Results 21 to 30 of about 14,801,660 (264)

Follicular lymphoma regulatory T-cell origin and function

Frontiers in Immunology
IntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez, Mehdi Alizadeh, Claire Lamaison, Alexis Saintamand, Céline Monvoisin, Rachel Jean, Rachel Jean, Laurent Deleurme, Laurent Deleurme, Jose Ignacio Martin-Subero, Céline Pangault, Céline Pangault, Michel Cogné, Patricia Amé-Thomas, Patricia Amé-Thomas, Karin Tarte, Karin Tarte   +16 more
doaj   +4 more sources

Immunological dysregulation of follicular helper T cells, follicular regulatory T cells, and follicular cytotoxic T cells is associated with disease activity and identifies exploratory immune patterns in rheumatoid arthritis [PDF]

Frontiers in Immunology
BackgroundThe onset and progression of rheumatoid arthritis (RA) are linked to autoantibody production driven by dysregulated germinal center (GC) responses. Follicular helper T cells (Tfh), follicular regulatory T cells (Tfr), and follicular cytotoxic T
Yuxin Fan, Yuxin Fan, Yuxin Fan, Baochen Li, Baochen Li, Baochen Li, Ruihe Wu, Ruihe Wu, Ruihe Wu, Xiaoyang Liu, Xiaoyang Liu, Xiaoyang Liu, Xiaoyu Zi, Xiaoyu Zi, Xiaoyu Zi, Yuhuan Xie, Yuhuan Xie, Yuhuan Xie, Chong Gao, Caihong Wang, Caihong Wang, Caihong Wang   +21 more
doaj   +2 more sources

Imbalance of Circulatory T Follicular Helper and T Follicular Regulatory Cells in Patients with ANCA-Associated Vasculitis [PDF]

Mediators of Inflammation, 2019
Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is characterized by small-vessel inflammation in association with autoantibodies. Balance between T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells is critical
Ying Xu, Hongmei Xu, Yu Zhen, Xueting Sang, Hao Wu, Cong Hu, Zhanchuan Ma, Miaomiao Yu, Huanfa Yi   +8 more
doaj   +2 more sources

The role of regulatory T cells and follicular T helper cells in HBV infection

Frontiers in Immunology, 2023
Hepatitis B has become one of the major global health threats, especially in developing countries and regions. Hepatitis B virus infection greatly increases the risk for liver diseases such as cirrhosis and cancer.
Nengqi Lin, Wei Yin, Heather Miller, Maria G. Byazrova, Andrés A. Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu   +13 more
doaj   +3 more sources

T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]

, 2012
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F., James eAlexander, Frank Brombacher, Frank eBrombacher, Alexander, J., James Alexander   +5 more
core   +4 more sources

T follicular helper cells, T follicular regulatory cells and autoimmunity. [PDF]

Int Immunol, 2016
Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Zhu Y, Zou L, Liu YC.
europepmc   +4 more sources

T Follicular Regulatory Cells and Antibody Responses in Transplantation. [PDF]

Transplantation, 2018
Abstract De novo donor-specific antibody (DSA) formation is a major problem in transplantation, and associated with long-term graft decline and loss as well as sensitization, limiting future transplant options. Forming high-affinity, long-lived antibody responses involves a process called the germinal center (GC) reaction, and requires ...
Wallin EF.
europepmc   +4 more sources

T follicular regulatory cells: Guardians of the germinal centre? [PDF]

Scand J Immunol, 2020
AbstractIt is a central tenet of the clonal selection theory, that lymphocyte repertoires are tolerized to self‐antigens during their ontogeny. Germinal centres are the sites in secondary lymphoid tissues where B cells undergo affinity maturation and class‐switching to produce high‐affinity antibodies.
Fahlquist Hagert C, Degn SE.
europepmc   +5 more sources

Follicular regulatory T cell in atherosclerosis [PDF]

Journal of Leukocyte Biology, 2018
Abstract Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several ...
Baptista, Daniela, Mach, François, Brandt, Karim   +2 more
openaire   +4 more sources

The impact of molecular alterations and the immune microenvironment on the natural history of Follicular Lymphoma including transformation to Diffuse Large B cell Lymphoma [PDF]

, 2009
PhDThe natural history of follicular lymphoma is heterogeneous with numerous relapses and remissions over many years. A substantial number of patients suffer an aggressive disease course with death due to disease within 5 years of diagnosis.
Lee, Abigail Mary
core   +4 more sources