Results 91 to 100 of about 15,025,843 (286)

Th17 effector cells support B bell responses outside of germinal centres [PDF]

, 2012
Th17 cells are pro-inflammatory CD4+T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes.
David R Withers, Brewer James M., Benson, RA, David R. Withers, Paola Conigliaro, Agapitos Patakas (120270), Benson, R.A., Iain B McInnes, Patakas, A, David R. Withers (120281), Paul Garside, McInnes Iain B., Paul Garside (21184), Conigliaro, P, Withers, DR, Robert A. Benson, McInnes, I.B., CONIGLIARO, PAOLA, Patakas Agapitos, Benson Robert A., Patakas, A., Conigliaro, P., Withers David R., Agapitos Patakas, Brewer, J.M., Iain B. McInnes (120290), Robert A Benson, Paola Conigliaro (71046), Conigliaro Paola, Garside Paul, Robert A. Benson (120275), Garside, P, Mcinnes, LB, Garside, P., James M. Brewer, Iain B. McInnes, James M Brewer, Withers, D.R., Brewer, JM, James M. Brewer (120295)   +39 more
core   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Development and function of follicular helper T cells

Bioscience, Biotechnology, and Biochemistry, 2016
AbstractMost currently available vaccines rely on the induction of long-lasting protective humoral immune responses by memory B cells and plasma cells. Antibody responses against most antigens require interactions between antigen-specific B cells and CD4+ T cells. Follicular helper T cells (TFH cells) are specialized subset of T cells that provide help
openaire   +2 more sources

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine, 2020
Summary: Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies.
Seth D. Reighard, Stacey A. Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch, Jasmine A. Tuazon, Marat V. Khodoun, Leah C. Kottyan, David F. Smith, Hermine I. Brunner, Stephen N. Waggoner   +11 more
doaj   +1 more source

Follicular B helper T cells in antibody responses and autoimmunity

, 2015
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer.
Garcia De Vinuesa, Maria Carola, Mackay, Charles R, Moser, Bernhard, Tangye, Stuart G   +3 more
core   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Altered Phenotypes of Colonic and Peripheral Blood Follicular Helper and Follicular Cytotoxic T Cells in Mice with DSS-Induced Colitis

, 2023
Yan Long, Chang-Sheng Xia, Xingyue Zeng, Jinghong Feng, Yinting Ma, Chen Liu Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yan Long; Chen Liu, Department of Clinical Laboratory,
Feng J, Long Y, Ma Y, Zeng X, Liu C, Xia CS   +5 more
core  

Foxp3+ follicular regulatory T cells control the germinal center response [PDF]

, 2011
Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of TFH numbers maintains self tolerance.
Beaton, Laura, Fagarasan, Sidonia, Kallies, Axel, Smith, Kenneth G.C., Linterman, Michelle A., Divekar, Devina P., Kawamoto, Shimpei, Srivastava, Monika, Pierson, Wim, Lee, Sau K., Liston, Adrian, Hogan, Jennifer J., Rayner, Tim F., Vinuesa, Carola G.   +13 more
core   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source