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Characteristics of Regulatory T cells
Journal of Medical Science, 2016 Regulatory T cells (Tregs) is heterogenic subpopulation of T cells that is able to suppress function of effector cells during the immune response. Among them are natural (nTreg) and induced Treg (Tr1, Th3, CD4+CD25-).
Magdalena Frydrychowicz +6 more
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Clinical & Translational Immunology, 2020 Objectives Regulatory T cells (Tregs) are a vital sub‐population of CD4+ T cells with major roles in immune tolerance and homeostasis. Given such properties, the use of regulatory T cells for immunotherapies has been extensively investigated, with a ...
Juewan Kim +8 more
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Immunometabolism of regulatory T cells [PDF]
Nature Immunology, 2016 The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commensal-microbiota-derived metabolites ...
Ryan, Newton +2 more
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In vitro Regulatory T cells Differentiation From Naïve T Cells
Bio-Protocol, 2014 In the past years, a subset of regulatory T cells (Tregs) expressing CD4, CD25 and the transcription factor FoxP3 has gained considerable attention as key regulators of T-cell tolerance and homeostasis (Sakaguchi, 2004).
Tomas Dalotto +2 more
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Regulatory T Cells in Autoimmune Vasculitis
Frontiers in Immunology, 2022 Blood vessels are indispensable for host survival and are protected from inappropriate inflammation by immune privilege. This protection is lost in patients with autoimmune vasculitides, a heterogeneous group of diseases causing damage to arteries ...
Ke Jin +8 more
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MicroRNA 10a marks regulatory T cells. [PDF]
PLoS ONE, 2012 MicroRNAs (miRNAs) are crucial for regulatory T cell (Treg) stability and function. We report that microRNA-10a (miR-10a) is expressed in Tregs but not in other T cells including individual thymocyte subsets.
Lukas T Jeker +7 more
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Memory regulatory T cells in pregnancy
Frontiers in Immunology, 2023 Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos. In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to result in the rejection of embryos while damaging the invading placenta ...
Zeyang Chen +5 more
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Regulatory T Cells in Autoimmmunity [PDF]
Annual Review of Immunology, 2000 Clonal deletion of autoreactive T cells in the thymus is not the sole mechanism for the induction of tolerance to self-antigens since partial depletion of peripheral CD4+T cells from neonatal and adult animals results in the development of organ-specific autoimmunity.
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Regulatory T Cells in AKI [PDF]
Journal of the American Society of Nephrology, 2013 Human AKI is manifested by inflammation, and an early feature in the pathogenesis is the accumulation of immune cells in the kidney. To understand the pathophysiology of AKI, results from animal models have shown a causal relation between the leukocyte activation and infiltration to the kidney after kidney ischemia-reperfusion.
Gilbert R, Kinsey +2 more
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Current Opinion in Immunology, 2001 There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
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