Results 61 to 70 of about 15,978,556 (170)

Detection of Mouse Natural Killer T Follicular Helper (NKTFH) Cells by Flow Cytometry

, 2016
Natural killer T follicular helper (NKTFH) cell, a recently identified B-cell helper innate cell population, can be easily missed due to its low frequency and the fact that it only forms upon immunization or infection with glycolipid-containing antigens ...
Garcia De Vinuesa, Maria Carola, Chang, Pheh   +1 more
core   +1 more source

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

Cell Reports, 2020
Summary: Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of autoreactive TFH ...
Reza Nadafi, Catarina Gago de Graça, Eelco D. Keuning, Jasper J. Koning, Sander de Kivit, Tanja Konijn, Sandrine Henri, Jannie Borst, Rogier M. Reijmers, Lisa G.M. van Baarsen, Reina E. Mebius   +10 more
doaj   +1 more source

B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions

Frontiers in Cell and Developmental Biology, 2022
B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan, Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K James, Niels Olsen Saraiva Camara, S.M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Quan Gong, Zheng Liu, Chaohong Liu   +17 more
doaj   +1 more source

Regulatory T-Cell Phenotyping Using CyTOF

, 2023
Regulatory T cells are an important component of the immune system that plays a key role in maintaining homeostasis. Identification of distinct regulatory T cell subsets is essential to understand their function.
Sjögren, Florence,, Magnusson, Louise,, Casas, Rosaura,, Barcenilla, Hugo,, Pihl, Mikael,   +4 more
core   +1 more source

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
core   +1 more source

Regulatory roles of IL-10-producing human follicular T cells. [PDF]

, 2019
Mucosal lymphoid tissues such as human tonsil are colonized by bacteria and exposed to ingested and inhaled antigens, requiring tight regulation of immune responses.
Matthew C. Cook, Doglioni, Claudio, Sayin, I., Vinuesa, Carola, Papa, Ilenia, Cook, Matthew C, Pablo F. Cañete, Cañete, P.F., Roco, Jonathan A, Paula Gonzalez-Figueroa, Cuenca, Marta, Sweet, R.A., Canaday, David H., Barry, Emma, Papa, I., Bassett, Katharine J., Vinuesa, Carola G., Michael Meyer-Hermann, Lopez, Angel F., Sweet, Rebecca A., Barbara Fazekas de St Groth, David H. Canaday, Gonzalez-Figueroa, P., Barry, E., Marta Cuenca, Bassett, Katharine J, Meyer-Hermann, M., Cañete, Pablo F, Fazekas de St Groth, B., Angel Lopez, Fazekas de St Groth, Barbara, Ismail Sayin, Emma Barry, Sakaguchi, Shimon, Shimon Sakaguchi, Rebecca A. Sweet, Canaday, D.H., Bassett, K.J., Lopez, Angel, Barry, E, Roco Alegre, Jonathan, Bassett, Katharine, Ilenia Papa, Vinuesa, C.G., Ohkura, Naganari, Claudio Doglioni, Carola G. Vinuesa, Cuenca, M., Cook, M.C., Canaday, David H, Bolton, H., Sweet, Rebecca, Cook, Matthew C., Sayin, Ismail, Holly Bolton, Sweet, Rebecca A, Roco, Jonathan A., Naganari Ohkura, Sakaguchi, S., Cañete, Pablo F., Ohkura, N., F Canete, Pablo, Gonzalez-Figueroa, Paula, Jonathan A. Roco, Lopez, A., Meyer-Hermann, Michael, Sakaguchi, Shimon, Prof, Doglioni, C., Roco, J.A., Vinuesa, Carola G, Bolton, Holly, Katharine J. Bassett, Cook, Matthew   +72 more
core   +1 more source

Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

Frontiers in Immunology, 2018
Follicular helper (TFH) and regulatory (TFR) cells are critical players in managing germinal center (GC) reactions that accomplish effective humoral immune responses.
Hristo Georgiev, Inga Ravens, Georgia Papadogianni, Stephan Halle, Bernard Malissen, Gabriela G. Loots, Reinhold Förster, Günter Bernhardt   +7 more
doaj   +1 more source

The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells

Frontiers in Immunology, 2018
BackgroundT follicular helper (Tfh) cells are key players in the production of antibody-producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are important where antibody formation is implicated in disease, such ...
Elizabeth F. Wallin, Danika L. Hill, Danika L. Hill, Michelle A. Linterman, Kathryn J. Wood   +4 more
doaj   +1 more source

Stat3 Is Important for Follicular Regulatory T Cell Differentiation

PLOS ONE, 2016
The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper (Tfr) cells. How Tfr cells develop and how their suppressive activity functions are not well understood.
Wu, Hao, Xie, Markus M., Liu, Hong, Dent, Alexander   +3 more
openaire   +4 more sources

CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes. [PDF]

Front Immunol, 2018
Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity ...
Benet ZL, Marthi M, Ke F, Wu R, Turner JS, Gabayre JB, Ivanitskiy MI, Sethi SS, Grigorova IL.   +8 more
europepmc   +2 more sources