Results 31 to 40 of about 15,978,556 (170)
Nature Communications, 2017 IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.
Christoph Jandl +14 more
doaj +2 more sources
T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]
, 2012 Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F. +5 more
core +4 more sources
T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]
International Immunology, 2015 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
openaire +2 more sources
Mechanisms of t follicular regulatory cell differentiation
Respostas imunológicas humorais protetoras coordenadas pelas células B, quer em resposta a infeções ou à vacinação, requerem a participação de células T. Entre estas, as células T foliculares auxiliares (Tfh) emergiram como elementos-chave, fornecendo ajuda às células B e facilitando a produção de anticorpos de alta afinidade.
Ribeiro, Filipa
core +3 more sources
Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. [PDF]
Sci Immunol, 2017 Follicular regulatory T cells promote the germinal center response after viral infection through provision of IL-10.
Laidlaw BJ +9 more
europepmc +2 more sources
Frontiers in Transplantation, 2023 IntroductionHighly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss.
C. Dudreuilh +16 more
doaj +1 more source
Frontiers in Medicine, 2021 Objective: Recent studies on follicular regulatory T (Tfr) and follicular helper T (Tfh) cells suggest that they may participate in the pathogenesis of rheumatoid arthritis (RA).
Rui Su +9 more
doaj +1 more source
Emerging role of follicular regulatory T-cells in neuroimmunological disorders. [PDF]
Curr Opin ImmunolImmune tolerance is essential for preventing self-damage while maintaining effective immune responses against foreign insults. Disruptions in this balance contribute to autoimmune and inflammatory conditions, including neuroimmunological disorders that are characterized by aberrant inflammation in the nervous system. Follicular regulatory T (TFR) cells,
Opoku S, Guo Q, Leavenworth JW.
europepmc +4 more sources
Follicular regulatory T cells inhibit the development of granzyme B-expressing follicular helper T cells. [PDF]
JCI Insight, 2019 T follicular regulatory (TFR) cells are found in the germinal center (GC) response and help shape the antibody (Ab) response. However, the precise role of TFR cells in the GC is controversial. Here, we addressed TFR cell function using mice with impaired TFR cell development ( Bcl6-flox/Foxp3-cre
Xie MM +5 more
europepmc +4 more sources
The impact of molecular alterations and the immune microenvironment on the natural history of Follicular Lymphoma including transformation to Diffuse Large B cell Lymphoma [PDF]
, 2009 PhDThe natural history of follicular lymphoma is heterogeneous with numerous relapses and remissions over many years. A substantial number of patients suffer an aggressive disease course with death due to disease within 5 years of diagnosis.
Lee, Abigail Mary
core +3 more sources