Results 31 to 40 of about 14,832,680 (288)
T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]
International Immunology, 2015 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
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Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]
Open Biology, 2013 Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes +2 more
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Early Growth Response genes 2 and 3 play a role in chronic inflammation pathology and are essential for the differentiation of T follicular helper cells [PDF]
, 2015 This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonThe Early Growth Response genes 2 and 3 (Egr2/3) are zinc finger transcription factors that play an important role in the immune system.
Ogbe, Ane Theodora
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Follicular Helper T Cells in Autoimmunity
Current Diabetes Reports, 2016 The development of multiple disease-relevant autoantibodies is a hallmark of autoimmune diseases. In autoimmune type 1 diabetes (T1D), a variable time frame of autoimmunity precedes the clinically overt disease. The relevance of T follicular helper (TFH) cells for the immune system is increasingly recognized.
Scherm, M.G., Ott, V., Daniel, C.
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The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target [PDF]
, 2012 Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial joints in which the development of autoantibodies represents a failure of normal tolerance mechanisms, suggesting a role for follicular helper T cells (TFH) in the ...
Chakera, Aron +16 more
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Haematologica, 2015 T follicular helper cells are the main CD4+ T cells specialized in supporting B-cell responses, but their role in driving transfusion-associated alloimmunization is not fully characterized.
Emmanuelle Godefroy +4 more
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Tumor Biology, 2017 Gastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular
Hong Zhang +12 more
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The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. [PDF]
PLoS Pathogens, 2018 CD4 T cell-mediated help to CD8 T cells and B cells is a critical arm of the adaptive immune system required for control of pathogen infection. CD4 T cells express cytokines and co-stimulatory molecules that support a sustained CD8 T cell response and ...
Saravanan Raju +4 more
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CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]
, 2013 Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen +35 more
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T follicular helper cell diversity and plasticity [PDF]
Trends in Immunology, 2013 CD4(+) T helper (Th) cells play an instrumental role in orchestrating adaptive immune responses to invading pathogens through their ability to differentiate into specialized effector subsets. Part of this customized response requires the development of T follicular helper (Tfh) cells, which provide help to B cells for the generation of germinal centers
Jennifer L, Cannons +2 more
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