Results 21 to 30 of about 15,978,556 (170)

Follicular regulatory T cell in atherosclerosis [PDF]

Journal of Leukocyte Biology, 2018
Abstract Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several ...
Baptista, Daniela, Mach, François, Brandt, Karim   +2 more
openaire   +5 more sources

CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells

Frontiers in Immunology, 2023
IntroductionGermline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell
Etienne Masle-Farquhar, Etienne Masle-Farquhar, Yogesh Jeelall, Jacqueline White, Jacqueline White, Julia Bier, Julia Bier, Elissa K. Deenick, Elissa K. Deenick, Robert Brink, Robert Brink, Keisuke Horikawa, Christopher Carl Goodnow, Christopher Carl Goodnow   +13 more
doaj   +3 more sources

Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals

Cells, 2023
Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV ...
Bradley Salvatore, Rachel S. Resop, Brent R. Gordon, Marta Epeldegui, Otoniel Martinez-Maza, Begoña Comin-Anduix, Alex Lam, Ting-Ting Wu, Christel H. Uittenbogaart   +8 more
doaj   +5 more sources

Follicular lymphoma regulatory T-cell origin and function

Frontiers in Immunology
IntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez, Mehdi Alizadeh, Claire Lamaison, Alexis Saintamand, Céline Monvoisin, Rachel Jean, Rachel Jean, Laurent Deleurme, Laurent Deleurme, Jose Ignacio Martin-Subero, Céline Pangault, Céline Pangault, Michel Cogné, Patricia Amé-Thomas, Patricia Amé-Thomas, Karin Tarte, Karin Tarte   +16 more
doaj   +4 more sources

SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation

Science, 2020
SOSTDC1 for germinal center regulation T follicular helper (T FH ) cells are CD4 + T cells that facilitate B cell antibody production and B cell memory responses in the germinal centers (GCs) of lymphoid organs. These activities are in
Xin Wu, Yun Wang, Rui Huang, Qujing Gai, Haofei Liu, Meimei Shi, Xiang Zhang, Yonglin Zuo, Longjuan Chen, Qiwen Zhao, Yu Shi, Fengchao Wang, Xiaowei Yan, Huiping Lu, Senlin Xu, Xiaohong Yao, Lin Chen, Xia Zhang, Qiang Tian, Ziyan Yang, Bo Zhong, Chen Dong, Yan Wang, Xiu-Wu Bian, Xindong Liu   +24 more
core   +4 more sources

The role of regulatory T cells and follicular T helper cells in HBV infection

Frontiers in Immunology, 2023
Hepatitis B has become one of the major global health threats, especially in developing countries and regions. Hepatitis B virus infection greatly increases the risk for liver diseases such as cirrhosis and cancer.
Nengqi Lin, Wei Yin, Heather Miller, Maria G. Byazrova, Andrés A. Herrada, Kamel Benlagha, Pamela Lee, Fei Guan, Jiahui Lei, Quan Gong, Quan Gong, Youqing Yan, Alexander Filatov, Chaohong Liu   +13 more
doaj   +3 more sources

The multifaceted functions of follicular regulatory T cells. [PDF]

Curr Opin Immunol, 2020
The immune system is capable of generating robust antibody responses to foreign antigens during infection and vaccination, while simultaneously limiting antibodies to self-antigens. T follicular regulatory (Tfr) cells are a subset of follicular T cell with specialized roles in regulating humoral immunity.
Sage PT, Sharpe AH.
europepmc   +4 more sources

The epigenetic trajectory of type 1 regulatory T cells

eLife
The epigenome of T follicular helper cells prepares them for conversion into type 1 regulatory T cells.
David P Turicek, Xiaoxiao Wan
doaj   +2 more sources

Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor [PDF]

Cell Reports, 2019
Summary: Follicular regulatory T (TFR) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance.
Lei Wang, Erxia Shen, Lin Luo, Hardis Rabe, Qin Wang, Jie Yin, Xueying Yang, Wenquan Liu, Jessica M. Sido, Hidetoshi Nakagawa, Lin Ao, Hye-Jung Kim, Harvey Cantor, Jianmei W. Leavenworth   +13 more
doaj   +2 more sources

The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia [PDF]

Scientific Reports, 2019
Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are not fully understood.
Yuhan Gao, Haiqiang Jin, Ding Nan, Weiwei Yu, Jianhua Zhang, Ying Yang, Ruiqin Hou, Ranran Qin, Hongjun Hao, Yongan Sun, Wenqin Tian   +10 more
doaj   +3 more sources