Results 11 to 20 of about 26,681 (151)

Clonal replacement sustains long-lived germinal centers primed by respiratory viruses [PDF]

Cell, 2023
Gabriel Victora
exaly   +2 more sources

Germinal centers and autoantibodies [PDF]

Immunology & Cell Biology, 2020
AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive ...
Clara, Young, Robert, Brink
openaire   +2 more sources

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues

Frontiers in Immunology, 2022
DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers.
Doaa Waly, Aradana Muthupandian, Chia-Wei Fan, Harrison Anzinger, Brad G. Magor   +4 more
doaj   +1 more source

THE ROLE OF B LYMPHOCYTES AND PRESENCE OF GERMINAL CENTERS IN PATIENTS WITH LOCALIZED PROVOKED VULVODYNIA

İstanbul Tıp Fakültesi Dergisi, 2022
Objective: The aim of the study is to assess local immune activation through B lymphocytes density and the presence of germinal centers in the vestibular mucosa of patients with localized provoked vulvodynia (LPV).
İrem Demiral Keleş, Cenk Yaşa, Semen Önder, Ekrem Yavuz, Sıtkı Tuzlalı, Süleyman Engin Akhan   +5 more
doaj   +1 more source

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source

Optimality of mutation and selection in germinal centers. [PDF]

PLoS Computational Biology, 2010
The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we
Jingshan Zhang, Eugene I Shakhnovich
doaj   +1 more source

Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses

Frontiers in Immunology, 2019
The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Theinmozhi Arulraj, Sebastian C. Binder, Sebastian C. Binder, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Michael Meyer-Hermann   +6 more
doaj   +1 more source

In Silico Analysis of the Longevity and Timeline of Individual Germinal Center Reactions in a Primary Immune Response

Cells, 2021
Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells.
Theinmozhi Arulraj, Sebastian C. Binder, Michael Meyer-Hermann   +2 more
doaj   +1 more source

Disordered Balance of T‐Cell Subsets in Arterial Tertiary Lymphoid Organs in Immunoglobulin G4–Related Vascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Arterial/aortic tertiary lymphoid organs (ATLOs), characterized by germinal centers, control local arterial immune responses. T follicular helper cells (Tfh), resident in germinal centers, regulate immunoglobulin production and germinal center
Satomi Kasashima, Atsuhiro Kawashima, Nozomu Kurose, Satoru Ozaki, Fuminori Kasashima, Yasushi Matsumoto, Hirofumi Takemura, Hiroko Ikeda, Ken‐ichi Harada   +8 more
doaj   +1 more source