Results 101 to 110 of about 67,870 (201)

Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion

Cell Reports
Summary: SARS-CoV-2-neutralizing antibody titers serve as immune correlates of protection against COVID-19; however, the durability varies among vaccinees.
Masanori Isogawa, Masahiro Shinoda, Ryutaro Kotaki, Kazutaka Terahara, Taishi Onodera, Kiyomi Kabasawa, Mio Toyama-Kousaka, Mizuki Fujisawa, Mitsukaze Watanabe, Keisuke Tonouchi, Tommy Terooatea, Ayumi Kitano, Yu Adachi, Saya Moriyama, Tomohiro Takano, Shuetsu Fukushi, Takayuki Matsumura, Kazuo Yamashita, Masaharu Shinkai, Yoshimasa Takahashi   +19 more
doaj   +1 more source

Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective

Heliyon
Helper T cells are traditionally classified into T helper 1 (TH1) and T helper 2 (TH2). The more recent discoveries of T helper 17 (TH17), follicular helper T cells (TFH) and regulatory T cells (Treg) enhanced our understanding on the mechanisms of ...
Andy Ka Chun Kan, Wang Tik Tang, Philip H. Li   +2 more
doaj   +1 more source

Recycling probability and dynamical properties of germinal center reactions

, 2001
We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the ...
Deutsch, Andreas, Meyer-Hermann, Michael, Or-Guil, Michal   +2 more
core   +2 more sources

Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. [PDF]

, 2019
The germinal center (GC) is the anatomical site where humoral immunity evolves. B cells undergo cycles of proliferation and selection to produce high-affinity Abs against Ag. Direct linkage of a TLR9 agonist (CpG) to a T-dependent Ag increases the number
Ansel, K Mark, DeFranco, Anthony L, Wigton, Eric J   +2 more
core   +1 more source

S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. [PDF]

, 2019
Germinal centres are important sites for antibody diversification and affinity maturation, and are also a common origin of B cell malignancies. Despite being made up of motile cells, germinal centres are tightly confined within B cell follicles. The cues
Cyster, Jason G, Lu, Erick, Muppidi, Jagan R, Wolfreys, Finn D, Xu, Ying   +4 more
core   +1 more source

Occurrence and role of Tph cells in various renal diseases

Molecular Medicine
A new population of peripheral helper T (Tph) cells has been identified and contributed to various autoimmune diseases. Tph cells can secrete interleukin-21 (IL-21), interferon (IFN) and C-X-C motif chemokine ligand 13 (CXCL13) to moderate renal disease.
Junyi Ren, Kuai Ma, Xiangheng Lu, Haoyu Peng, Jia Wang, Moussa Ide Nasser, Chi Liu   +6 more
doaj   +1 more source

A novel subset of T-helper cells: follicular T-helper cells and their markers

Haematologica, 2010
Camille Laurent, Nicolas Fazilleau, Pierre Brousset   +2 more
doaj   +1 more source

Follicular T helper cell populations

, 2016
Humoral immunity provides protection against subsequent infections. Antigen-specific, high-affinity, class-switched antibodies are produced by B cells through rounds of proliferation, B cell receptor rearrangement and selection in the germinal centres (GC).
openaire   +1 more source

Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection [PDF]

, 2019
Alexander S. Krupnick, Alice Y. Tong, Andrew E. Gelman, Ankit Bharat, Baddoura, Brian W. Wong, Chyi S. Hsieh, Daniel Kreisel, Francine L. Kelly, Hiemann, Hsi-Min Hsiao, Jason M. Gauthier, Jon H. Ritter, Li, Linh Vuong, Onyema, Ramsey R. Hachem, Ryuji Higashikubo, Satona Tanaka, Scott M. Palmer, Varun Puri, Vu Van, Wenjun Li, William M. Baldwin   +23 more
core   +2 more sources

IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells. [PDF]

NPJ Vaccines, 2023
Parvathaneni S, Yang J, Lotspeich-Cole L, Sakai J, Lee RC, Akkoyunlu M.   +5 more
europepmc   +1 more source