Results 71 to 80 of about 15,978,556 (170)

Follicular Regulatory T Cells and Follicular Helper T Cells: Role in HIV Pathogenesis [PDF]

, 2018
The role and function of human T follicular regulatory (TFR) cells in healthy individuals are not completely understood, partly due to its previous grouping with T follicular helper (TFH) cells and partly due to the difficulty in obtaining human ...
Salvatore, Bradley
core  

Increased circulating follicular regulatory T cells in Hashimoto’s thyroiditis

Autoimmunity, 2018
Objective: Follicular T helper (Tfh) cells are involved in the pathogenesis of Hashimoto's thyroiditis (HT), while follicular T regulatory (Tfr) cells inhibit Tfh cells, which mediate B cell responses. However, the role of Tfr cells in HT remains unclear.
Jiwei Zhao, Yanxia Chen, Zhenyao Xu, Wei Yang, Zhongliang Zhu, Yingxiang Song, Jinlin Liu   +6 more
doaj   +1 more source

IgG4-Related Disease (IgG4-RD) with Unique Combined Generalized Skin Rashes and Biliary Tract Manifestation: A Comprehensive Immunological Analysis

Dermatopathology
IgG4-RD is a multisystem fibroinflammatory disease characterized by the infiltration of tissues by IgG4 plasma cells. Combined skin and biliary tract involvement in IgG4-RD has not been described.
Ye La Jung, Sudhanshu Agrawal, Beverly Wang, Sudhir Gupta   +3 more
doaj   +1 more source

Control of Germinal Center Responses by T-Follicular Regulatory Cells

Frontiers in Immunology, 2018
Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential role in the control of immune homeostasis. In order to control diverse types of immune responses Treg cells must themselves show functional heterogeneity to ...
James B. Wing, Murat Tekgüç, Shimon Sakaguchi, Shimon Sakaguchi   +3 more
doaj   +1 more source

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers [PDF]

Blood, 2014
Key Points RTX treatment results in loss of human GC B cells. Human Tfh and Tfr cells do not require GC B cells for their maintenance.
Wallin, Elizabeth F, Jolly, Elaine C, Suchánek, Ondřej, Bradley, J Andrew, Espéli, Marion, Jayne, David RW, Linterman, Michelle A, Smith, Kenneth GC   +7 more
openaire   +4 more sources

T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker [PDF]

, 2010
Regulatory T-cells (Tregs), characterized as CD4+CD25(hi) T-cells expressing FOXP3, play a crucial role in controlling healthy immune development during early immune maturation. Recently, FOXP3 demethylation was suggested to be a novel marker for natural
Laura Layland, Liu, Jing, Jing Liu, Schaub, Bianca, Layland, Laura, Mutius, Erika von, Illi, Sabina, Lluis, Anna, Bianca Schaub, Erika von Mutius, Anna Lluis, Sabina Illi, Olek, Sven, Sven Olek, Liu, J;Lluis, A;Illi, S;Layland, L;Olek, S;von Mutius, E;Schaub, B   +14 more
core   +2 more sources

Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells. [PDF]

PLoS ONE, 2014
The biology of follicular lymphoma (FL) is largely dictated by the immune-effector and stromal cells that comprise its tumor microenvironment. FL-infiltrating T-cell populations that are thought to be fundamental to FL biology are follicular helper T ...
Michael T Brady, Shannon P Hilchey, Ollivier Hyrien, Stephen A Spence, Steven H Bernstein   +4 more
doaj   +1 more source

T Follicular Regulatory Cells and Antibody Responses in Transplantation

Transplantation, 2018
Abstract De novo donor-specific antibody (DSA) formation is a major problem in transplantation, and associated with long-term graft decline and loss as well as sensitization, limiting future transplant options. Forming high-affinity, long-lived antibody responses involves a process called the germinal center (GC) reaction, and requires ...
openaire   +3 more sources

Follicular T cells in the ovarian cancer immune microenvironment: biological insights and translational implications

Frontiers in Immunology
BackgroundOvarian cancer, particularly high-grade serous ovarian cancer (HGSOC), exhibits a generally poor response to immune checkpoint inhibitors, and its underlying mechanisms remain incompletely defined.
Yidan Xu, Li Li
doaj   +1 more source

Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5+CD8+ T Cells

Transplantation Direct
Background. Alloprimed antibody-suppressor CXCR5+CD8+ T cells (CD8+ TAb-supp cells) downregulate alloantibody production, mediate cytotoxicity of IgG+ B cells, and prolong allograft survival.
Jason M. Zimmerer, PhD, Sachi Chaudhari, BS, Kavya Koneru, BS, Jing L. Han, MD, PhD, Mahmoud Abdel-Rasoul, MA, Hope Uwase, MA, Tai Yi, MD, Christopher K. Breuer, MD, Ginny L. Bumgardner, MD, PhD   +8 more
doaj   +1 more source