Results 121 to 130 of about 15,025,843 (286)

Lineage specification and heterogeneity of T follicular helper cells

, 2009
T follicular helper (Tfh) cells were originally described as a non-polarized CD4(+) T cell subset with follicular homing capacity and a potent ability to induce antibody production from B cells.
Mackay, Charles R., Yu, Di, King, Cecile, Batten, Marcel, Cecile King, Charles R Mackay, Marcel Batten, Di Yu   +7 more
core   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Follicular lymphoma regulatory T-cell origin and function

Frontiers in Immunology
IntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment,
Stéphane Rodriguez, Mehdi Alizadeh, Claire Lamaison, Alexis Saintamand, Céline Monvoisin, Rachel Jean, Rachel Jean, Laurent Deleurme, Laurent Deleurme, Jose Ignacio Martin-Subero, Céline Pangault, Céline Pangault, Michel Cogné, Patricia Amé-Thomas, Patricia Amé-Thomas, Karin Tarte, Karin Tarte   +16 more
doaj   +1 more source

Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells. [PDF]

, 2014
The biology of follicular lymphoma (FL) is largely dictated by the immune-effector and stromal cells that comprise its tumor microenvironment. FL-infiltrating T-cell populations that are thought to be fundamental to FL biology are follicular helper T ...
Steven H. Bernstein, Michael T. Brady (565497), Shannon P. Hilchey, Stephen A. Spence, Steven H. Bernstein (256592), Stephen A. Spence (565499), Ollivier Hyrien, Michael T Brady, Steven H Bernstein, Ollivier Hyrien (565498), Michael T. Brady, Shannon P. Hilchey (256584), Shannon P Hilchey, Stephen A Spence, Brady Michael T., Hyrien Ollivier, Spence Stephen A., Hilchey Shannon P., Bernstein Steven H.   +18 more
core   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source

CD4+T Cells: Differentiation and Functions

Clinical and Developmental Immunology, 2012
CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the ...
Rishi Vishal Luckheeram, Rui Zhou, Asha Devi Verma, Bing Xia   +3 more
doaj   +1 more source

ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. [PDF]

, 2017
The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process ...
Ziv Shulman, Biram, Adi, Alexander D. Gitlin, Liat Stoler-Barak, Engelhardt, Britta, Roei D. Mazor, Stoler-Barak, Liat, Britta Engelhardt, Ofir Atrakchi, Gitlin, Alexander D, Atrakchi, Ofir, Adi Biram, Zaretsky, Irina, Feigelson, Sara W, Sara W. Feigelson, Mazor, Roei D, Shulman, Ziv, Irina Zaretsky, Zaretsky I, Biram A, Shulman Z, Stoler-Barak L, Gitlin AD, Atrakchi O, Feigelson SW, Engelhardt B, Mazor RD   +26 more
core   +2 more sources

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe   +10 more
wiley   +1 more source

CCR9 Expressing T Helper and T Follicular Helper Cells Exhibit Site-Specific Identities During Inflammatory Disease

Frontiers in Immunology, 2019
CD4+ T helper (Th) cells that express the gut homing chemokine receptor CCR9 are increased in the peripheral blood of patients with inflammatory bowel disease and Sjögren's syndrome and in the inflamed lesions of autoimmune diseases that affect the ...
Ilaria Cosorich, Helen M. McGuire, Joanna Warren, Mark Danta, Cecile King, Cecile King   +5 more
doaj   +1 more source

Follicular Regulatory T Cells and Follicular Helper T Cells: Role in HIV Pathogenesis [PDF]

, 2018
The role and function of human T follicular regulatory (TFR) cells in healthy individuals are not completely understood, partly due to its previous grouping with T follicular helper (TFH) cells and partly due to the difficulty in obtaining human ...
Salvatore, Bradley
core