Results 11 to 20 of about 14,832,680 (288)
Memory T follicular helper CD4 T cells [PDF]
Frontiers in Immunology, 2015 T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity.
J. Scott eHale, Rafi eAhmed
doaj +5 more sources
Annual Review of Immunology, 2016 Although T cell help for B cells was described several decades ago, it was the identification of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of their dependence on BCL6 that led to the recognition of Tfh cells as an independent helper subset and accelerated the pace of discovery. More than 20 transcription factors,
Michelle Linterman +2 more
exaly +7 more sources
T follicular helper cells and T follicular regulatory cells in autoimmune diseases
Frontiers in Immunology, 2023 T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi +4 more
doaj +3 more sources
Hemato, 2022 Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features.
Karthik A. Ganapathi +2 more
doaj +2 more sources
Follicular Helper T Cells in DiGeorge Syndrome [PDF]
Frontiers in Immunology, 2018 DiGeorge syndrome is an immunodeficiency characterized by thymic dysplasia resulting in T cell lymphopenia. Most patients suffer from increased susceptibility to infections and heightened prevalence of autoimmune disorders, such as autoimmune ...
Adam Klocperk +8 more
doaj +4 more sources
Blood Relatives of Follicular Helper T Cells [PDF]
Immunity, 2011 Expression of the chemokine receptor CXCR5 identifies B follicular helper T cells. In this issue of Immunity, Morita et al. (2011) describe a heterogeneous circulating CXCR5(+)CD4(+) B cell helper population overrepresented in juvenile dermatomyositis patients.
Garcia De Vinuesa, Maria Carola +1 more
core +5 more sources
T follicular helper and T follicular regulatory cells have different TCR specificity [PDF]
Nature Communications, 2017 T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras +9 more
doaj +2 more sources
The elusive identity of T follicular helper cells
Trends in Immunology, 2010 Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-lived antibody responses. Despite an improved understanding of the molecular program that drives Tfh cell formation, their definition remains elusive: neither follicular homing ability, Bcl-6 expression nor IL-21 secretion are exclusive properties of T cells that help B
Yu, Di, Vinuesa, Carola G.
core +7 more sources
Elevated Proportions of Circulating CXCR5+ Follicular Helper T Cells Reflect the Presence of Airway Obstruction in Asthma [PDF]
Journal of Immunology ResearchRationale. The progressive decline in lung function observed in asthma is attributed to persistent type 2 airway inflammation and associated airway remodeling. While various immune cells are involved in localized type 2 airway inflammation, whether these
Tsukie Kin Tsukuda +6 more
doaj +2 more sources
T Follicular Helper Cells in Autoimmune Disorders [PDF]
Frontiers in Immunology, 2018 T follicular helper (Tfh) cells are a distinct subset of CD4+ T lymphocytes, specialized in B cell help and in regulation of antibody responses. They are required for the generation of germinal center reactions, where selection of high affinity antibody ...
Noémie Gensous +8 more
doaj +3 more sources