Results 31 to 40 of about 56,618 (238)

Follicular regulatory T cells inhibit the development of granzyme B–expressing follicular helper T cells [PDF]

JCI Insight, 2019
T follicular regulatory (TFR) cells are found in the germinal center (GC) response and help shape the antibody (Ab) response. However, the precise role of TFR cells in the GC is controversial. Here, we addressed TFR cell function using mice with impaired TFR cell development (Bcl6-flox/Foxp3-cre, or Bcl6FC mice), mice with augmented TFR cell ...
Markus M. Xie, Shuyi Fang, Qiang Chen, Hong Liu, Jun Wan, Alexander L. Dent   +5 more
openaire   +2 more sources

Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers

Nature Communications, 2023
Follicular helper T cells (TFH) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (TFR) prevent the emergence of self-reactive B cells and help to extinguish the reaction.
Julia Merkenschlager, Riza-Maria Berz, Victor Ramos, Maximilian Uhlig, Andrew J. MacLean, Carla R. Nowosad, Thiago Y. Oliveira, Michel C. Nussenzweig   +7 more
doaj   +1 more source

Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

Frontiers in Immunology, 2018
An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to ...
Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou   +7 more
doaj   +1 more source

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

Frontiers in Immunology, 2020
T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potential in
Diane G. Carnathan, Diane G. Carnathan, Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Ali H. Ellebedy, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Mohammed Ata Ur Rasheed, Matthias G. Pauthner, Matthias G. Pauthner, Gabriel Ozorowski, Gabriel Ozorowski, Rafi Ahmed, Rafi Ahmed, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Andrew B. Ward, Andrew B. Ward, Guido Silvestri, Guido Silvestri, Guido Silvestri, Shane Crotty, Shane Crotty, Shane Crotty, Michela Locci, Michela Locci, Michela Locci   +31 more
doaj   +1 more source

TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses

Frontiers in Immunology, 2022
Follicular T cells including T follicular helper (TFH) and T follicular regulatory (TFR) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC).
Cameron R. Bastow, Ervin E. Kara, Timona S. Tyllis, Carola G. Vinuesa, Shaun R. McColl, Iain Comerford   +5 more
doaj   +1 more source

T follicular regulatory cells in the regulation of B cell responses. [PDF]

Trends Immunol, 2015
High affinity antibodies result from interactions between B cells and T follicular helper (Tfh) cells in germinal centers (GCs). Recent studies have identified an effector subset of T regulatory cells termed T follicular regulatory (Tfr) cells that specifically controls GC responses by suppressing Tfh and B cells.
Sage PT, Sharpe AH.
europepmc   +4 more sources

Follicular regulatory T cells: a novel target for immunotherapy?

Clinical & Translational Immunology, 2020
High‐affinity antibodies are produced during multiple processes in germinal centres (GCs), where follicular helper T (Tfh) cells interact closely with B cells to support B‐cell survival, differentiation and proliferation.
Yao Huang, Zhe Chen, Hui Wang, Xin Ba, Pan Shen, Weiji Lin, Yu Wang, Kai Qin, Ying Huang, Shenghao Tu   +9 more
doaj   +1 more source

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

Cell Reports, 2020
Summary: Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of autoreactive TFH ...
Reza Nadafi, Catarina Gago de Graça, Eelco D. Keuning, Jasper J. Koning, Sander de Kivit, Tanja Konijn, Sandrine Henri, Jannie Borst, Rogier M. Reijmers, Lisa G.M. van Baarsen, Reina E. Mebius   +10 more
doaj   +1 more source

Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer

Tumor Biology, 2017
Gastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular
Hong Zhang, Rongxi Yue, Pengfei Zhao, Xuetao Yu, Junguo Li, Guoqing Ma, Jiahong Tang, Lixin Zhang, Liying Feng, Lidong Sun, Zongchang Song, Chunliang Guo, Ning Wang   +12 more
doaj   +1 more source

Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection.

PLoS Pathogens, 2016
During chronic HIV infection, viral replication is concentrated in secondary lymphoid follicles. Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle.
Brodie Miles, Shannon M Miller, Joy M Folkvord, David N Levy, Eva G Rakasz, Pamela J Skinner, Elizabeth Connick   +6 more
doaj   +1 more source