Results 11 to 20 of about 42,893 (255)
Follicular Helper T Cells in DiGeorge Syndrome [PDF]
Frontiers in Immunology, 2018 DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune ...
Adam Klocperk +8 more
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T follicular helper cells in cancer
Trends in Cancer, 2023 T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated immune responses. Although the crucial function of these CD4+ T cells in infection and vaccination is well established, their involvement in cancer is only beginning to emerge.
Nicolás Gutiérrez-Melo +1 more
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T Follicular Helper Cells in Transplantation [PDF]
Transplantation, 2016 The recently described T follicular helper (Tfh) cell is required for the production of high affinity antibody. After contact with follicular dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by direct B cell-T cell interaction and production of IL-21.
Giles Desmond, Walters +1 more
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The dysfunction of T follicular helper cells [PDF]
Current Opinion in HIV and AIDS, 2014 T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody ...
Cubas R, Perreau M
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T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]
International Immunology, 2015 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
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Follicular Helper T Cells in Autoimmunity
Current Diabetes Reports, 2016 The development of multiple disease-relevant autoantibodies is a hallmark of autoimmune diseases. In autoimmune type 1 diabetes (T1D), a variable time frame of autoimmunity precedes the clinically overt disease. The relevance of T follicular helper (TFH) cells for the immune system is increasingly recognized.
Scherm, M.G., Ott, V., Daniel, C.
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The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. [PDF]
PLoS Pathogens, 2018 CD4 T cell-mediated help to CD8 T cells and B cells is a critical arm of the adaptive immune system required for control of pathogen infection. CD4 T cells express cytokines and co-stimulatory molecules that support a sustained CD8 T cell response and ...
Saravanan Raju +4 more
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T follicular helper cell diversity and plasticity [PDF]
Trends in Immunology, 2013 CD4(+) T helper (Th) cells play an instrumental role in orchestrating adaptive immune responses to invading pathogens through their ability to differentiate into specialized effector subsets. Part of this customized response requires the development of T follicular helper (Tfh) cells, which provide help to B cells for the generation of germinal centers
Jennifer L, Cannons +2 more
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FACS Staining for Follicular Helper T Cells
Bio-Protocol, 2012 Germinal center is the primary site for B cells to undergo somatic hypermutation and class switching. A recently discovered subset of T cells known as T follicular helper (TFH) cells are essential for germinal center reaction and thus have been the ...
Zheng Liu
doaj +1 more source