Results 21 to 30 of about 14,961,937 (280)

Inflammatory Cytokine-Neutralizing Antibody Treatment Prevented Increases in Follicular Helper T Cells and Follicular Regulatory T Cells in a Mouse Model of Arthritis. [PDF]

J Inflamm Res, 2022
Background Follicular T helper (TFH) and follicular regulatory T (TFR) cells play important roles in humoral immunity. Nevertheless, their significance in rheumatoid arthritis (RA) pathogenesis has not been fully elucidated.
Zeng X, Lu S, Li M, Zheng M, Liu T, Kang R, Xu L, Xu Q, Song Y, Liu C.   +9 more
europepmc   +2 more sources

Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. [PDF]

EBioMedicine, 2020
Background Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder with a high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota has been observed in RA patients.
Takahashi D, Hoshina N, Kabumoto Y, Maeda Y, Suzuki A, Tanabe H, Isobe J, Yamada T, Muroi K, Yanagisawa Y, Nakamura A, Fujimura Y, Saeki A, Ueda M, Matsumoto R, Asaoka H, Clarke JM, Harada Y, Umemoto E, Komatsu N, Okada T, Takayanagi H, Takeda K, Tomura M, Hase K.   +24 more
europepmc   +2 more sources

Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells. [PDF]

Nat Commun
Pathogenic antibodies produced by alloreactive B cells mediate antibody-mediated rejection after kidney transplantation, but the mechanisms remain poorly understood.
Zhang H, Podestà MA, Cavazzoni CB, Wu Y, Lee JM, Li X, Raeder PL, Chandrakar P, Gempler M, Richardson S, Ghosh D, Sayin I, Blazar BR, Abdi R, Weins A, Chong AS, Sage PT.   +16 more
europepmc   +2 more sources

Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis. [PDF]

J Neuroinflammation, 2021
Background Follicular regulatory T (T FR ) cells are essential for the regulation of germinal center (GC) response and humoral self-tolerance. Dysregulated follicular helper T (T FH ) cell-GC-antibody (Ab) response secondary to dysfunctional T FR cells ...
Luo L, Hu X, Dixon ML, Pope BJ, Leavenworth JD, Raman C, Meador WR, Leavenworth JW.   +7 more
europepmc   +2 more sources

Decreased circulating follicular regulatory T cells in patients with dilated cardiomyopathy. [PDF]

Braz J Med Biol Res, 2021
Follicular regulatory T cells (Tfr) have critical functions in inflammatory and autoimmune disorders. The main purpose of the current work was to assess Tfr cell frequency in patients with dilated cardiomyopathy (DCM).
Liu X, Zhang W, Han Z.
europepmc   +2 more sources

Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes. [PDF]

Diabetes, 2021
In the attempt to understand the origin of autoantibody (AAb) production in patients with and at risk for type 1 diabetes (T1D), multiple studies have analyzed and reported alterations in T follicular helper (Tfh) cells in presymptomatic AAb+ subjects ...
Vecchione A, Jofra T, Gerosa J, Shankwitz K, Di Fonte R, Galvani G, Ippolito E, Cicalese MP, Schultz AR, Seay HR, Favellato M, Milardi G, Stabilini A, Ragogna F, Grogan P, Bianconi E, Laurenzi A, Caretto A, Nano R, Melzi R, Danzl N, Bosi E, Piemonti L, Aiuti A, Brusko T, Petrovas C, Battaglia M, Fousteri G.   +27 more
europepmc   +2 more sources

Immunological dysregulation of follicular helper T cells, follicular regulatory T cells, and follicular cytotoxic T cells is associated with disease activity and identifies exploratory immune patterns in rheumatoid arthritis [PDF]

Frontiers in Immunology
BackgroundThe onset and progression of rheumatoid arthritis (RA) are linked to autoantibody production driven by dysregulated germinal center (GC) responses. Follicular helper T cells (Tfh), follicular regulatory T cells (Tfr), and follicular cytotoxic T
Yuxin Fan, Yuxin Fan, Yuxin Fan, Baochen Li, Baochen Li, Baochen Li, Ruihe Wu, Ruihe Wu, Ruihe Wu, Xiaoyang Liu, Xiaoyang Liu, Xiaoyang Liu, Xiaoyu Zi, Xiaoyu Zi, Xiaoyu Zi, Yuhuan Xie, Yuhuan Xie, Yuhuan Xie, Chong Gao, Caihong Wang, Caihong Wang, Caihong Wang   +21 more
doaj   +2 more sources

Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response [PDF]

Nature Medicine, 2011
Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of TFH numbers maintains self tolerance.
M. Linterman, Wim Pierson, S. K. Lee, A. Kallies, Shimpei Kawamoto, Tim F. Rayner, Monika Srivastava, D. Divekar, L. Beaton, Jennifer J. Hogan, S. Fagarasan, A. Liston, Kenneth G. C. Smith, Carola G. Vinuesa   +13 more
semanticscholar   +2 more sources

Tnfaip6 Secreted by Bone Marrow-Derived Mesenchymal Stem Cells Attenuates TNBS-Induced Colitis by Modulating Follicular Helper T Cells and Follicular Regulatory T Cells Balance in Mice. [PDF]

Front Pharmacol, 2021
Objective: To investigate the immunological mechanism of bone marrow–derived mesenchymal stem cells (BM-MSCs) in inflammatory bowel disease (IBD). Methods: Mice with 2,4,6-trinitrobenzene sulfonic acid (TNBS)–induced colitis were intraperitoneally ...
Gu G, Lv X, Liu G, Zeng R, Li S, Chen L, Liang Z, Wang H, Lu F, Zhan L, Lv X.   +10 more
europepmc   +2 more sources

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. [PDF]

Nat Immunol, 2019
Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T (TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody responses to foreign antigens and autoantigens in vivo is still ...
Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT.   +8 more
europepmc   +2 more sources