Results 11 to 20 of about 42,818 (256)
Frontiers in Immunology, 2023 T follicular helper cells comprise a specialized, heterogeneous subset of immune-competent T helper cells capable of influencing B cell responses in lymphoid tissues.
Julien Subburayalu +2 more
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T Follicular Helper Cells in Transplantation [PDF]
Transplantation, 2016 The recently described T follicular helper (Tfh) cell is required for the production of high affinity antibody. After contact with follicular dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by direct B cell-T cell interaction and production of IL-21.
Giles Desmond, Walters +1 more
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Hemato, 2022 Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features.
Karthik A. Ganapathi +2 more
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The dysfunction of T follicular helper cells [PDF]
Current Opinion in HIV and AIDS, 2014 T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody ...
Cubas R, Perreau M
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TFH cells in systemic sclerosis
Journal of Translational Medicine, 2021 Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and immune dysregulation evidenced by the infiltration of inflammatory cells in affected tissues and the ...
Pauline Beurier +8 more
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T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]
International Immunology, 2015 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
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Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]
Open Biology, 2013 Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes +2 more
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Follicular Helper T Cells in Autoimmunity
Current Diabetes Reports, 2016 The development of multiple disease-relevant autoantibodies is a hallmark of autoimmune diseases. In autoimmune type 1 diabetes (T1D), a variable time frame of autoimmunity precedes the clinically overt disease. The relevance of T follicular helper (TFH) cells for the immune system is increasingly recognized.
Scherm, M.G., Ott, V., Daniel, C.
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Haematologica, 2015 T follicular helper cells are the main CD4+ T cells specialized in supporting B-cell responses, but their role in driving transfusion-associated alloimmunization is not fully characterized.
Emmanuelle Godefroy +4 more
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Tumor Biology, 2017 Gastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular
Hong Zhang +12 more
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