Results 81 to 90 of about 42,893 (255)

The epigenetic trajectory of type 1 regulatory T cells

eLife
The epigenome of T follicular helper cells prepares them for conversion into type 1 regulatory T cells.
David P Turicek, Xiaoxiao Wan
doaj   +1 more source

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

Nature Communications, 2017
IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.
Christoph Jandl, Sue M. Liu, Pablo F. Cañete, Joanna Warren, William E. Hughes, Alexis Vogelzang, Kylie Webster, Maria E. Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King   +14 more
doaj   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Regulation of T follicular helper cells by ICOS

Oncotarget, 2015
T follicular helper (TFH) cells are gatekeepers of the humoral immune response. Without help from this CD4+ T cell subset, B cells cannot differentiate into high-affinity memory B cells and antibody-producing long-lived plasma cells which are the basis of protective immune responses.
openaire   +2 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses

Cell Reports
Summary: Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in ...
Chenfei He, Shan Wang, Marion Moreews, Shengduo Pei, Guangchun Chen, Quan-Zhen Li, Alberto Del Monte Monge, Almudena R. Ramiro, Curtis Cai, Mauro Gaya, Patricia Barral, Marcus Buggert, Facundo D. Batista, Mikael C.I. Karlsson   +13 more
doaj   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

CD4+T Cells: Differentiation and Functions

Clinical and Developmental Immunology, 2012
CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the ...
Rishi Vishal Luckheeram, Rui Zhou, Asha Devi Verma, Bing Xia   +3 more
doaj   +1 more source