Results 31 to 40 of about 1,927,651 (292)
Regulatory T Cells in GVHD Therapy
Frontiers in Immunology, 2021 Graft versus host disease (GVHD) is a common complication and the leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Wen-wen Guo +5 more
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Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection [PDF]
, 2013 Conventional and regulatory T cells develop in the thymus where they are exposed to samples of self-peptide MHC (pMHC) ligands. This probabilistic process selects for cells within a range of responsiveness that allows the detection of foreign antigen ...
Bains, Iren +3 more
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Regulatory T-cell therapy approaches
Clinical and Experimental Immunology, 2022 SummaryRegulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex vivo expanded autologous Tregs continues to progress through mid- to late-phase clinical trials in several disease spaces and has generated promising preliminary safety and ...
McCallion, O +3 more
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In vitro Regulatory T cells Differentiation From Naïve T Cells
Bio-Protocol, 2014 In the past years, a subset of regulatory T cells (Tregs) expressing CD4, CD25 and the transcription factor FoxP3 has gained considerable attention as key regulators of T-cell tolerance and homeostasis (Sakaguchi, 2004).
Tomas Dalotto +2 more
doaj +1 more source
Memory regulatory T cells in pregnancy
Frontiers in Immunology, 2023 Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos. In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to result in the rejection of embryos while damaging the invading placenta ...
Zeyang Chen +5 more
doaj +1 more source
Role of dendritic cells in the induction of regulatory T cells [PDF]
, 2011 Dendritic cells (DCs) play a key role in initiating immune responses and maintaining immune tolerance. In addition to playing a role in thymic selection, DCs play an active role in tolerance under steady state conditions through several mechanisms which ...
Rahul Kushwah, Jim Hu
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Regulatory T cells in retroviral infections. [PDF]
PLoS Pathogens, 2018 Tight regulation of immune responses is not only critical for preventing autoimmune diseases but also for preventing immunopathological damage during infections in which overactive immune responses may be more harmful for the host than the pathogen ...
Kim J Hasenkrug +2 more
doaj +1 more source
Selective inhibition of T suppressor-cell function by a monosaccharide [PDF]
, 1981 Interactions between regulatory T lymphocytes and other cells are assumed to occur at the level of the cell surface. T cells which suppress the generation of specifically effector cells have been described as having antigenic, idiotypic, allotypic and I ...
AA Moscona +22 more
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Regulatory T cells in paracoccidioidomycosis
Virulence, 2019 This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen.
Vera L. G. Calich +2 more
doaj +1 more source
Current Opinion in Immunology, 2001 There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
openaire +3 more sources