T follicular helper cells and T follicular regulatory cells in autoimmune diseases [PDF]
Frontiers in Immunology, 2023 T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi +4 more
doaj +6 more sources
T follicular helper and T follicular regulatory cells have different TCR specificity [PDF]
Nature Communications, 2017 T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras +9 more
doaj +9 more sources
Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals [PDF]
Cells, 2023 Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV ...
Bradley Salvatore +8 more
doaj +6 more sources
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells [PDF]
Frontiers in Immunology, 2023 IntroductionGermline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell
Etienne Masle-Farquhar +13 more
doaj +4 more sources
Control of Germinal Center Responses by T-Follicular Regulatory Cells [PDF]
Frontiers in Immunology, 2018 Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential role in the control of immune homeostasis. In order to control diverse types of immune responses Treg cells must themselves show functional heterogeneity to ...
James B. Wing +3 more
doaj +4 more sources
Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases [PDF]
Inflammation and Regeneration, 2021 T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation.
He Hao +2 more
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, 2021 With the compiling studies on the autoimmune pathogenesis in the developing of Sjögren's syndrome, the functional importance of T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr) was investigated, including our recent findings, among which various techniques for detecting Tfh and Tfr cells in Sjögren's syndrome have been reported ...
Sulan, Yu +5 more
openaire +3 more sources
T Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses [PDF]
Frontiers in Immunology, 2021 T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg) cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge.
Yisi Lu, Joe Craft, Joe Craft
doaj +2 more sources
Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells [PDF]
Frontiers in Immunology, 2019 The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving ...
Paul-Gydéon Ritvo +2 more
doaj +4 more sources
Unexpected Help: Follicular Regulatory T Cells in the Germinal Center
Frontiers in Immunology, 2018 Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma cells that secrete high-affinity and isotype-switched antibody (Ab).
Markus M. Xie, Alexander L. Dent
doaj +3 more sources