Results 71 to 80 of about 49,637 (286)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Autoimmunity, 2012 Within the B-cell follicle of secondary lymphoid organs, germinal center (GC) reactions produce high affinity antibody-secreting plasma cells (PCs) and memory B-cells necessary for the host's defense against invading pathogens. This process of GC formation is reliant on the activation of antigen-specific B-cells by T-cells capable of recognizing ...
Keith M, Hamel +2 more
openaire +2 more sources
Secretory IgA (SIgA): designed for antimicrobial defence
Frontiers in Immunology, 2013 Prevention of infections by vaccination remains a compelling goal to improve public health. Mucosal vaccines would make immunization procedures easier, be better suited for mass administration, and most efficiently induce immune exclusion -- a term ...
Per eBrandtzaeg
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
NGFR regulates stromal cell activation in germinal centers
Cell ReportsSummary: Nerve growth factor receptor (NGFR) is expressed by follicular dendritic cells (FDCs). However, the role of NGFR in the humoral response is not well defined.
Alberto Hernández-Barranco +18 more
doaj +1 more source
Antigen presentation by B cells enables epitope spreading across an MHC barrier
Nature Communications, 2023 Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE)
Cecilia Fahlquist-Hagert +22 more
doaj +1 more source
The Immunoglobulins of Cold-Blooded Vertebrates [PDF]
, 2014 Peer reviewedPublisher ...
Chen +22 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Molecular Systems Biology, 2010 Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of ...
Celine Lefebvre +15 more
doaj +1 more source
Morphological changes in lymph nodes and spleen upon EAE induction in C57BL/6 mic [PDF]
Archives of Biological Sciences, 2013 Myelin oligodendrocyte glycoprotein (MOG) is a protein widely used in the induction of experimental autoimmune encephalomyelitis (EAE) for studying human multiple sclerosis (MS).
Maslovarić Irina +4 more
doaj +1 more source