histologically investigated from 91 cases of thymomas were reviewed with brief description of the gross appearance, histological findings and clinical complications.2. Thymic germinal centers were found in 7 cases of which 5 cases were associated with myasthenia gravis.3.
openaire   +3 more sources

SnapShot: The Germinal Center Reaction

Cell, 2014
To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
openaire   +2 more sources

Protocol for rapid 5-plex 3D imaging and single-cell analysis of immune responses in whole murine lymph nodes

STAR Protocols
Summary: Lymph nodes orchestrate adaptive immune responses, with germinal centers enabling affinity maturation and plasma cell formation. Here, we present a protocol for rapid, high-resolution, multicolor 3D imaging of whole immunized mouse lymph nodes ...
Victoire Boulat, Alessandro Ciccarelli, Miu Shing Hung, Lingling Zhang, Anita Grigoriadis, Dinis Pedro Calado   +5 more
doaj   +1 more source

germinal center

Citation: 'germinal center' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13172 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

The Ubiquitin Ligase Itch Skews Light Zone Selection in Germinal Centers. [PDF]

J Immunol, 2023
Renshaw L, Kim P, Crici M, Fazelinia H, Spruce L, Oliver P, Moser E.   +6 more
europepmc   +1 more source