Results 21 to 30 of about 13,929,929 (284)

T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]

International Immunology, 2015
Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
openaire   +2 more sources

Follicular Helper T Cells in Autoimmunity

Current Diabetes Reports, 2016
The development of multiple disease-relevant autoantibodies is a hallmark of autoimmune diseases. In autoimmune type 1 diabetes (T1D), a variable time frame of autoimmunity precedes the clinically overt disease. The relevance of T follicular helper (TFH) cells for the immune system is increasingly recognized.
Scherm, M.G., Ott, V., Daniel, C.
openaire   +4 more sources

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target [PDF]

, 2012
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial joints in which the development of autoantibodies represents a failure of normal tolerance mechanisms, suggesting a role for follicular helper T cells (TFH) in the ...
Chakera, Aron, Bowness, Paul, Raashid A. Luqmani, Morteau, O, Luqmani, Raashid, Bennett, S., Richard J. Cornall, Bowness, P., Luqmani, Raashid A, Bennett, Sophia C, Morteau, O., Aron Chakera, Sophia C. Bennett, Paul Bowness, Morteau, Olivier, Cornall, Richard J, Bennett, SC, Olivier Morteau, Cornall, R., Cornall, Richard, Chakera, A, Luqmani, R.   +21 more
core   +1 more source

TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization

Haematologica, 2015
T follicular helper cells are the main CD4+ T cells specialized in supporting B-cell responses, but their role in driving transfusion-associated alloimmunization is not fully characterized.
Emmanuelle Godefroy, Hui Zhong, Petra Pham, David Friedman, Karina Yazdanbakhsh   +4 more
doaj   +1 more source

Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer

Tumor Biology, 2017
Gastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular
Hong Zhang, Rongxi Yue, Pengfei Zhao, Xuetao Yu, Junguo Li, Guoqing Ma, Jiahong Tang, Lixin Zhang, Liying Feng, Lidong Sun, Zongchang Song, Chunliang Guo, Ning Wang   +12 more
doaj   +1 more source

T follicular helper cell diversity and plasticity [PDF]

Trends in Immunology, 2013
CD4(+) T helper (Th) cells play an instrumental role in orchestrating adaptive immune responses to invading pathogens through their ability to differentiate into specialized effector subsets. Part of this customized response requires the development of T follicular helper (Tfh) cells, which provide help to B cells for the generation of germinal centers
Jennifer L, Cannons, Kristina T, Lu, Pamela L, Schwartzberg   +2 more
openaire   +2 more sources

The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. [PDF]

PLoS Pathogens, 2018
CD4 T cell-mediated help to CD8 T cells and B cells is a critical arm of the adaptive immune system required for control of pathogen infection. CD4 T cells express cytokines and co-stimulatory molecules that support a sustained CD8 T cell response and ...
Saravanan Raju, Kohei Kometani, Tomohiro Kurosaki, Andrey S Shaw, Takeshi Egawa   +4 more
doaj   +1 more source

FACS Staining for Follicular Helper T Cells

Bio-Protocol, 2012
Germinal center is the primary site for B cells to undergo somatic hypermutation and class switching. A recently discovered subset of T cells known as T follicular helper (TFH) cells are essential for germinal center reaction and thus have been the ...
Zheng Liu
doaj   +1 more source

Regulation of IgE by T follicular helper cells

Journal of Leukocyte Biology, 2020
Abstract Allergies to food and environmental antigens have steeply grown to epidemic proportions. IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis. There is now compelling evidence that one of the hallmarks of anaphylaxis-inducing IgE molecules is their high affinity for allergen, and the ...
Uthaman Gowthaman, Jennifer S. Chen, Stephanie C. Eisenbarth   +2 more
openaire   +3 more sources

The function and origin of the CD4+ T cell in the classical Hodgkin lymphoma microenvironment [PDF]

, 2012
PhDClassical Hodgkin lymphoma (CHL) is a germinal centre B cell malignancy where the bulk of the tumour comprises a non-clonal immune infiltrate enriched for CD4+ T cells.
Greaves, Paul
core   +4 more sources