Results 51 to 60 of about 15,753,813 (238)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Higher frequency of circulating regulatory T cells is associated with poor outcomes in patients with colorectal cancer

Discover Oncology
Background While immune dysregulation significantly influences colorectal cancer (CRC) progression, this study aimed to investigate the levels of circulating regulatory T cells (cTreg) and their subsets, follicular helper T cells (cTfh), and follicular ...
Yan Lu, Haoyang Guo, Taotao Guo, Longyi Zhang, Xinling Pan   +4 more
doaj   +1 more source

Detection of Mouse Natural Killer T Follicular Helper (NKTFH) Cells by Flow Cytometry

, 2016
Natural killer T follicular helper (NKTFH) cell, a recently identified B-cell helper innate cell population, can be easily missed due to its low frequency and the fact that it only forms upon immunization or infection with glycolipid-containing antigens ...
Garcia De Vinuesa, Maria Carola, Chang, Pheh   +1 more
core   +1 more source

Regulatory T-Cell Phenotyping Using CyTOF

, 2023
Regulatory T cells are an important component of the immune system that plays a key role in maintaining homeostasis. Identification of distinct regulatory T cell subsets is essential to understand their function.
Sjögren, Florence,, Magnusson, Louise,, Casas, Rosaura,, Barcenilla, Hugo,, Pihl, Mikael,   +4 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
core   +1 more source

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

Cell Reports, 2020
Summary: Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of autoreactive TFH ...
Reza Nadafi, Catarina Gago de Graça, Eelco D. Keuning, Jasper J. Koning, Sander de Kivit, Tanja Konijn, Sandrine Henri, Jannie Borst, Rogier M. Reijmers, Lisa G.M. van Baarsen, Reina E. Mebius   +10 more
doaj   +1 more source

B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions

Frontiers in Cell and Developmental Biology, 2022
B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan, Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K James, Niels Olsen Saraiva Camara, S.M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Quan Gong, Zheng Liu, Chaohong Liu   +17 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Regulatory roles of IL-10-producing human follicular T cells. [PDF]

, 2019
Mucosal lymphoid tissues such as human tonsil are colonized by bacteria and exposed to ingested and inhaled antigens, requiring tight regulation of immune responses.
Matthew C. Cook, Doglioni, Claudio, Sayin, I., Vinuesa, Carola, Papa, Ilenia, Cook, Matthew C, Pablo F. Cañete, Cañete, P.F., Roco, Jonathan A, Paula Gonzalez-Figueroa, Cuenca, Marta, Sweet, R.A., Canaday, David H., Barry, Emma, Papa, I., Bassett, Katharine J., Vinuesa, Carola G., Michael Meyer-Hermann, Lopez, Angel F., Sweet, Rebecca A., Barbara Fazekas de St Groth, David H. Canaday, Gonzalez-Figueroa, P., Barry, E., Marta Cuenca, Bassett, Katharine J, Meyer-Hermann, M., Cañete, Pablo F, Fazekas de St Groth, B., Angel Lopez, Fazekas de St Groth, Barbara, Ismail Sayin, Emma Barry, Sakaguchi, Shimon, Shimon Sakaguchi, Rebecca A. Sweet, Canaday, D.H., Bassett, K.J., Lopez, Angel, Barry, E, Roco Alegre, Jonathan, Bassett, Katharine, Ilenia Papa, Vinuesa, C.G., Ohkura, Naganari, Claudio Doglioni, Carola G. Vinuesa, Cuenca, M., Cook, M.C., Canaday, David H, Bolton, H., Sweet, Rebecca, Cook, Matthew C., Sayin, Ismail, Holly Bolton, Sweet, Rebecca A, Roco, Jonathan A., Naganari Ohkura, Sakaguchi, S., Cañete, Pablo F., Ohkura, N., F Canete, Pablo, Gonzalez-Figueroa, Paula, Jonathan A. Roco, Lopez, A., Meyer-Hermann, Michael, Sakaguchi, Shimon, Prof, Doglioni, C., Roco, J.A., Vinuesa, Carola G, Bolton, Holly, Katharine J. Bassett, Cook, Matthew   +72 more
core   +1 more source