Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection [PDF]
Nat Commun, 2015 Human and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity.
B. Miles +11 more
semanticscholar +7 more sources
The multifaceted functions of follicular regulatory T cells. [PDF]
Curr Opin Immunol, 2020 The immune system is capable of generating robust antibody responses to foreign antigens during infection and vaccination, while simultaneously limiting antibodies to self-antigens.
P. Sage, A. Sharpe
semanticscholar +5 more sources
Follicular regulatory T cells inhibit the development of granzyme B-expressing follicular helper T cells. [PDF]
JCI Insight, 2019 T follicular regulatory (TFR) cells are found in the germinal center (GC) response and help shape the antibody (Ab) response. However, the precise role of TFR cells in the GC is controversial. Here, we addressed TFR cell function using mice with impaired
Markus M. Xie +5 more
semanticscholar +5 more sources
Follicular regulatory T cells produce neuritin to regulate B cells.
Cell, 2021 Regulatory T cells prevent the emergence of autoantibodies and excessive IgE, but the precise mechanisms are unclear. Here, we show that BCL6-expressing Tregs, known as follicular regulatory T (Tfr) cells, produce abundant neuritin protein that targets B
Paula Gonzalez-Figueroa +8 more
semanticscholar +5 more sources
T follicular helper and T follicular regulatory cells have different TCR specificity [PDF]
Nature Communications, 2017 T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras +9 more
doaj +7 more sources
Altered ratio of circulating follicular regulatory T cells and follicular helper T cells during primary EBV infection [PDF]
Clin Exp Med, 2020 Follicular help T cells (Tfh) play an important role in the activation and differentiation of B cells, while follicular regulatory T cells (Tfr) control Tfh and resulting humoral immune responses.
J. Qian +6 more
semanticscholar +5 more sources
Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner [PDF]
Frontiers in Immunology, 2022 Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton +7 more
doaj +2 more sources
T follicular helper cells and T follicular regulatory cells in autoimmune diseases
Frontiers in Immunology, 2023 T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi +4 more
doaj +3 more sources
Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells [PDF]
EBioMedicine, 2020 Background Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder with a high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota has been observed in RA patients.
D. Takahashi +24 more
semanticscholar +2 more sources
Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis [PDF]
J Neuroinflammation, 2021 Background Follicular regulatory T (T FR ) cells are essential for the regulation of germinal center (GC) response and humoral self-tolerance. Dysregulated follicular helper T (T FH ) cell-GC-antibody (Ab) response secondary to dysfunctional T FR cells ...
Lin Luo +7 more
semanticscholar +2 more sources