Results 51 to 60 of about 253,632 (296)

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]

, 2016
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo, CARONNA, Roberto, CHIRLETTI, Piero, CIARDI, Antonio, DEL BENE, GABRIELLA, FARELLI, FRANCESCO, Focaccetti, Chiara, Longo, Flavia, MORELLI, Sergio, PACELLA, ILENIA, PICONESE, SILVIA, SACCO, LUCA, SCHINZARI, VALERIA, TIMPERI, ELEONORA, VESTRI, Anna Rita   +14 more
core   +1 more source

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine, 2020
Summary: Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies.
Seth D. Reighard, Stacey A. Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch, Jasmine A. Tuazon, Marat V. Khodoun, Leah C. Kottyan, David F. Smith, Hermine I. Brunner, Stephen N. Waggoner   +11 more
doaj   +1 more source

MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis [PDF]

, 2016
MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with ...
Alivernini, Stefano, Benvenuto, Roberta, Canestri, Silvia, Di Mario, Clara, Elmesmari, Aziza, Fedele, Anna Laura, Ferraccioli, Gianfranco, Gigante, Maria Rita, Gremese, Elisa, Kurowska-Stolarska, Mariola, Mangoni, Antonella, McInnes, Iain B., Petricca, Luca, Tolusso, Barbara   +13 more
core   +2 more sources

A T follicular helper cell origin for T regulatory type 1 cells

Cellular & Molecular Immunology, 2023
AbstractChronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+ T cells into T regulatory type 1 (TR1) cells, a subset of interleukin-10-producing Treg cells that do not express FOXP3. The identities of the progenitor(s) and transcriptional regulators of this T-cell subset remain unclear. Here, we show that the peptide-
Patricia Solé, Jun Yamanouchi, Josep Garnica, Muhammad Myn Uddin, Robert Clarke, Joel Moro, Nahir Garabatos, Shari Thiessen, Mireia Ortega, Santiswarup Singha, Debajyoti Mondal, César Fandos, Julio Saez-Rodriguez, Yang Yang, Pau Serra, Pere Santamaria   +15 more
openaire   +2 more sources

Prognostic information from nonmalignant and malignant lymphocytes in follicular lymphoma in relation to therapy [PDF]

, 2011
Follicular lymphoma is the most common indolent lymphoma. It is composed of centrocytes and centroblasts, residing in follicles that also harbour nonmalignant immune and stroma cells.
Wahlin, Björn Engelbrekt
core   +1 more source

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming [PDF]

, 2015
Foxp3(+) regulatory T cells (Tregs) maintain immune homoeostasis through mechanisms that remain incompletely defined. Here by two-photon (2P) imaging, we examine the cellular dynamics of endogenous Tregs.
Cahalan, Michael D, Deswarte, Kim, Dong, Tobias X, Greenberg, Milton L, Hammad, Hamida, Lambrecht, Bart, Matheu, Melanie, Othy, Shivashankar, Parker, Ian, Schuijs, Martijn   +9 more
core   +3 more sources

Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]

, 2016
Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E., Calandra, Ricardo Saul, Micevych, P. E., Paredes, A. H., Rudolph, L. M., Tesone, Marta, Wu, T. J.   +6 more
core   +1 more source

Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers

Nature Communications, 2023
Follicular helper T cells (TFH) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (TFR) prevent the emergence of self-reactive B cells and help to extinguish the reaction.
Julia Merkenschlager, Riza-Maria Berz, Victor Ramos, Maximilian Uhlig, Andrew J. MacLean, Carla R. Nowosad, Thiago Y. Oliveira, Michel C. Nussenzweig   +7 more
doaj   +1 more source

Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth. [PDF]

, 2015
Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma.
Agostinelli, C, Benvenuti, P, Casellato, A, Fuligni, F, Mandato, E, Piazza, Francesco, Pileri, Sa, Pizzi, Marco, Rugge, Massimo, Semenzato, Gianpietro Carlo   +9 more
core   +1 more source

Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

Frontiers in Immunology, 2018
An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to ...
Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou   +7 more
doaj   +1 more source