Follicular Regulatory T Cells in Systemic Lupus Erythematosus [PDF]
Journal of Immunology Research, 2021 Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses.
Xin Xia, Jun Yang, Shengjun Wang
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Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection [PDF]
Nature Communications, 2015 AbstractHuman and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity. Follicular regulatory T cells (TFR) are a recently characterized subset of lymphocytes that influence the germinal centre response through interactions with follicular ...
Brodie Miles +2 more
exaly +3 more sources
Follicular lymphoma regulatory T-cell origin and function
Frontiers in ImmunologyIntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez +16 more
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The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells [PDF]
Immunity, 2014 The receptor CTLA-4 has been implicated in controlling B cell responses, but the mechanisms by which CTLA-4 regulates antibody production are not known. Here we showed deletion of CTLA-4 in adult mice increased Tfh and Tfr cell numbers and augmented B cell responses.
Peter T Sage +2 more
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Increased circulating follicular regulatory T cells in Hashimoto’s thyroiditis
Autoimmunity, 2018 Objective: Follicular T helper (Tfh) cells are involved in the pathogenesis of Hashimoto's thyroiditis (HT), while follicular T regulatory (Tfr) cells inhibit Tfh cells, which mediate B cell responses. However, the role of Tfr cells in HT remains unclear.
Jiwei Zhao +6 more
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Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells [PDF]
Frontiers in Immunology, 2019 The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving ...
Paul-Gydéon Ritvo +2 more
doaj +4 more sources
T follicular helper cells, T follicular regulatory cells and autoimmunity. [PDF]
Int Immunol, 2016 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Zhu Y, Zou L, Liu YC.
europepmc +4 more sources
Human T follicular regulatory cells with helper and regulatory lineage origins
Nature Reviews Immunology, 2023 Quang Nhat Nguyen, Persephone Borrow
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Follicular regulatory T cell in atherosclerosis [PDF]
Journal of Leukocyte Biology, 2018 Abstract Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several ...
Baptista, Daniela +2 more
openaire +4 more sources
Deficiency in T follicular regulatory cells promotes autoimmunity. [PDF]
J Exp Med, 2018 T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6fl/flFoxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses ...
Fu W +10 more
europepmc +4 more sources