Results 41 to 50 of about 15,978,556 (170)

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine, 2020
Summary: Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies.
Seth D. Reighard, Stacey A. Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch, Jasmine A. Tuazon, Marat V. Khodoun, Leah C. Kottyan, David F. Smith, Hermine I. Brunner, Stephen N. Waggoner   +11 more
doaj   +1 more source

Deficiency in T follicular regulatory cells promotes autoimmunity [PDF]

Journal of Experimental Medicine, 2018
T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6fl/flFoxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses ...
Weiwei Fu, Xindong Liu, Xiang Lin, Han Feng, Lin Sun, Shuran Li, Hairong Chen, Hong Tang, Liwei Lu, Wei Jin, Chen Dong   +10 more
openaire   +2 more sources

ICOS controls Foxp3+ regulatory T-cell expansion, maintenance, and IL-10 production during helminth infection [PDF]

, 2012
Foxp3+ regulatory T (Treg) cells are key immune regulators during helminth infections, and identifying the mechanisms governing their induction is of principal importance for the design of treatments for helminth infections, allergies and autoimmunity ...
van der Werf, Nienke, MacDonald, Andrew, Redpath, Stephen A, Taylor, Matthew, Cervera, Ana M, Macdonald, Andrew S; id_orcid, Cervera, Ana, Taylor, Matthew D., Maizels, Rick M, Andrew S. MacDonald, Cervera, Ana M., Gray, David, Maizels, Rick, Stephen A. Redpath, Maizels, Rick M., Taylor, Matthew D, Macdonald, Andrew S.; id_orcid, Redpath, Stephen A., Matthew D. Taylor, Rick M. Maizels, David Gray, Nienke van der Werf, Ana M. Cervera   +22 more
core   +1 more source

Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

Frontiers in Immunology, 2018
An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to ...
Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou   +7 more
doaj   +1 more source

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

Frontiers in Immunology, 2020
T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potential in
Diane G. Carnathan, Diane G. Carnathan, Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Ali H. Ellebedy, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Mohammed Ata Ur Rasheed, Matthias G. Pauthner, Matthias G. Pauthner, Gabriel Ozorowski, Gabriel Ozorowski, Rafi Ahmed, Rafi Ahmed, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Andrew B. Ward, Andrew B. Ward, Guido Silvestri, Guido Silvestri, Guido Silvestri, Shane Crotty, Shane Crotty, Shane Crotty, Michela Locci, Michela Locci, Michela Locci   +31 more
doaj   +1 more source

T follicular regulatory cells in the regulation of B cell responses [PDF]

Trends in Immunology, 2015
High affinity antibodies result from interactions between B cells and T follicular helper (Tfh) cells in germinal centers (GCs). Recent studies have identified an effector subset of T regulatory cells termed T follicular regulatory (Tfr) cells that specifically controls GC responses by suppressing Tfh and B cells.
Peter T, Sage, Arlene H, Sharpe
openaire   +2 more sources

A T follicular helper cell origin for T regulatory type 1 cells

Cellular & Molecular Immunology, 2023
AbstractChronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+ T cells into T regulatory type 1 (TR1) cells, a subset of interleukin-10-producing Treg cells that do not express FOXP3. The identities of the progenitor(s) and transcriptional regulators of this T-cell subset remain unclear. Here, we show that the peptide-
Patricia Solé, Jun Yamanouchi, Josep Garnica, Muhammad Myn Uddin, Robert Clarke, Joel Moro, Nahir Garabatos, Shari Thiessen, Mireia Ortega, Santiswarup Singha, Debajyoti Mondal, César Fandos, Julio Saez-Rodriguez, Yang Yang, Pau Serra, Pere Santamaria   +15 more
openaire   +2 more sources

Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases

Inflammation and Regeneration, 2021
T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation.
He Hao, Shingo Nakayamada, Yoshiya Tanaka   +2 more
doaj   +1 more source

TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses

Frontiers in Immunology, 2022
Follicular T cells including T follicular helper (TFH) and T follicular regulatory (TFR) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC).
Cameron R. Bastow, Ervin E. Kara, Timona S. Tyllis, Carola G. Vinuesa, Shaun R. McColl, Iain Comerford   +5 more
doaj   +1 more source

T follicular regulatory cells: Guardians of the germinal centre? [PDF]

Scandinavian Journal of Immunology, 2020
AbstractIt is a central tenet of the clonal selection theory, that lymphocyte repertoires are tolerized to self‐antigens during their ontogeny. Germinal centres are the sites in secondary lymphoid tissues where B cells undergo affinity maturation and class‐switching to produce high‐affinity antibodies.
Cecilia Fahlquist Hagert, Søren E. Degn
openaire   +3 more sources