The multifaceted functions of follicular regulatory T cells. [PDF]
Curr Opin Immunol, 2020 The immune system is capable of generating robust antibody responses to foreign antigens during infection and vaccination, while simultaneously limiting antibodies to self-antigens.
Sage PT, Sharpe AH.
europepmc +5 more sources
T follicular helper cells and T follicular regulatory cells in autoimmune diseases
Frontiers in Immunology, 2023 T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi +4 more
doaj +5 more sources
T follicular helper and T follicular regulatory cells have different TCR specificity [PDF]
Nature Communications, 2017 T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras +9 more
doaj +7 more sources
Follicular regulatory T cells produce neuritin to regulate B cells
Cell, 2021 Regulatory T cells prevent the emergence of autoantibodies and excessive IgE, but the precise mechanisms are unclear. Here, we show that BCL6-expressing Tregs, known as follicular regulatory T (Tfr) cells, produce abundant neuritin protein that targets B
Michelle Linterman +2 more
exaly +6 more sources
Follicular regulatory T cells inhibit the development of granzyme B-expressing follicular helper T cells. [PDF]
JCI Insight, 2019 T follicular regulatory (TFR) cells are found in the germinal center (GC) response and help shape the antibody (Ab) response. However, the precise role of TFR cells in the GC is controversial. Here, we addressed TFR cell function using mice with impaired
Xie MM +5 more
europepmc +5 more sources
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection [PDF]
Nature Communications, 2015 Human and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity.
Martin McCarter +2 more
exaly +4 more sources
Association of follicular helper T and follicular regulatory T cells with severity and hyperglycemia in hospitalized COVID-19 patients. [PDF]
Virulence, 2022 We aimed to determine the levels of follicular helper T (Tfh) and follicular regulatory T (Tfr) cells in COVID-19 patients and determine whether their levels correlated with disease severity and presence of hyperglycemia. This study was carried out in 34
Zahran AM +10 more
europepmc +2 more sources
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy. [PDF]
Nat Immunol, 2021 Immune-checkpoint blockade (ICB) has shown remarkable clinical success in boosting antitumor immunity. However, the breadth of its cellular targets and specific mode of action remain elusive.
Eschweiler S +16 more
europepmc +2 more sources
CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response. [PDF]
J Exp Med, 2021 Seasonal influenza virus infections cause severe illness and a substantial number of deaths worldwide every year. This study reveals that the CD4+ follicular regulatory T cells are necessary for optimal antigen-specific humoral immunity following ...
Lu Y +12 more
europepmc +2 more sources
Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner [PDF]
Frontiers in Immunology, 2022 Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton +7 more
doaj +2 more sources