Results 21 to 30 of about 15,753,813 (238)

The epigenetic trajectory of type 1 regulatory T cells

eLife
The epigenome of T follicular helper cells prepares them for conversion into type 1 regulatory T cells.
David P Turicek, Xiaoxiao Wan
doaj   +2 more sources

T Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses. [PDF]

Front Immunol, 2021
Lu Y, Craft J.
europepmc   +2 more sources

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

Nature Communications, 2017
IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.
Christoph Jandl, Sue M. Liu, Pablo F. Cañete, Joanna Warren, William E. Hughes, Alexis Vogelzang, Kylie Webster, Maria E. Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King   +14 more
doaj   +2 more sources

Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

Cell Reports, 2019
Summary: Follicular regulatory T (TFR) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance.
Lei Wang, Erxia Shen, Lin Luo, Hardis Rabe, Qin Wang, Jie Yin, Xueying Yang, Wenquan Liu, Jessica M. Sido, Hidetoshi Nakagawa, Lin Ao, Hye-Jung Kim, Harvey Cantor, Jianmei W. Leavenworth   +13 more
doaj   +3 more sources

T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]

, 2012
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F., James eAlexander, Frank Brombacher, Frank eBrombacher, Alexander, J., James Alexander   +5 more
core   +4 more sources

T follicular helper cells, T follicular regulatory cells and autoimmunity. [PDF]

Int Immunol, 2016
Zhu Y, Zou L, Liu YC.
europepmc   +2 more sources

Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner

Frontiers in Immunology, 2022
Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton, Joy M. Folkvord, Andriana La Mantia, David A. Parry, Amie L. Meditz, Martin D. McCarter, Richard T. D’Aquila, Elizabeth Connick   +7 more
doaj   +1 more source

Highly sensitised individuals present a distinct Treg signature compared to unsensitised individuals on haemodialysis

Frontiers in Transplantation, 2023
IntroductionHighly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss.
C. Dudreuilh, C. Dudreuilh, S. Basu, S. Basu, O. Shaw, H. Burton, H. Burton, N. Mamode, N. Mamode, F. Harris, T. Tree, P. Nedyalko, M. Terranova-Barberio, G. Lombardi, C. Scottà, A. Dorling, A. Dorling   +16 more
doaj   +1 more source

Altered Distribution of Circulating T Follicular Helper-Like Cell Subsets in Rheumatoid Arthritis Patients

Frontiers in Medicine, 2021
Objective: Recent studies on follicular regulatory T (Tfr) and follicular helper T (Tfh) cells suggest that they may participate in the pathogenesis of rheumatoid arthritis (RA).
Rui Su, Yanyan Wang, Fangyuan Hu, Baochen Li, Qiaoling Guo, Xinyu Zheng, Yue Liu, Chong Gao, Xiaofeng Li, Caihong Wang   +9 more
doaj   +1 more source

Follicular Regulatory T Cells in Systemic Lupus Erythematosus

Journal of Immunology Research, 2021
Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses.
Xin Xia, Jun Yang, Shengjun Wang
doaj   +1 more source