Results 21 to 30 of about 58,284 (237)

T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]

International Immunology, 2015
Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
openaire   +2 more sources

Follicular regulatory T cell in atherosclerosis [PDF]

Journal of Leukocyte Biology, 2018
Abstract Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several ...
Baptista, Daniela, Mach, François, Brandt, Karim   +2 more
openaire   +4 more sources

Highly sensitised individuals present a distinct Treg signature compared to unsensitised individuals on haemodialysis

Frontiers in Transplantation, 2023
IntroductionHighly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss.
C. Dudreuilh, C. Dudreuilh, S. Basu, S. Basu, O. Shaw, H. Burton, H. Burton, N. Mamode, N. Mamode, F. Harris, T. Tree, P. Nedyalko, M. Terranova-Barberio, G. Lombardi, C. Scottà, A. Dorling, A. Dorling   +16 more
doaj   +1 more source

Altered Distribution of Circulating T Follicular Helper-Like Cell Subsets in Rheumatoid Arthritis Patients

Frontiers in Medicine, 2021
Objective: Recent studies on follicular regulatory T (Tfr) and follicular helper T (Tfh) cells suggest that they may participate in the pathogenesis of rheumatoid arthritis (RA).
Rui Su, Yanyan Wang, Fangyuan Hu, Baochen Li, Qiaoling Guo, Xinyu Zheng, Yue Liu, Chong Gao, Xiaofeng Li, Caihong Wang   +9 more
doaj   +1 more source

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice. [PDF]

Eur J Immunol, 2016
Wu H, Chen Y, Liu H, Xu LL, Teuscher P, Wang S, Lu S, Dent AL.   +7 more
europepmc   +2 more sources

Follicular regulatory T cells inhibit the development of granzyme B-expressing follicular helper T cells. [PDF]

JCI Insight, 2019
T follicular regulatory (TFR) cells are found in the germinal center (GC) response and help shape the antibody (Ab) response. However, the precise role of TFR cells in the GC is controversial. Here, we addressed TFR cell function using mice with impaired TFR cell development ( Bcl6-flox/Foxp3-cre
Xie MM, Fang S, Chen Q, Liu H, Wan J, Dent AL.   +5 more
europepmc   +4 more sources

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine, 2020
Summary: Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies.
Seth D. Reighard, Stacey A. Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch, Jasmine A. Tuazon, Marat V. Khodoun, Leah C. Kottyan, David F. Smith, Hermine I. Brunner, Stephen N. Waggoner   +11 more
doaj   +1 more source

Deficiency in T follicular regulatory cells promotes autoimmunity [PDF]

Journal of Experimental Medicine, 2018
T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6fl/flFoxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses ...
Weiwei Fu, Xindong Liu, Xiang Lin, Han Feng, Lin Sun, Shuran Li, Hairong Chen, Hong Tang, Liwei Lu, Wei Jin, Chen Dong   +10 more
openaire   +2 more sources

Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

Frontiers in Immunology, 2018
An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to ...
Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou   +7 more
doaj   +1 more source

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

Frontiers in Immunology, 2020
T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potential in
Diane G. Carnathan, Diane G. Carnathan, Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Ali H. Ellebedy, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Mohammed Ata Ur Rasheed, Matthias G. Pauthner, Matthias G. Pauthner, Gabriel Ozorowski, Gabriel Ozorowski, Rafi Ahmed, Rafi Ahmed, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Andrew B. Ward, Andrew B. Ward, Guido Silvestri, Guido Silvestri, Guido Silvestri, Shane Crotty, Shane Crotty, Shane Crotty, Michela Locci, Michela Locci, Michela Locci   +31 more
doaj   +1 more source