Results 11 to 20 of about 58,284 (237)
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. [PDF]
Nat Commun, 2015 AbstractHuman and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity. Follicular regulatory T cells (TFR) are a recently characterized subset of lymphocytes that influence the germinal centre response through interactions with follicular ...
Miles B +11 more
europepmc +5 more sources
Frontiers in Immunology, 2023 IntroductionGermline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell
Etienne Masle-Farquhar +13 more
doaj +3 more sources
Cells, 2023 Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV ...
Bradley Salvatore +8 more
doaj +5 more sources
Follicular lymphoma regulatory T-cell origin and function
Frontiers in ImmunologyIntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez +16 more
doaj +4 more sources
The role of regulatory T cells and follicular T helper cells in HBV infection
Frontiers in Immunology, 2023 Hepatitis B has become one of the major global health threats, especially in developing countries and regions. Hepatitis B virus infection greatly increases the risk for liver diseases such as cirrhosis and cancer.
Nengqi Lin +13 more
doaj +3 more sources
T Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses
Frontiers in Immunology, 2021 T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg) cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge.
Yisi Lu, Joe Craft, Joe Craft
doaj +3 more sources
The Imbalance of Circulating Follicular Helper T Cells and Follicular Regulatory T Cells Is Associated With Disease Activity in Patients With Ulcerative Colitis [PDF]
Frontiers in Immunology, 2020 Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon and rectum, in which the abnormality of B cells is involved in both its pathogenesis and progression.
Yan Long +8 more
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Control of Germinal Center Responses by T-Follicular Regulatory Cells
Frontiers in Immunology, 2018 Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential role in the control of immune homeostasis. In order to control diverse types of immune responses Treg cells must themselves show functional heterogeneity to ...
James B. Wing +3 more
doaj +3 more sources
The multifaceted functions of follicular regulatory T cells. [PDF]
Curr Opin Immunol, 2020 The immune system is capable of generating robust antibody responses to foreign antigens during infection and vaccination, while simultaneously limiting antibodies to self-antigens. T follicular regulatory (Tfr) cells are a subset of follicular T cell with specialized roles in regulating humoral immunity.
Sage PT, Sharpe AH.
europepmc +4 more sources
The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia [PDF]
Scientific Reports, 2019 Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are not fully understood.
Yuhan Gao +10 more
doaj +3 more sources