Results 11 to 20 of about 49,637 (286)

Germinal Centers [PDF]

Annual Review of Immunology, 2012
Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that this structure is the site of B cell clonal expansion, somatic hypermutation, and affinity-based selection, the combination of which results in the production of high-affinity ...
Gabriel D, Victora, Michel C, Nussenzweig   +1 more
exaly   +6 more sources

Synaptic Interactions in Germinal Centers [PDF]

Frontiers in Immunology, 2018
The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells.
Ilenia Papa, Carola G. Vinuesa
doaj   +4 more sources

Spontaneous germinal centers and autoimmunity [PDF]

Autoimmunity, 2017
Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response.
Phillip P. Domeier, Stephanie L. Schell, Ziaur S. M. Rahman   +2 more
doaj   +3 more sources

Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. [PDF]

Cell, 2023
de Carvalho RVH, Ersching J, Barbulescu A, Hobbs A, Castro TBR, Mesin L, Jacobsen JT, Phillips BK, Hoffmann HH, Parsa R, Canesso MCC, Nowosad CR, Feng A, Leist SR, Baric RS, Yang E, Utz PJ, Victora GD.   +17 more
europepmc   +2 more sources

Germinal centers output clonally diverse plasma cell populations expressing high- and low-affinity antibodies. [PDF]

Cell, 2023
Sprumont A, Rodrigues A, McGowan SJ, Bannard C, Bannard O.   +4 more
europepmc   +2 more sources

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source

Optimality of mutation and selection in germinal centers. [PDF]

PLoS Computational Biology, 2010
The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we
Jingshan Zhang, Eugene I Shakhnovich
doaj   +1 more source

CCCTC-binding factor locks premature IgH germline transcription and restrains class switch recombination [PDF]

, 2017
In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Marina-Zárate, Ester, Pérez-García, Arantxa, Ramiro, Almudena R.   +2 more
core   +6 more sources

Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses

Frontiers in Immunology, 2019
The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Theinmozhi Arulraj, Sebastian C. Binder, Sebastian C. Binder, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Michael Meyer-Hermann   +6 more
doaj   +1 more source

In Silico Analysis of the Longevity and Timeline of Individual Germinal Center Reactions in a Primary Immune Response

Cells, 2021
Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells.
Theinmozhi Arulraj, Sebastian C. Binder, Michael Meyer-Hermann   +2 more
doaj   +1 more source