Results 11 to 20 of about 58,285 (234)
T follicular helper cells, T follicular regulatory cells and autoimmunity. [PDF]
Int Immunol, 2016 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Zhu Y, Zou L, Liu YC.
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Follicular Regulatory T Cells in Systemic Lupus Erythematosus [PDF]
Journal of Immunology Research, 2021 Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses.
Xin Xia, Jun Yang, Shengjun Wang
doaj +3 more sources
Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells [PDF]
Frontiers in Immunology, 2019 The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving ...
Paul-Gydéon Ritvo +2 more
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Follicular lymphoma regulatory T-cell origin and function
Frontiers in ImmunologyIntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez +16 more
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The role of regulatory T cells and follicular T helper cells in HBV infection
Frontiers in Immunology, 2023 Hepatitis B has become one of the major global health threats, especially in developing countries and regions. Hepatitis B virus infection greatly increases the risk for liver diseases such as cirrhosis and cancer.
Nengqi Lin +13 more
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Cell Reports, 2019 Summary: Follicular regulatory T (TFR) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance.
Lei Wang +13 more
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T Follicular Regulatory Cells and Antibody Responses in Transplantation. [PDF]
Transplantation, 2018 Abstract De novo donor-specific antibody (DSA) formation is a major problem in transplantation, and associated with long-term graft decline and loss as well as sensitization, limiting future transplant options. Forming high-affinity, long-lived antibody responses involves a process called the germinal center (GC) reaction, and requires ...
Wallin EF.
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T follicular regulatory cells: Guardians of the germinal centre? [PDF]
Scand J Immunol, 2020 AbstractIt is a central tenet of the clonal selection theory, that lymphocyte repertoires are tolerized to self‐antigens during their ontogeny. Germinal centres are the sites in secondary lymphoid tissues where B cells undergo affinity maturation and class‐switching to produce high‐affinity antibodies.
Fahlquist Hagert C, Degn SE.
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Deficiency in T follicular regulatory cells promotes autoimmunity. [PDF]
J Exp Med, 2018 T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6fl/flFoxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses ...
Fu W +10 more
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Frontiers in Immunology, 2022 Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton +7 more
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