Results 21 to 30 of about 42,818 (256)
The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. [PDF]
PLoS Pathogens, 2018 CD4 T cell-mediated help to CD8 T cells and B cells is a critical arm of the adaptive immune system required for control of pathogen infection. CD4 T cells express cytokines and co-stimulatory molecules that support a sustained CD8 T cell response and ...
Saravanan Raju +4 more
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T follicular helper cell diversity and plasticity [PDF]
Trends in Immunology, 2013 CD4(+) T helper (Th) cells play an instrumental role in orchestrating adaptive immune responses to invading pathogens through their ability to differentiate into specialized effector subsets. Part of this customized response requires the development of T follicular helper (Tfh) cells, which provide help to B cells for the generation of germinal centers
Jennifer L, Cannons +2 more
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FACS Staining for Follicular Helper T Cells
Bio-Protocol, 2012 Germinal center is the primary site for B cells to undergo somatic hypermutation and class switching. A recently discovered subset of T cells known as T follicular helper (TFH) cells are essential for germinal center reaction and thus have been the ...
Zheng Liu
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Immunological mechanism of IgG4-related disease
Journal of Translational Autoimmunity, 2020 IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory disorder in multiple organs, characterized by abundant infiltration of IgG4-positive plasmacytes and fibrosis in the involved organs.
Changyan Liu, Panpan Zhang, Wen Zhang
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Regulation of IgE by T follicular helper cells
Journal of Leukocyte Biology, 2020 Abstract Allergies to food and environmental antigens have steeply grown to epidemic proportions. IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis. There is now compelling evidence that one of the hallmarks of anaphylaxis-inducing IgE molecules is their high affinity for allergen, and the ...
Uthaman Gowthaman +2 more
openaire +3 more sources
Cells, 2023 Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV ...
Bradley Salvatore +8 more
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Advances in the role of follicular T helper cells in graft versus host diseases
Liver Research, 2017 Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases.
Maogen Chen +4 more
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Follicular helper T cell in immunity and autoimmunity [PDF]
Brazilian Journal of Medical and Biological Research, 2016 The traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh).
Mesquita Jr, D. +6 more
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Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center
Cell Reports, 2017 Summary: Follicular T helper (TFH) cells orchestrate the germinal center (GC) response locally. TFH localization in GCs is controlled by chemo-guidance cues and antigen-specific adhesion. Here.
Hu Yan +13 more
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T follicular helper and T follicular regulatory cells have different TCR specificity
Nature Communications, 2017 T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras +9 more
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