Control of the Germinal Center by Follicular Regulatory T Cells During Infection [PDF]
Front Immunol, 2018 Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact adaptive immune responses in the lymphoid follicles and germinal centers (GC).
B. Miles, E. Connick
semanticscholar +2 more sources
The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells [PDF]
Immunity, 2014 The receptor CTLA-4 has been implicated in controlling B cell responses, but the mechanisms by which CTLA-4 regulates antibody production are not known. Here we showed deletion of CTLA-4 in adult mice increased Tfh and Tfr cell numbers and augmented B cell responses.
Peter T Sage +2 more
exaly +3 more sources
Stat3 Is Important for Follicular Regulatory T Cell Differentiation [PDF]
PLOS ONE, 2016 The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper ...
Dent, Alexander +3 more
core +7 more sources
Higher frequency of circulating regulatory T cells is associated with poor outcomes in patients with colorectal cancer [PDF]
Discover OncologyBackground While immune dysregulation significantly influences colorectal cancer (CRC) progression, this study aimed to investigate the levels of circulating regulatory T cells (cTreg) and their subsets, follicular helper T cells (cTfh), and follicular ...
Yan Lu +4 more
doaj +2 more sources
Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells [PDF]
Nat Commun, 2016 T follicular regulatory (Tfr) cells are a subset of Foxp3+ regulatory T (Treg) cells that form in response to immunization or infection, which localize to the germinal centre where they control the magnitude of the response. Despite an increased interest
M. Aloulou +6 more
semanticscholar +2 more sources
Nature Medicine, 2011 Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of TFH numbers maintains self tolerance.
M. Linterman +13 more
semanticscholar +2 more sources
CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes [PDF]
Front Immunol, 2018 Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity ...
Zachary L. Benet +7 more
semanticscholar +2 more sources
Increased circulating follicular regulatory T cells in Hashimoto’s thyroiditis
Autoimmunity, 2018 Objective: Follicular T helper (Tfh) cells are involved in the pathogenesis of Hashimoto's thyroiditis (HT), while follicular T regulatory (Tfr) cells inhibit Tfh cells, which mediate B cell responses. However, the role of Tfr cells in HT remains unclear.
Jiwei Zhao +6 more
doaj +3 more sources
Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response [PDF]
Sci Immunol, 2017 B. Laidlaw +8 more
semanticscholar +2 more sources
Human T follicular regulatory cells with helper and regulatory lineage origins
Nature Reviews Immunology, 2023 Quang Nhat Nguyen, Persephone Borrow
exaly +4 more sources