Results 31 to 40 of about 14,961,937 (280)

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Cell Rep, 2020
Summary The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr)
Vanderleyden I, Fra-Bido SC, Innocentin S, Stebegg M, Okkenhaug H, Evans-Bailey N, Pierson W, Denton AE, Linterman MA.   +8 more
europepmc   +2 more sources

Immunosuppression Has Long-Lasting Effects on Circulating Follicular Regulatory T Cells in Kidney Transplant Recipients. [PDF]

Front Immunol, 2020
Background: FoxP3+ follicular regulatory T cells (Tfr) have been identified as the cell population controlling T follicular helper (Tfh) cells and B cells which, are both involved in effector immune responses against transplanted tissue.
Niu Q, Mendoza Rojas A, Dieterich M, Roelen DL, Clahsen-van Groningen MC, Wang L, van Gelder T, Hesselink DA, van Besouw NM, Baan CC.   +9 more
europepmc   +2 more sources

Detection of T Follicular Helper Cells and T Follicular Regulatory Cells in Experimental Sjögren’s Syndrome

, 2021
With the compiling studies on the autoimmune pathogenesis in the developing of Sjögren's syndrome, the functional importance of T follicular helper cells (Tfh) and T follicular regulatory cells (Tfr) was investigated, including our recent findings, among which various techniques for detecting Tfh and Tfr cells in Sjögren's syndrome have been reported ...
Xiang Lin, Feng, Y, Jiangang Shen, Shen, J, Lin, X, Sulan Yu, Meiling Wu, WU, M, Lu, L, Liwei Lu, Yun Feng, YU, S   +11 more
core   +3 more sources

Interleukin-10 from CD4⁺ follicular regulatory T cells promotes the germinal center response. [PDF]

Sci Immunol, 2017
Follicular regulatory T cells promote the germinal center response after viral infection through provision of IL-10. Probing the functions of follicular regulatory T cells CD4+ follicular regulatory T (Tfr) cells express key molecules that are associated
Laidlaw BJ, Lu Y, Amezquita RA, Weinstein JS, Vander Heiden JA, Gupta NT, Gupta NT, Kleinstein SH, Kaech SM, Craft J.   +9 more
europepmc   +2 more sources

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells

Frontiers in Immunology, 2023
IntroductionGermline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell
Etienne Masle-Farquhar, Etienne Masle-Farquhar, Yogesh Jeelall, Jacqueline White, Jacqueline White, Julia Bier, Julia Bier, Elissa K. Deenick, Elissa K. Deenick, Robert Brink, Robert Brink, Keisuke Horikawa, Christopher Carl Goodnow, Christopher Carl Goodnow   +13 more
doaj   +3 more sources

Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals

Cells, 2023
Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV ...
Bradley Salvatore, Rachel S. Resop, Brent R. Gordon, Marta Epeldegui, Otoniel Martinez-Maza, Begoña Comin-Anduix, Alex Lam, Ting-Ting Wu, Christel H. Uittenbogaart   +8 more
doaj   +5 more sources

Follicular lymphoma regulatory T-cell origin and function

Frontiers in Immunology
IntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez, Mehdi Alizadeh, Claire Lamaison, Alexis Saintamand, Céline Monvoisin, Rachel Jean, Rachel Jean, Laurent Deleurme, Laurent Deleurme, Jose Ignacio Martin-Subero, Céline Pangault, Céline Pangault, Michel Cogné, Patricia Amé-Thomas, Patricia Amé-Thomas, Karin Tarte, Karin Tarte   +16 more
doaj   +4 more sources

Altered ratio of circulating follicular regulatory T cells and follicular helper T cells during primary EBV infection. [PDF]

Clin Exp Med, 2020
Follicular help T cells (Tfh) play an important role in the activation and differentiation of B cells, while follicular regulatory T cells (Tfr) control Tfh and resulting humoral immune responses.
Qian J, Yu Q, Chen G, Wang M, Zhao Z, Zhang Y, Qiu L.   +6 more
europepmc   +2 more sources

The role of regulatory T cells and follicular T helper cells in HBV infection

Frontiers in Immunology, 2023
Hepatitis B has become one of the major global health threats, especially in developing countries and regions. Hepatitis B virus infection greatly increases the risk for liver diseases such as cirrhosis and cancer.
Nengqi Lin, Wei Yin, Heather Miller, Maria G. Byazrova, Andrés A. Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu   +13 more
doaj   +3 more sources

CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes. [PDF]

Front Immunol, 2018
Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity ...
Benet ZL, Marthi M, Ke F, Wu R, Turner JS, Gabayre JB, Ivanitskiy MI, Sethi SS, Grigorova IL.   +8 more
europepmc   +2 more sources