Results 41 to 50 of about 14,721,754 (256)

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

Cell Reports, 2018
Summary: Psoriasis is a chronic relapsing, remitting interleukin (IL)-23/IL-17-driven skin disease mediated by the interplay of T cells and polymorphonuclear granulocytes. Although preclinical studies have provided insights into the mechanisms of disease
Tom Hartwig, Pascale Zwicky, Bettina Schreiner, Nikhil Yawalkar, Phil Cheng, Alexander Navarini, Reinhard Dummer, Lukas Flatz, Curdin Conrad, Christoph Schlapbach, Burkhard Becher   +10 more
doaj   +1 more source

In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]

, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, de Waal-Malefyt, R., Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre   +39 more
core   +1 more source

REGULATORY T–CELLS: ORIGIN AND FUNCTION

Медицинская иммунология, 2014
. Over the past decade a population of so–called “regulatory T cells” (Treg cells) has been linked to the prevention of autoimmunity. In this review we discuss the molecular mechanisms of Treg cells development and function including the identification ...
I. S. Freidlin
doaj   +1 more source

CD25(+) Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection [PDF]

, 2010
Regulatory CD4(+) T cells have been shown to be important in limiting immune responses, but their role in respiratory viral infections has received little attention.
Harker, JA, Johansson, C, Cecilia Johansson, Tregoning, John S, Jürgen Schwarze, Atabani, Sowsan F, Lee, Debbie C P, Atabani, SF, Lee, DC, Harker, James A E, Peter J. M. Openshaw, Schwarze, J, Harker, JAE, James A. E. Harker, Openshaw, Peter J M, Tregoning, JS, Lee, DCP, Johansson, Cecilia, John S. Tregoning, Openshaw, PJ, Schwarze, Jürgen, Openshaw, PJM, Debbie C. P. Lee, Sowsan F. Atabani   +23 more
core   +1 more source

Persistent immune activation in CVID and the role of IVIg in its suppression

Frontiers in Immunology, 2014
Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as ...
Dominic ePaquin-Proulx, Johan K. Sandberg   +1 more
doaj   +1 more source

Regulatory T Cells in Atherogenesis

Journal of Atherosclerosis and Thrombosis, 2012
Atherosclerosis is believed to be an inflammatory condition of the arterial wall. It has become apparent that various types of cells of innate and adaptive immunity participate in atherogenesis. T cells are of particular interest because they mediate pathogenic immune responses involved in the acceleration of atherosclerosis.
Sasaki, Naoto, Yamashita, Tomoya, Takeda, Masafumi, Hirata, Ken-ichi   +3 more
openaire   +3 more sources

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

Plasticity of human CD4 T cell subsets

Frontiers in Immunology, 2014
Human beings are exposed to a variety of different pathogens, which induce tailored immune responses and consequently generate highly diverse populations of pathogen-specific T cells.
Jens eGeginat, Moira eParoni, Stefano eMaglie, Johanna Sophie Alfen, Ilko eKastirr, Paola eGruarin, Marco eDeSimone, Massimiliano ePagani, Sergio eAbrignani   +8 more
doaj   +1 more source

Immunometabolism of regulatory T cells [PDF]

Nature Immunology, 2016
The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commensal-microbiota-derived metabolites ...
Ryan, Newton, Bhavana, Priyadharshini, Laurence A, Turka   +2 more
openaire   +2 more sources

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source