Results 91 to 100 of about 15,978,556 (170)

The Balance in T Follicular Helper Cell Subsets Is Altered in Neuromyelitis Optica Spectrum Disorder Patients and Restored by Rituximab

Frontiers in Immunology, 2019
Neuromyelitis optica spectrum disorder (NMOSD) is a rare and severe auto-immune disease of the central nervous system driven by pathogenic antibodies mainly directed against aquaporin-4 (AQP4-Ab). Treatment of NMOSD currently relies on immunosuppressants
Philippe Nicolas, Philippe Nicolas, Anne Ruiz, Alvaro Cobo-Calvo, Alvaro Cobo-Calvo, Guillaume Fiard, Pascale Giraudon, Sandra Vukusic, Sandra Vukusic, Romain Marignier, Romain Marignier, Romain Marignier   +11 more
doaj   +1 more source

The B-Cell Follicle in HIV Infection: Barrier to a Cure

Frontiers in Immunology, 2018
The majority of HIV replication occurs in secondary lymphoid organs (SLOs) such as the spleen, lymph nodes, and gut-associated lymphoid tissue. Within SLOs, HIV RNA+ cells are concentrated in the B-cell follicle during chronic untreated infection, and ...
Matthew P. Bronnimann, Pamela J. Skinner, Elizabeth Connick   +2 more
doaj   +1 more source

Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells. [PDF]

Elife, 2023
Ke F, Benet ZL, Maz MP, Liu J, Dent AL, Kahlenberg JM, Grigorova IL.   +6 more
europepmc   +1 more source

PD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cells

Copyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).Humoral responses
Antunes, Diogo, Ribeiro, Filipa, Graca, Luis, Filipe, Beatriz, Jesus, Kátia, Correia, Ricardo, Fonseca, Válter R, Pires, Ana R., Kumar, Saumya, Rino, José   +9 more
core   +1 more source

Immunity to self co-generates regulatory T cells [PDF]

, 2008
Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to autoimmune disease.
Kent P. Jensen, Spiros Fourlanos, James A. Dromey, Stuart I. Mannering, Helen E. Young, Daniel J. Thearle, Bo Han Lee, Leonard C. Harrison, Larissa Belov   +8 more
core  

Regulation of the IgE response by T follicular regulatory cells

Allergology International
Allergen-specific IgE is a major mediator of allergic responses and contributes greatly to allergic disease in the human population. Therapies that inhibit the production of IgE would be useful for lessening the burden of allergic disease. A great deal of research has focused on how IgE responses are regulated, and several factors that promote the ...
openaire   +3 more sources

Deep immunophenotypic dissection and clinical impact of T cells in the follicular lymphoma microenvironment

Haematologica
Follicular lymphoma (FL) is an indolent B cell lymphoma with a heterogenous disease course, and patients may not require immediate treatment upon diagnosis.
Sary El Daker, David Qualls, Andriy Derkach, Samida Beqaj, Leonardo Boiocchi, Venkatraman Seshan, Jeeyeon Baik, Menglei Zhu, Gilles Salles, Ahmet Dogan, Mikhail Roshal, Pallavi Galera   +11 more
doaj   +1 more source

Association of follicular helper T and follicular regulatory T cells with severity and hyperglycemia in hospitalized COVID-19 patients. [PDF]

Virulence, 2022
Zahran AM, Abdel-Rahim MH, Nasif KA, Hussein S, Hafez R, Ahmad AB, Saad K, Elhoufey A, Hussein HAM, Thabet AA, El-Badawy O.   +10 more
europepmc   +1 more source

The Function of Themis2 in B Cells [PDF]

, 2015
Thymocyte-expressed molecule involved in selection 2 (Themis2) is the second member of the Themis family. Recently, the first member of the Themis family, Themis, has been reported to be part of the TCR signalling cascade and its deletion severely ...
Hartweger, H
core  

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

, 2016
Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process.
Hong Liu, Shan Lu, Chen, Yuxin, Wu, Hao, Xu, Lin-Lin, Paula Teuscher, Liu, Hong, Hao Wu, Lu, Shan, Yuxin Chen, Wang, Shixia, Teuscher, Paula, Alexander L. Dent, Lin‐Lin Xu, Shixia Wang, Dent, Alexander L.   +15 more
core   +1 more source