Results 21 to 30 of about 253,632 (296)

CD4+ follicular regulatory T cells optimize the influenza virus–specific B cell response [PDF]

J Exp Med, 2020
Seasonal influenza virus infections cause severe illness and a substantial number of deaths worldwide every year. This study reveals that the CD4+ follicular regulatory T cells are necessary for optimal antigen-specific humoral immunity following ...
Yisi Lu, R. Jiang, Alec W. Freyn, Jiawei Wang, Shirin Strohmeier, Katlyn Lederer, M. Locci, Hongyu Zhao, Davide Angeletti, K. O’Connor, S. Kleinstein, Raffael Nachbagauer, J. Craft   +12 more
semanticscholar   +2 more sources

Decreased circulating follicular regulatory T cells in patients with dilated cardiomyopathy [PDF]

Braz J Med Biol Res, 2021
Follicular regulatory T cells (Tfr) have critical functions in inflammatory and autoimmune disorders. The main purpose of the current work was to assess Tfr cell frequency in patients with dilated cardiomyopathy (DCM).
Xixi Liu, Wencai Zhang, Zhan-yin Han
semanticscholar   +2 more sources

Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes [PDF]

Diabetes, 2021
In the attempt to understand the origin of autoantibody (AAb) production in patients with and at risk for type 1 diabetes (T1D), multiple studies have analyzed and reported alterations in T follicular helper (Tfh) cells in presymptomatic AAb+ subjects ...
A. Vecchione, T. Jofra, Jolanda Gerosa, Kimberly Shankwitz, R. Di Fonte, G. Galvani, Elio Ippolito, M. Cicalese, Andrew R. Schultz, Howard R. Seay, Mariagrazia Favellato, G. Milardi, A. Stabilini, F. Ragogna, Pauline Grogan, E. Bianconi, A. Laurenzi, A. Caretto, R. Nano, Raffaela Melzi, N. Danzl, E. Bosi, L. Piemonti, A. Aiuti, T. Brusko, C. Petrovas, M. Battaglia, G. Fousteri   +27 more
semanticscholar   +2 more sources

Tnfaip6 Secreted by Bone Marrow–Derived Mesenchymal Stem Cells Attenuates TNBS-Induced Colitis by Modulating Follicular Helper T Cells and Follicular Regulatory T Cells Balance in Mice [PDF]

Front Pharmacol, 2021
Objective: To investigate the immunological mechanism of bone marrow–derived mesenchymal stem cells (BM-MSCs) in inflammatory bowel disease (IBD). Methods: Mice with 2,4,6-trinitrobenzene sulfonic acid (TNBS)–induced colitis were intraperitoneally ...
Guang-li Gu, Xiaodan Lv, Geng-feng Liu, Rui-zhi Zeng, Shiquan Li, Lan Chen, Zhaoliang Liang, Hui-qin Wang, Fei Lu, L. Zhan, Xiaoping Lv   +10 more
semanticscholar   +2 more sources

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses [PDF]

Nat Immunol, 2019
Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T (TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody responses to foreign antigens and autoantigens in vivo is still ...
Rachel L. Clement, Joe Daccache, M. Mohammed, Alos B. Diallo, B. Blazar, V. Kuchroo, S. Lovitch, A. Sharpe, P. Sage   +8 more
semanticscholar   +2 more sources

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

Cell Rep, 2020
Summary The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr)
I. Vanderleyden, Sigrid Fra-Bido, S. Innocentin, Marisa Stebegg, H. Okkenhaug, Nicola Evans-Bailey, Wim Pierson, A. Denton, M. Linterman   +8 more
semanticscholar   +2 more sources

Immunosuppression Has Long-Lasting Effects on Circulating Follicular Regulatory T Cells in Kidney Transplant Recipients [PDF]

Front Immunol, 2020
Background: FoxP3+ follicular regulatory T cells (Tfr) have been identified as the cell population controlling T follicular helper (Tfh) cells and B cells which, are both involved in effector immune responses against transplanted tissue.
Qian Niu, Aleixandra Mendoza Rojas, Marjolein Dieterich, D. Roelen, M. C. Clahsen‐van Groningen, Lanlan Wang, T. van Gelder, D. Hesselink, N. V. van Besouw, C. Baan   +9 more
semanticscholar   +2 more sources

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells

Frontiers in Immunology, 2023
IntroductionGermline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell
Etienne Masle-Farquhar, Etienne Masle-Farquhar, Yogesh Jeelall, Jacqueline White, Jacqueline White, Julia Bier, Julia Bier, Elissa K. Deenick, Elissa K. Deenick, Robert Brink, Robert Brink, Keisuke Horikawa, Christopher Carl Goodnow, Christopher Carl Goodnow   +13 more
doaj   +3 more sources

Follicular lymphoma regulatory T-cell origin and function

Frontiers in Immunology
IntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez, Mehdi Alizadeh, Claire Lamaison, Alexis Saintamand, Céline Monvoisin, Rachel Jean, Rachel Jean, Laurent Deleurme, Laurent Deleurme, Jose Ignacio Martin-Subero, Céline Pangault, Céline Pangault, Michel Cogné, Patricia Amé-Thomas, Patricia Amé-Thomas, Karin Tarte, Karin Tarte   +16 more
doaj   +4 more sources

Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy [PDF]

Nat Immunol, 2021
S. Eschweiler, J. Clarke, C. Ramírez-Suástegui, B. Panwar, A. Madrigal, S. Chee, I. Karydis, E. Woo, A. Alzetani, Somaia E. Elsheikh, C. Hanley, G. Thomas, P. Friedmann, T. Sanchez-Elsner, F. Ay, C. Ottensmeier, P. Vijayanand   +16 more
semanticscholar   +2 more sources