Results 101 to 110 of about 15,025,843 (286)

A Fine Romance: T Follicular Helper Cells and B Cells

, 2011
T follicular helper (Tfh) cells help B cells to generate affinity-matured antibodies. Three papers in this issue of Immunity (Choi et al., 2011; Kerfoot et al., 2011; Kitano et al., 2011) provide information about the reciprocal relationship between B ...
Cecile King, King, C ; https://orcid.org/   +1 more
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Activation of Peripheral T Follicular Helper Cells During Acute Dengue Virus Infection

, 2018
We investigated the immune response of peripheral T follicular helper cells during acute dengue virus infection in Thai children. We report significant associations between peripheral T follicular helper cell activation and plasmablast activation ...
Srikiatkhachorn, Anon, Alan L Rothman, Mathew, Anuja, Macareo, Louis, Green, Sharone, Siripen Kalayanarooj, Anon Srikiatkhachorn, Sangshin Park, Anuja Mathew, Kirk Haltaufderhyde, Haltaufderhyde, Kirk, Rothman, Alan L., Kalayanarooj, Siripen, Park, Sangshin, Louis Macareo, Sharone Green   +15 more
core   +1 more source

Follicular helper T cells: implications in neoplastic hematopathology.

, 2011
International audienceA distinct subset of T helper cells, named follicular T helper cells (T(FH), has been recently described. T(FH) cells are characterized by their homing capacities in the germinal centers of B-cell follicles where they interact with ...
Gaulard, Philippe, de Leval, Laurence
core   +5 more sources

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

Frontiers in Immunology, 2020
T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potential in
Diane G. Carnathan, Diane G. Carnathan, Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Ali H. Ellebedy, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Mohammed Ata Ur Rasheed, Matthias G. Pauthner, Matthias G. Pauthner, Gabriel Ozorowski, Gabriel Ozorowski, Rafi Ahmed, Rafi Ahmed, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Andrew B. Ward, Andrew B. Ward, Guido Silvestri, Guido Silvestri, Guido Silvestri, Shane Crotty, Shane Crotty, Shane Crotty, Michela Locci, Michela Locci, Michela Locci   +31 more
doaj   +1 more source

Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells [PDF]

, 2016
Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact.
Baz, Maysun S. Al, Feist, Randi K., Gurka, Stephanie, Hamelmann, Eckard, Hutloff, Andreas, Pietzke, Lea-Jean, Kroczek, Richard, Kroczek, Richard A., Van, Dana Vu, Beier, Katja C.   +9 more
core   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

, 2020
CD4+ T follicular helper cells (Tfh) are key drivers of antibody development. During Plasmodium falciparum malaria in children, the activation of Tfh is restricted to the Th1 subset and not associated with antibody levels.
Boyle, Michelle J, Andrew, Dean W, Chan, Jo-Anne, McCarthy, James S, Webb, Lachlan, Hogarth, P Mark, SheelaNair, Arya, Beeson, James G, Loughland, Jessica R, Dooley, Nicholas L, de Labastida Rivera, Fabian, Engwerda, Christian R, Amante, Fiona H, Wines, Bruce D, Dean W. Andrew, Michelle J. Boyle, P. Mark Hogarth, Jo-Anne Chan, Jessica R. Loughland, Nicholas L. Dooley, Fiona H. Amante, Christian R. Engwerda, Arya SheelaNair, James S. McCarthy, Bruce D. Wines, Lachlan Webb, James G. Beeson, Fabian de Labastida Rivera   +27 more
core   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source